JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies

JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies

JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the myriad of cellular processes initiated by various types of ligands such as growth factors, hormones, and cytokines. The physiological processes regulated by JAK/STAT signaling are immune regulation, cell prolife...

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Bibliographic Details
Main Authors: Bilal Rah, Rafiq A Rather, Gh Rasool Bhat, Abdul Basit Baba, Ifra Mushtaq, Muzamil Farooq, Tahira Yousuf, Sadaf B Dar, Sabra Parveen, Rukhsana Hassan, Fozia Mohammad, Iqbal Qassim, Abida Bhat, Shazia Ali, Mahrukh Hamid Zargar, Dil Afroze
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
solid tumors
signaling
molecular targets
therapeutic opportunities
inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.821344/full

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