Isolation of a Melanoblast Stimulator from <i>Dimocarpus longan</i>, Its Structural Modification, and Structure–Activity Relationships for Vitiligo
A novel melanoblast stimulator (<b>1</b>) was isolated from <i>Dimocarpus longan</i>. Its analogs were also synthesized to support a new furan-based melanoblast stimulator scaffold for treating vitiligo. Isolated 5-(hydroxymethyl)furfural (HMF, <b>1</b>) is a well...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/7/2135 |
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| author | Jae-Won Song Sunju Choi Gayeong Kim Hyang Bok Lee P. Sankara Rao Jeonghyun Shin Eun Ki Kim Dong-Gyu Cho |
| author_facet | Jae-Won Song Sunju Choi Gayeong Kim Hyang Bok Lee P. Sankara Rao Jeonghyun Shin Eun Ki Kim Dong-Gyu Cho |
| author_sort | Jae-Won Song |
| collection | DOAJ |
| description | A novel melanoblast stimulator (<b>1</b>) was isolated from <i>Dimocarpus longan</i>. Its analogs were also synthesized to support a new furan-based melanoblast stimulator scaffold for treating vitiligo. Isolated 5-(hydroxymethyl)furfural (HMF, <b>1</b>) is a well-known compound in the food industry. Surprisingly, the melanogenic activity of HMF (<b>1</b>) was discovered here for the first time. Both HMF and its synthetic analog (<b>16</b>) promote the differentiation and migration of melanoblasts in vitro. Typically, stimulator (<b>1</b>) upregulated MMP2 expression, which promoted the migration of melanoblasts in vitro. |
| first_indexed | 2024-03-09T11:37:20Z |
| format | Article |
| id | doaj.art-9ee17b5984474b37b34ba22b7197dd6b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T11:37:20Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9ee17b5984474b37b34ba22b7197dd6b2023-11-30T23:40:02ZengMDPI AGMolecules1420-30492022-03-01277213510.3390/molecules27072135Isolation of a Melanoblast Stimulator from <i>Dimocarpus longan</i>, Its Structural Modification, and Structure–Activity Relationships for VitiligoJae-Won Song0Sunju Choi1Gayeong Kim2Hyang Bok Lee3P. Sankara Rao4Jeonghyun Shin5Eun Ki Kim6Dong-Gyu Cho7Department of Chemistry and Chemical Engineering, Inha University, Incheon 22212, KoreaDepartment of Biological Engineering, Inha University, Incheon 22212, KoreaDepartment of Biological Engineering, Inha University, Incheon 22212, KoreaDepartment of Biological Engineering, Inha University, Incheon 22212, KoreaDepartment of Chemistry and Chemical Engineering, Inha University, Incheon 22212, KoreaDepartment of Dermatology, School of Medicine, Inha University, Incheon 22212, KoreaDepartment of Biological Engineering, Inha University, Incheon 22212, KoreaDepartment of Chemistry and Chemical Engineering, Inha University, Incheon 22212, KoreaA novel melanoblast stimulator (<b>1</b>) was isolated from <i>Dimocarpus longan</i>. Its analogs were also synthesized to support a new furan-based melanoblast stimulator scaffold for treating vitiligo. Isolated 5-(hydroxymethyl)furfural (HMF, <b>1</b>) is a well-known compound in the food industry. Surprisingly, the melanogenic activity of HMF (<b>1</b>) was discovered here for the first time. Both HMF and its synthetic analog (<b>16</b>) promote the differentiation and migration of melanoblasts in vitro. Typically, stimulator (<b>1</b>) upregulated MMP2 expression, which promoted the migration of melanoblasts in vitro.https://www.mdpi.com/1420-3049/27/7/2135melanoblaststimulatormelanogenesisvitiligo structure–activity relationships |
| spellingShingle | Jae-Won Song Sunju Choi Gayeong Kim Hyang Bok Lee P. Sankara Rao Jeonghyun Shin Eun Ki Kim Dong-Gyu Cho Isolation of a Melanoblast Stimulator from <i>Dimocarpus longan</i>, Its Structural Modification, and Structure–Activity Relationships for Vitiligo Molecules melanoblast stimulator melanogenesis vitiligo structure–activity relationships |
| title | Isolation of a Melanoblast Stimulator from <i>Dimocarpus longan</i>, Its Structural Modification, and Structure–Activity Relationships for Vitiligo |
| title_full | Isolation of a Melanoblast Stimulator from <i>Dimocarpus longan</i>, Its Structural Modification, and Structure–Activity Relationships for Vitiligo |
| title_fullStr | Isolation of a Melanoblast Stimulator from <i>Dimocarpus longan</i>, Its Structural Modification, and Structure–Activity Relationships for Vitiligo |
| title_full_unstemmed | Isolation of a Melanoblast Stimulator from <i>Dimocarpus longan</i>, Its Structural Modification, and Structure–Activity Relationships for Vitiligo |
| title_short | Isolation of a Melanoblast Stimulator from <i>Dimocarpus longan</i>, Its Structural Modification, and Structure–Activity Relationships for Vitiligo |
| title_sort | isolation of a melanoblast stimulator from i dimocarpus longan i its structural modification and structure activity relationships for vitiligo |
| topic | melanoblast stimulator melanogenesis vitiligo structure–activity relationships |
| url | https://www.mdpi.com/1420-3049/27/7/2135 |
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