| Summary: | Seven new unusual polysulfated steroids—topsentiasterol sulfate G (<b>1</b>), topsentiasterol sulfate I (<b>2</b>), topsentiasterol sulfate H (<b>3</b>), bromotopsentiasterol sulfate D (<b>4</b>), dichlorotopsentiasterol sulfate D (<b>8</b>), bromochlorotopsentiasterol sulfate D (<b>9</b>), and 4<i>β</i>-hydroxyhalistanol sulfate C (<b>10</b>), as well as three previously described—topsentiasterol sulfate D (<b>7</b>), chlorotopsentiasterol sulfate D (<b>5</b>) and iodotopsentiasterol sulfate D (<b>6</b>) have been isolated from the marine sponge <i>Halichondria vansoesti</i>. Structures of these compounds were determined by detailed analysis of 1D- and 2D-NMR and HRESIMS data, as well as chemical transformations. The effects of the compounds on human prostate cancer cells PC-3 and 22Rv1 were investigated.
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