Scarless wound healing programmed by core-shell microneedles
Abstract Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Herein, a core-shell structured microneedle array patch with programmed f...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-39129-6 |
| _version_ | 1797806591864471552 |
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| author | Ying Zhang Shenqiang Wang Yinxian Yang Sheng Zhao Jiahuan You Junxia Wang Jingwei Cai Hao Wang Jie Wang Wei Zhang Jicheng Yu Chunmao Han Yuqi Zhang Zhen Gu |
| author_facet | Ying Zhang Shenqiang Wang Yinxian Yang Sheng Zhao Jiahuan You Junxia Wang Jingwei Cai Hao Wang Jie Wang Wei Zhang Jicheng Yu Chunmao Han Yuqi Zhang Zhen Gu |
| author_sort | Ying Zhang |
| collection | DOAJ |
| description | Abstract Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Herein, a core-shell structured microneedle array patch with programmed functions (PF-MNs) is designed to dynamically modulate the wound immune microenvironment according to the varied healing phases. Specifically, PF-MNs combat multidrug-resistant bacterial biofilm at the early stage via generating reactive oxygen species (ROS) under laser irradiation. Subsequently, the ROS-sensitive MN shell gradually degrades to expose the MN core component, which neutralizes various inflammatory factors and promotes the phase transition from inflammation to proliferation. In addition, the released verteporfin inhibits scar formation by blocking Engrailed-1 (En1) activation in fibroblasts. Our experiments demonstrate that PF-MNs promote scarless wound repair in mouse models of both acute and chronic wounds, and inhibit the formation of hypertrophic scar in rabbit ear models. |
| first_indexed | 2024-03-13T06:09:35Z |
| format | Article |
| id | doaj.art-9ee1c1ca4aad4b04a1fa02fc50b0b70a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-13T06:09:35Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9ee1c1ca4aad4b04a1fa02fc50b0b70a2023-06-11T11:20:07ZengNature PortfolioNature Communications2041-17232023-06-0114111310.1038/s41467-023-39129-6Scarless wound healing programmed by core-shell microneedlesYing Zhang0Shenqiang Wang1Yinxian Yang2Sheng Zhao3Jiahuan You4Junxia Wang5Jingwei Cai6Hao Wang7Jie Wang8Wei Zhang9Jicheng Yu10Chunmao Han11Yuqi Zhang12Zhen Gu13Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang UniversityKey Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang UniversityKey Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang UniversityKey Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang UniversityKey Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang UniversityKey Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang UniversityDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang UniversityKey Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang UniversityDepartment of Burns and Wound Care Center, the Second Affiliated Hospital, College of Medicine, Zhejiang UniversityDepartment of Burns and Wound Care Center, the Second Affiliated Hospital, College of Medicine, Zhejiang UniversityKey Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang UniversityDepartment of Burns and Wound Care Center, the Second Affiliated Hospital, College of Medicine, Zhejiang UniversityKey Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang UniversityKey Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang UniversityAbstract Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Herein, a core-shell structured microneedle array patch with programmed functions (PF-MNs) is designed to dynamically modulate the wound immune microenvironment according to the varied healing phases. Specifically, PF-MNs combat multidrug-resistant bacterial biofilm at the early stage via generating reactive oxygen species (ROS) under laser irradiation. Subsequently, the ROS-sensitive MN shell gradually degrades to expose the MN core component, which neutralizes various inflammatory factors and promotes the phase transition from inflammation to proliferation. In addition, the released verteporfin inhibits scar formation by blocking Engrailed-1 (En1) activation in fibroblasts. Our experiments demonstrate that PF-MNs promote scarless wound repair in mouse models of both acute and chronic wounds, and inhibit the formation of hypertrophic scar in rabbit ear models.https://doi.org/10.1038/s41467-023-39129-6 |
| spellingShingle | Ying Zhang Shenqiang Wang Yinxian Yang Sheng Zhao Jiahuan You Junxia Wang Jingwei Cai Hao Wang Jie Wang Wei Zhang Jicheng Yu Chunmao Han Yuqi Zhang Zhen Gu Scarless wound healing programmed by core-shell microneedles Nature Communications |
| title | Scarless wound healing programmed by core-shell microneedles |
| title_full | Scarless wound healing programmed by core-shell microneedles |
| title_fullStr | Scarless wound healing programmed by core-shell microneedles |
| title_full_unstemmed | Scarless wound healing programmed by core-shell microneedles |
| title_short | Scarless wound healing programmed by core-shell microneedles |
| title_sort | scarless wound healing programmed by core shell microneedles |
| url | https://doi.org/10.1038/s41467-023-39129-6 |
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