Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes
For the past several decades, the prevalence of obesity and type 2 diabetes (T2D) has continued to rise on a global level. The risk contributing to this pandemic implicates both genetic and environmental factors, which are functionally integrated by epigenetic mechanisms. While these conditions are...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/7/982 |
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| author | Federica Zatterale Gregory Alexander Raciti Immacolata Prevenzano Alessia Leone Michele Campitelli Veronica De Rosa Francesco Beguinot Luca Parrillo |
| author_facet | Federica Zatterale Gregory Alexander Raciti Immacolata Prevenzano Alessia Leone Michele Campitelli Veronica De Rosa Francesco Beguinot Luca Parrillo |
| author_sort | Federica Zatterale |
| collection | DOAJ |
| description | For the past several decades, the prevalence of obesity and type 2 diabetes (T2D) has continued to rise on a global level. The risk contributing to this pandemic implicates both genetic and environmental factors, which are functionally integrated by epigenetic mechanisms. While these conditions are accompanied by major abnormalities in fuel metabolism, evidence indicates that altered immune cell functions also play an important role in shaping of obesity and T2D phenotypes. Interestingly, these events have been shown to be determined by epigenetic mechanisms. Consistently, recent epigenome-wide association studies have demonstrated that immune cells from obese and T2D individuals feature specific epigenetic profiles when compared to those from healthy subjects. In this work, we have reviewed recent literature reporting epigenetic changes affecting the immune cell phenotype and function in obesity and T2D. We will further discuss therapeutic strategies targeting epigenetic marks for treating obesity and T2D-associated inflammation. |
| first_indexed | 2024-03-09T10:22:27Z |
| format | Article |
| id | doaj.art-9edcf110c91d47cc98ebc910c78e8b3b |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T10:22:27Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-9edcf110c91d47cc98ebc910c78e8b3b2023-12-01T21:56:40ZengMDPI AGBiomolecules2218-273X2022-07-0112798210.3390/biom12070982Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 DiabetesFederica Zatterale0Gregory Alexander Raciti1Immacolata Prevenzano2Alessia Leone3Michele Campitelli4Veronica De Rosa5Francesco Beguinot6Luca Parrillo7Department of Translational Medical Science, Federico II University of Naples, 80131 Naples, ItalyDepartment of Translational Medical Science, Federico II University of Naples, 80131 Naples, ItalyDepartment of Translational Medical Science, Federico II University of Naples, 80131 Naples, ItalyDepartment of Translational Medical Science, Federico II University of Naples, 80131 Naples, ItalyDepartment of Translational Medical Science, Federico II University of Naples, 80131 Naples, ItalyURT Genomic of Diabetes, Institute of Experimental Endocrinology and Oncology, National Research Council, 80131 Naples, ItalyDepartment of Translational Medical Science, Federico II University of Naples, 80131 Naples, ItalyDepartment of Translational Medical Science, Federico II University of Naples, 80131 Naples, ItalyFor the past several decades, the prevalence of obesity and type 2 diabetes (T2D) has continued to rise on a global level. The risk contributing to this pandemic implicates both genetic and environmental factors, which are functionally integrated by epigenetic mechanisms. While these conditions are accompanied by major abnormalities in fuel metabolism, evidence indicates that altered immune cell functions also play an important role in shaping of obesity and T2D phenotypes. Interestingly, these events have been shown to be determined by epigenetic mechanisms. Consistently, recent epigenome-wide association studies have demonstrated that immune cells from obese and T2D individuals feature specific epigenetic profiles when compared to those from healthy subjects. In this work, we have reviewed recent literature reporting epigenetic changes affecting the immune cell phenotype and function in obesity and T2D. We will further discuss therapeutic strategies targeting epigenetic marks for treating obesity and T2D-associated inflammation.https://www.mdpi.com/2218-273X/12/7/982epigeneticsimmune systemobesity and type 2 diabetesinflammationadipocyte hypertrophyWBCs |
| spellingShingle | Federica Zatterale Gregory Alexander Raciti Immacolata Prevenzano Alessia Leone Michele Campitelli Veronica De Rosa Francesco Beguinot Luca Parrillo Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes Biomolecules epigenetics immune system obesity and type 2 diabetes inflammation adipocyte hypertrophy WBCs |
| title | Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes |
| title_full | Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes |
| title_fullStr | Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes |
| title_full_unstemmed | Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes |
| title_short | Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes |
| title_sort | epigenetic reprogramming of the inflammatory response in obesity and type 2 diabetes |
| topic | epigenetics immune system obesity and type 2 diabetes inflammation adipocyte hypertrophy WBCs |
| url | https://www.mdpi.com/2218-273X/12/7/982 |
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