Development and Verification of a Hypoxic Gene Signature for Predicting Prognosis, Immune Microenvironment, and Chemosensitivity for Osteosarcoma

Development and Verification of a Hypoxic Gene Signature for Predicting Prognosis, Immune Microenvironment, and Chemosensitivity for Osteosarcoma

Objective: Hypoxic tumors contribute to local failure and distant metastases. Nevertheless, the molecular hallmarks of hypoxia remain ill-defined in osteosarcoma. Here, we developed a hypoxic gene signature in osteosarcoma prognoses.Methods: With the random survival forest algorithm, a prognostic hy...

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Bibliographic Details
Main Authors: Fengfeng Wu, Juntao Xu, Mingchao Jin, Xuesheng Jiang, Jianyou Li, Xiongfeng Li, Zhuo Chen, Jiangbo Nie, Zhipeng Meng, Guorong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
osteosarcoma
prognosis
hypoxia
gene signature
immune microenvironment
nomogram
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.705148/full

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