| Summary: | Compound 3-amino-1-(4-chlorophenyl)-9-methoxy-1<i>H</i>-benzo[<i>f</i>]chromene-2-carbonitrile (<b>4</b>), was synthesized via the reaction of 7-methoxynaphthalen-2-ol (<b>1</b>), 4-chlorobenzaldehyde (<b>2</b>), and malononitrile (<b>3</b>) in an ethanolic piperidine solution under microwave irradiation. The synthesized pyran derivative <b>4</b> was asserted through spectral data and X-ray diffraction. The molecular structure of compound <b>4</b> was established unambiguously through the single crystal X-ray measurements and crystallized in the Triclinic, P-1, a = 8.7171 (4) Å, b = 10.9509 (5) Å, c = 19.5853 (9) Å, <i>α</i> = 78.249 (2)°, <i>β</i> = 89.000 (2)°, <i>γ</i> = 70.054 (2)°, V = 1717.88 (14) Å<sup>3</sup>, Z = 4. The target molecule has been screened for antibacterial and antifungal functionality. Compound <b>4</b> exhibited favorable antimicrobial activities that resembled the reference antimicrobial agents with an IZ range of 16–26 mm. In addition, MIC, MBC, and MFC were assessed and screened for molecule <b>4</b>, revealing bactericidal and fungicidal effects. Lastly, a molecular docking analysis was addressed and conducted for this desired molecule.
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