SP1 transcriptionally activates HTR2B to aggravate traumatic spinal cord injury by shifting microglial M1/M2 polarization

SP1 transcriptionally activates HTR2B to aggravate traumatic spinal cord injury by shifting microglial M1/M2 polarization

Abstract Background Spinal cord injury (SCI) can result in structural and functional damage to the spinal cord, which may lead to loss of limb movement and sensation, loss of bowel and bladder control, and other complications. Previous studies have revealed the critical influence of trans-acting tra...

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Bibliographic Details
Main Authors: Qifei Xu, Fanguo Kong, Guanghui Zhao, Junwei Jin, Shengkai Feng, Ming Li
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Spinal cord injury
SP1
HTR2B
Microglia
Macrophage polarization
Online Access:https://doi.org/10.1186/s13018-024-04678-z

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