Randomized Trial of Acute Changes in Plasma Phosphate After Phosphorus-Standardized Meals in Peritoneal Dialysis
Introduction: Hyperphosphatemia is associated with increased morbidity and mortality in patients with chronic kidney disease. The aim of this study was to assess whether a meal with high phosphorus content would affect plasma phosphate in the hours that follow among subjects with end-stage kidney di...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-02-01
|
| Series: | Kidney International Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468024920317149 |
| _version_ | 1818589373813227520 |
|---|---|
| author | Martin Thorbjørn Lundin Iain Bressendorff Bent Kristensen Niklas Rye Jørgensen Rizwan Butt Ditte Hansen |
| author_facet | Martin Thorbjørn Lundin Iain Bressendorff Bent Kristensen Niklas Rye Jørgensen Rizwan Butt Ditte Hansen |
| author_sort | Martin Thorbjørn Lundin |
| collection | DOAJ |
| description | Introduction: Hyperphosphatemia is associated with increased morbidity and mortality in patients with chronic kidney disease. The aim of this study was to assess whether a meal with high phosphorus content would affect plasma phosphate in the hours that follow among subjects with end-stage kidney disease on peritoneal dialysis. Methods: This was a single-blinded randomized cross-over trial of 12 subjects on maintenance peritoneal dialysis, in which subjects were randomized to consume a meal with either high or low phosphorus content on 2 separate trial days. On each trial day, plasma phosphate was measured immediately before consumption of the standardized meal and after 1, 2, 3, and 5 hours. Results: The mean fasting plasma phosphate at baseline was 1.69 ± 0.22 mmol/l. Plasma phosphate was similar between the 2 meals at baseline, as well as at 1, 2, 3, and 5 hours after consumption. The largest observed difference in plasma phosphate between the 2 meals was 0.15 mmol/l, which occurred 5 hours after consumption (high-phosphorus meal 1.75 ± 0.32 mmol/l vs. low-phosphorus meal 1.60 ± 0.14 mmol/l (P = 0.06)). Using summary analyses for repeated measures, we observed a significant difference in the plasma phosphate between the 2 meals (P = 0.03). Conclusion: Our results show that in subjects with end-stage kidney disease, a meal with high phosphorus content has only a negligible effect on plasma phosphate compared to a meal with low phosphorus content. Thus, large increases in plasma phosphate cannot be accounted for by a high intake of phosphorus in the hours before blood sampling. |
| first_indexed | 2024-12-16T09:39:37Z |
| format | Article |
| id | doaj.art-9edd429f12f4438bb55e9d0ce1bdca82 |
| institution | Directory Open Access Journal |
| issn | 2468-0249 |
| language | English |
| last_indexed | 2024-12-16T09:39:37Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney International Reports |
| spelling | doaj.art-9edd429f12f4438bb55e9d0ce1bdca822022-12-21T22:36:18ZengElsevierKidney International Reports2468-02492021-02-0162304312Randomized Trial of Acute Changes in Plasma Phosphate After Phosphorus-Standardized Meals in Peritoneal DialysisMartin Thorbjørn Lundin0Iain Bressendorff1Bent Kristensen2Niklas Rye Jørgensen3Rizwan Butt4Ditte Hansen5Department of Nephrology, Herlev and Gentofte Hospital, Herlev, Denmark; Correspondence: Martin Thorbjørn Lundin, Department of Nephrology, Herlev and Gentofte Hospital, Borgmester Ib Juuls Vej 1, DK-2730 Herlev, Denmark.Department of Nephrology, Herlev and Gentofte Hospital, Herlev, DenmarkDepartment of Nuclear Medicine, Herlev and Gentofte Hospital, Herlev, DenmarkDepartment of Clinical Biochemistry, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Nephrology, Herlev and Gentofte Hospital, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Nephrology, Herlev and Gentofte Hospital, Herlev, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkIntroduction: Hyperphosphatemia is associated with increased morbidity and mortality in patients with chronic kidney disease. The aim of this study was to assess whether a meal with high phosphorus content would affect plasma phosphate in the hours that follow among subjects with end-stage kidney disease on peritoneal dialysis. Methods: This was a single-blinded randomized cross-over trial of 12 subjects on maintenance peritoneal dialysis, in which subjects were randomized to consume a meal with either high or low phosphorus content on 2 separate trial days. On each trial day, plasma phosphate was measured immediately before consumption of the standardized meal and after 1, 2, 3, and 5 hours. Results: The mean fasting plasma phosphate at baseline was 1.69 ± 0.22 mmol/l. Plasma phosphate was similar between the 2 meals at baseline, as well as at 1, 2, 3, and 5 hours after consumption. The largest observed difference in plasma phosphate between the 2 meals was 0.15 mmol/l, which occurred 5 hours after consumption (high-phosphorus meal 1.75 ± 0.32 mmol/l vs. low-phosphorus meal 1.60 ± 0.14 mmol/l (P = 0.06)). Using summary analyses for repeated measures, we observed a significant difference in the plasma phosphate between the 2 meals (P = 0.03). Conclusion: Our results show that in subjects with end-stage kidney disease, a meal with high phosphorus content has only a negligible effect on plasma phosphate compared to a meal with low phosphorus content. Thus, large increases in plasma phosphate cannot be accounted for by a high intake of phosphorus in the hours before blood sampling.http://www.sciencedirect.com/science/article/pii/S2468024920317149end-stage kidney diseasemineral metabolismnutritionperitoneal dialysisphosphatephosphorus |
| spellingShingle | Martin Thorbjørn Lundin Iain Bressendorff Bent Kristensen Niklas Rye Jørgensen Rizwan Butt Ditte Hansen Randomized Trial of Acute Changes in Plasma Phosphate After Phosphorus-Standardized Meals in Peritoneal Dialysis Kidney International Reports end-stage kidney disease mineral metabolism nutrition peritoneal dialysis phosphate phosphorus |
| title | Randomized Trial of Acute Changes in Plasma Phosphate After Phosphorus-Standardized Meals in Peritoneal Dialysis |
| title_full | Randomized Trial of Acute Changes in Plasma Phosphate After Phosphorus-Standardized Meals in Peritoneal Dialysis |
| title_fullStr | Randomized Trial of Acute Changes in Plasma Phosphate After Phosphorus-Standardized Meals in Peritoneal Dialysis |
| title_full_unstemmed | Randomized Trial of Acute Changes in Plasma Phosphate After Phosphorus-Standardized Meals in Peritoneal Dialysis |
| title_short | Randomized Trial of Acute Changes in Plasma Phosphate After Phosphorus-Standardized Meals in Peritoneal Dialysis |
| title_sort | randomized trial of acute changes in plasma phosphate after phosphorus standardized meals in peritoneal dialysis |
| topic | end-stage kidney disease mineral metabolism nutrition peritoneal dialysis phosphate phosphorus |
| url | http://www.sciencedirect.com/science/article/pii/S2468024920317149 |
| work_keys_str_mv | AT martinthorbjørnlundin randomizedtrialofacutechangesinplasmaphosphateafterphosphorusstandardizedmealsinperitonealdialysis AT iainbressendorff randomizedtrialofacutechangesinplasmaphosphateafterphosphorusstandardizedmealsinperitonealdialysis AT bentkristensen randomizedtrialofacutechangesinplasmaphosphateafterphosphorusstandardizedmealsinperitonealdialysis AT niklasryejørgensen randomizedtrialofacutechangesinplasmaphosphateafterphosphorusstandardizedmealsinperitonealdialysis AT rizwanbutt randomizedtrialofacutechangesinplasmaphosphateafterphosphorusstandardizedmealsinperitonealdialysis AT dittehansen randomizedtrialofacutechangesinplasmaphosphateafterphosphorusstandardizedmealsinperitonealdialysis |