Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in ChinaCapsule Summary
Background: Racial variation exists in the incidence of orofacial granulomatosis (OFG). The epidemiology and clinical characteristics of OFG in Asian countries are poorly described. Objective: To describe the epidemiologic and clinical features of OFG in China from data collected on chronic odontoge...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | JAAD International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266632872030033X |
| _version_ | 1818673077757673472 |
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| author | Minghui Wei, MM Cheng Xie, MD, PhD Yubo Liu, MM Yuhong Wang, MM Yuanyuan Wang, MM Xinwen Wang, MD, PhD Yuan Liu, MD, PhD |
| author_facet | Minghui Wei, MM Cheng Xie, MD, PhD Yubo Liu, MM Yuhong Wang, MM Yuanyuan Wang, MM Xinwen Wang, MD, PhD Yuan Liu, MD, PhD |
| author_sort | Minghui Wei, MM |
| collection | DOAJ |
| description | Background: Racial variation exists in the incidence of orofacial granulomatosis (OFG). The epidemiology and clinical characteristics of OFG in Asian countries are poorly described. Objective: To describe the epidemiologic and clinical features of OFG in China from data collected on chronic odontogenic infection and studied in actual practice regarding the long-term outcome of OFG patients receiving different treatments. Methods: Data on demographics, medical history, chronic odontogenic infection, and the extent of disease were collected, and long-term outcomes after the end of treatments were evaluated. Results: Of the 165 OFG patients, 118 (71.5%; 95% CI 64.6%-78.5%) had a chronic odontogenic infection. There was a variety of difference between OFG with and without chronic odontogenic infection. Approximately 98.3% (95% confidence interval 94.8%-100%) of OFG patients with chronic odontogenic infection who received dental treatment showed a marked response, of whom 31 patients (53.4%; 95% confidence interval 40.2%-66.7%) had complete remission. Limitations: Endoscopic investigations were not performed for most of the patients, and more detailed data were not collected, which might have demonstrated additional systemic problems. Conclusions: OFG with chronic odontogenic infection is the major clinical pattern of OFG in China, which may be a subtype of OFG. Dental treatment should necessarily be the preferred first-line therapy for such patients. |
| first_indexed | 2024-12-17T07:50:04Z |
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| id | doaj.art-9ee2dd5b10ea4ddfb672bdc2c2e52bb2 |
| institution | Directory Open Access Journal |
| issn | 2666-3287 |
| language | English |
| last_indexed | 2024-12-17T07:50:04Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JAAD International |
| spelling | doaj.art-9ee2dd5b10ea4ddfb672bdc2c2e52bb22022-12-21T21:57:53ZengElsevierJAAD International2666-32872020-12-0112126134Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in ChinaCapsule SummaryMinghui Wei, MM0Cheng Xie, MD, PhD1Yubo Liu, MM2Yuhong Wang, MM3Yuanyuan Wang, MM4Xinwen Wang, MD, PhD5Yuan Liu, MD, PhD6Department of Oral Medicine, School of Stomatology, the Fourth Military Medical University, Xi'an, China; Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Disease of China, State Key Laboratory of Military StomatologyShaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Disease of China, State Key Laboratory of Military Stomatology; Outpatient Department, School of Stomatology, the Fourth Military Medical University, Xi'an, ChinaDepartment of Stomatology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, ChinaDepartment of Oral Medicine, School of Stomatology, the Fourth Military Medical University, Xi'an, China; Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Disease of China, State Key Laboratory of Military StomatologyDepartment of Oral Medicine, School of Stomatology, the Fourth Military Medical University, Xi'an, China; Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Disease of China, State Key Laboratory of Military StomatologyDepartment of Oral Medicine, School of Stomatology, the Fourth Military Medical University, Xi'an, China; Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Disease of China, State Key Laboratory of Military Stomatology; Correspondence to: Xinwen Wang, MD, PhD, or Yuan Liu, MD, PhD, Changle W Rd 145, Xi'an, 710032, Shaanxi Province, China.Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Disease of China, State Key Laboratory of Military Stomatology; Department of Pathology, School of Stomatology, the Fourth Military Medical University, Xi'an, China; Correspondence to: Xinwen Wang, MD, PhD, or Yuan Liu, MD, PhD, Changle W Rd 145, Xi'an, 710032, Shaanxi Province, China.Background: Racial variation exists in the incidence of orofacial granulomatosis (OFG). The epidemiology and clinical characteristics of OFG in Asian countries are poorly described. Objective: To describe the epidemiologic and clinical features of OFG in China from data collected on chronic odontogenic infection and studied in actual practice regarding the long-term outcome of OFG patients receiving different treatments. Methods: Data on demographics, medical history, chronic odontogenic infection, and the extent of disease were collected, and long-term outcomes after the end of treatments were evaluated. Results: Of the 165 OFG patients, 118 (71.5%; 95% CI 64.6%-78.5%) had a chronic odontogenic infection. There was a variety of difference between OFG with and without chronic odontogenic infection. Approximately 98.3% (95% confidence interval 94.8%-100%) of OFG patients with chronic odontogenic infection who received dental treatment showed a marked response, of whom 31 patients (53.4%; 95% confidence interval 40.2%-66.7%) had complete remission. Limitations: Endoscopic investigations were not performed for most of the patients, and more detailed data were not collected, which might have demonstrated additional systemic problems. Conclusions: OFG with chronic odontogenic infection is the major clinical pattern of OFG in China, which may be a subtype of OFG. Dental treatment should necessarily be the preferred first-line therapy for such patients.http://www.sciencedirect.com/science/article/pii/S266632872030033Xdental treatmentgranulomatous cheilitislong-term outcomeodontogenic infectionorofacial granulomatosisperiapical infection |
| spellingShingle | Minghui Wei, MM Cheng Xie, MD, PhD Yubo Liu, MM Yuhong Wang, MM Yuanyuan Wang, MM Xinwen Wang, MD, PhD Yuan Liu, MD, PhD Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in ChinaCapsule Summary JAAD International dental treatment granulomatous cheilitis long-term outcome odontogenic infection orofacial granulomatosis periapical infection |
| title | Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in ChinaCapsule Summary |
| title_full | Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in ChinaCapsule Summary |
| title_fullStr | Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in ChinaCapsule Summary |
| title_full_unstemmed | Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in ChinaCapsule Summary |
| title_short | Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in ChinaCapsule Summary |
| title_sort | characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in chinacapsule summary |
| topic | dental treatment granulomatous cheilitis long-term outcome odontogenic infection orofacial granulomatosis periapical infection |
| url | http://www.sciencedirect.com/science/article/pii/S266632872030033X |
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