Sclerosing angiomatoid nodular transformation of the spleen in a child with anemia: a case report and review of the literature
Abstract Background Sclerosing angiomatoid nodular transformation of the spleen is a relatively rare benign vascular lesion in both adult and pediatric age groups with unclear etiopathogenesis and variable clinical presentations. Many benign and also malignant splenic masses could mimic sclerosing a...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-023-04144-0 |
| _version_ | 1797452528162439168 |
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| author | Neda Soleimani Bita Geramizadeh Mohammad Hossein Anbardar Ali Bahador Dornaz Safavi Sahand Mohammadzadeh S. Saeed Kasaee Abbas Ayoub |
| author_facet | Neda Soleimani Bita Geramizadeh Mohammad Hossein Anbardar Ali Bahador Dornaz Safavi Sahand Mohammadzadeh S. Saeed Kasaee Abbas Ayoub |
| author_sort | Neda Soleimani |
| collection | DOAJ |
| description | Abstract Background Sclerosing angiomatoid nodular transformation of the spleen is a relatively rare benign vascular lesion in both adult and pediatric age groups with unclear etiopathogenesis and variable clinical presentations. Many benign and also malignant splenic masses could mimic sclerosing angiomatoid nodular transformation, both clinically and radiologically. Herein, we report our experience with a case of sclerosing angiomatoid nodular transformation in a 3-year-old girl. Case report A 3-year-old Iranian girl presented with abdominal pain, back pain, and constipation for 2 weeks. She was being followed up by a pediatrician due to her short stature and persistent anemia. Physical examination showed stable vital signs, short stature, pallor, and a puffy face. Laboratory evaluation showed normochromic normocytic anemia with a normal reticulocyte count, ferritin, and hemoglobin electrophoresis. Radiologic assessments revealed a hypoechoic lesion in the spleen with high vascularity, clinically suspected to be lymphoma. She was operated on, and after partial splenectomy, pathologic evaluation of the spleen showed a solitary, well-demarcated, and unencapsulated dark mass. Microscopic examination revealed micronodular appearance composed of irregular-shaped vascular spaces lined by plump endothelial cells and surrounded by concentric collagen fibers, features in keeping with sclerosing angiomatoid nodular transformation. The patient’s anemia was resolved after surgery, and no clinical or radiologic deficits were noted during the 10-month follow-up visits. Conclusion Although sclerosing angiomatoid nodular transformation is exceedingly rare in children, it should be considered a differential diagnosis in pediatric splenic neoplasms with concurrent hematologic manifestations, such as anemia. |
| first_indexed | 2024-03-09T15:10:00Z |
| format | Article |
| id | doaj.art-9ee152442bef414fb663355db514b94a |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-03-09T15:10:00Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-9ee152442bef414fb663355db514b94a2023-11-26T13:26:18ZengBMCJournal of Medical Case Reports1752-19472023-09-011711610.1186/s13256-023-04144-0Sclerosing angiomatoid nodular transformation of the spleen in a child with anemia: a case report and review of the literatureNeda Soleimani0Bita Geramizadeh1Mohammad Hossein Anbardar2Ali Bahador3Dornaz Safavi4Sahand Mohammadzadeh5S. Saeed Kasaee6Abbas Ayoub7Department of Pathology, Shiraz Medical School, Shiraz University of Medical SciencesDepartment of Pathology, Shiraz Medical School, Shiraz University of Medical SciencesDepartment of Pathology, Shiraz Medical School, Shiraz University of Medical SciencesShiraz Transplant Center, Abu Ali Sina Hospital, Shiraz University of Medical SciencesDepartment of Pathology, Shiraz Medical School, Shiraz University of Medical SciencesDepartment of Pathology, Shiraz Medical School, Shiraz University of Medical SciencesDepartment of Oncology and Hematology, Abu Ali Sina Hospital, Shiraz Transplant Center, Shiraz University of Medical SciencesShiraz Transplant Center, Abu Ali Sina HospitalAbstract Background Sclerosing angiomatoid nodular transformation of the spleen is a relatively rare benign vascular lesion in both adult and pediatric age groups with unclear etiopathogenesis and variable clinical presentations. Many benign and also malignant splenic masses could mimic sclerosing angiomatoid nodular transformation, both clinically and radiologically. Herein, we report our experience with a case of sclerosing angiomatoid nodular transformation in a 3-year-old girl. Case report A 3-year-old Iranian girl presented with abdominal pain, back pain, and constipation for 2 weeks. She was being followed up by a pediatrician due to her short stature and persistent anemia. Physical examination showed stable vital signs, short stature, pallor, and a puffy face. Laboratory evaluation showed normochromic normocytic anemia with a normal reticulocyte count, ferritin, and hemoglobin electrophoresis. Radiologic assessments revealed a hypoechoic lesion in the spleen with high vascularity, clinically suspected to be lymphoma. She was operated on, and after partial splenectomy, pathologic evaluation of the spleen showed a solitary, well-demarcated, and unencapsulated dark mass. Microscopic examination revealed micronodular appearance composed of irregular-shaped vascular spaces lined by plump endothelial cells and surrounded by concentric collagen fibers, features in keeping with sclerosing angiomatoid nodular transformation. The patient’s anemia was resolved after surgery, and no clinical or radiologic deficits were noted during the 10-month follow-up visits. Conclusion Although sclerosing angiomatoid nodular transformation is exceedingly rare in children, it should be considered a differential diagnosis in pediatric splenic neoplasms with concurrent hematologic manifestations, such as anemia.https://doi.org/10.1186/s13256-023-04144-0ChildSclerosing angiomatoid nodular transformationSpleenVascular neoplasm |
| spellingShingle | Neda Soleimani Bita Geramizadeh Mohammad Hossein Anbardar Ali Bahador Dornaz Safavi Sahand Mohammadzadeh S. Saeed Kasaee Abbas Ayoub Sclerosing angiomatoid nodular transformation of the spleen in a child with anemia: a case report and review of the literature Journal of Medical Case Reports Child Sclerosing angiomatoid nodular transformation Spleen Vascular neoplasm |
| title | Sclerosing angiomatoid nodular transformation of the spleen in a child with anemia: a case report and review of the literature |
| title_full | Sclerosing angiomatoid nodular transformation of the spleen in a child with anemia: a case report and review of the literature |
| title_fullStr | Sclerosing angiomatoid nodular transformation of the spleen in a child with anemia: a case report and review of the literature |
| title_full_unstemmed | Sclerosing angiomatoid nodular transformation of the spleen in a child with anemia: a case report and review of the literature |
| title_short | Sclerosing angiomatoid nodular transformation of the spleen in a child with anemia: a case report and review of the literature |
| title_sort | sclerosing angiomatoid nodular transformation of the spleen in a child with anemia a case report and review of the literature |
| topic | Child Sclerosing angiomatoid nodular transformation Spleen Vascular neoplasm |
| url | https://doi.org/10.1186/s13256-023-04144-0 |
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