Construction of an HLA Classifier for Early Diagnosis, Prognosis, and Recognition of Immunosuppression in Sepsis by Multiple Transcriptome Datasets

Construction of an HLA Classifier for Early Diagnosis, Prognosis, and Recognition of Immunosuppression in Sepsis by Multiple Transcriptome Datasets

Background: Sepsis is a clinical syndrome, due to a dysregulated inflammatory response to infection. Accumulating evidence shows that human leukocyte antigen (HLA) genes play a key role in the immune responses to sepsis. Nevertheless, the effects of HLA genes in sepsis have still not been comprehens...

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Hlavní autoři: Zhen Chen, Rui Chen, Yangpeng Ou, Jianhai Lu, Qianhua Jiang, Genglong Liu, Liping Wang, Yayun Liu, Zhujiang Zhou, Ben Yang, Liuer Zuo
Médium: Článek
Jazyk:English
Vydáno: Frontiers Media S.A. 2022-05-01
Edice:Frontiers in Physiology
Témata:
sepsis
HLA genes
immune infiltration
immunosuppression
model
On-line přístup:https://www.frontiersin.org/articles/10.3389/fphys.2022.870657/full

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