A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

Most of the cholesterol in the plasma membranes (PMs) of animal cells is sequestered through interactions with phospholipids and transmembrane domains of proteins. However, as cholesterol concentration rises above the PM’s sequestration capacity, a new pool of cholesterol, called accessible choleste...

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Bibliographic Details
Main Authors: David B Heisler, Kristen A Johnson, Duo H Ma, Maikke B Ohlson, Lishu Zhang, Michelle Tran, Chase D Corley, Michael E Abrams, Jeffrey G McDonald, John W Schoggins, Neal M Alto, Arun Radhakrishnan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
Listeria monocytogenes
Zika virus
coronavirus
plasma membrane
endoplasmic reticulum
Online Access:https://elifesciences.org/articles/83534

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