Ran GTPase: A Key Player in Tumor Progression and Metastasis
Ran (Ras-related nuclear protein) GTPase is a member of the Ras superfamily. Like all the GTPases, Ran cycles between an active (GTP-bound) and inactive (GDP-bound) state. However, Ran lacks the CAAX motif at its C-terminus, a feature of other small GTPases that ensures a plasma membrane localizatio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.00345/full |
| _version_ | 1830284045417709568 |
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| author | Zied Boudhraa Zied Boudhraa Euridice Carmona Euridice Carmona Diane Provencher Diane Provencher Diane Provencher Anne-Marie Mes-Masson Anne-Marie Mes-Masson Anne-Marie Mes-Masson |
| author_facet | Zied Boudhraa Zied Boudhraa Euridice Carmona Euridice Carmona Diane Provencher Diane Provencher Diane Provencher Anne-Marie Mes-Masson Anne-Marie Mes-Masson Anne-Marie Mes-Masson |
| author_sort | Zied Boudhraa |
| collection | DOAJ |
| description | Ran (Ras-related nuclear protein) GTPase is a member of the Ras superfamily. Like all the GTPases, Ran cycles between an active (GTP-bound) and inactive (GDP-bound) state. However, Ran lacks the CAAX motif at its C-terminus, a feature of other small GTPases that ensures a plasma membrane localization, and largely traffics between the nucleus and the cytoplasm. Ran regulates nucleo-cytoplasmic transport of molecules through the nuclear pore complex and controls cell cycle progression through the regulation of microtubule polymerization and mitotic spindle formation. The disruption of Ran expression has been linked to cancer at different levels – from cancer initiation to metastasis. In the present review, we discuss the contribution of Ran in the acquisition of three hallmarks of cancer, namely, proliferative signaling, resistance to apoptosis, and invasion/metastasis, and highlight its prognostic value in cancer patients. In addition, we discuss the use of this GTPase as a therapeutic target in cancer. |
| first_indexed | 2024-12-19T03:12:26Z |
| format | Article |
| id | doaj.art-9ed14a39ad3648e085253a9da3884efd |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-19T03:12:26Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-9ed14a39ad3648e085253a9da3884efd2022-12-21T20:37:59ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-05-01810.3389/fcell.2020.00345526872Ran GTPase: A Key Player in Tumor Progression and MetastasisZied Boudhraa0Zied Boudhraa1Euridice Carmona2Euridice Carmona3Diane Provencher4Diane Provencher5Diane Provencher6Anne-Marie Mes-Masson7Anne-Marie Mes-Masson8Anne-Marie Mes-Masson9Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC, CanadaInstitut du Cancer de Montréal (ICM), Montreal, QC, CanadaCentre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC, CanadaInstitut du Cancer de Montréal (ICM), Montreal, QC, CanadaCentre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC, CanadaInstitut du Cancer de Montréal (ICM), Montreal, QC, CanadaDivision of Gynecologic Oncology, Université de Montréal, Montreal, QC, CanadaCentre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC, CanadaInstitut du Cancer de Montréal (ICM), Montreal, QC, CanadaDepartment of Medicine, Université de Montréal, Montreal, QC, CanadaRan (Ras-related nuclear protein) GTPase is a member of the Ras superfamily. Like all the GTPases, Ran cycles between an active (GTP-bound) and inactive (GDP-bound) state. However, Ran lacks the CAAX motif at its C-terminus, a feature of other small GTPases that ensures a plasma membrane localization, and largely traffics between the nucleus and the cytoplasm. Ran regulates nucleo-cytoplasmic transport of molecules through the nuclear pore complex and controls cell cycle progression through the regulation of microtubule polymerization and mitotic spindle formation. The disruption of Ran expression has been linked to cancer at different levels – from cancer initiation to metastasis. In the present review, we discuss the contribution of Ran in the acquisition of three hallmarks of cancer, namely, proliferative signaling, resistance to apoptosis, and invasion/metastasis, and highlight its prognostic value in cancer patients. In addition, we discuss the use of this GTPase as a therapeutic target in cancer.https://www.frontiersin.org/article/10.3389/fcell.2020.00345/fullRan GTPasecancermetastasissurvivalproliferation |
| spellingShingle | Zied Boudhraa Zied Boudhraa Euridice Carmona Euridice Carmona Diane Provencher Diane Provencher Diane Provencher Anne-Marie Mes-Masson Anne-Marie Mes-Masson Anne-Marie Mes-Masson Ran GTPase: A Key Player in Tumor Progression and Metastasis Frontiers in Cell and Developmental Biology Ran GTPase cancer metastasis survival proliferation |
| title | Ran GTPase: A Key Player in Tumor Progression and Metastasis |
| title_full | Ran GTPase: A Key Player in Tumor Progression and Metastasis |
| title_fullStr | Ran GTPase: A Key Player in Tumor Progression and Metastasis |
| title_full_unstemmed | Ran GTPase: A Key Player in Tumor Progression and Metastasis |
| title_short | Ran GTPase: A Key Player in Tumor Progression and Metastasis |
| title_sort | ran gtpase a key player in tumor progression and metastasis |
| topic | Ran GTPase cancer metastasis survival proliferation |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.00345/full |
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