A mRNA Vaccine Encoding for a RBD 60-mer Nanoparticle Elicits Neutralizing Antibodies and Protective Immunity Against the SARS-CoV-2 Delta Variant in Transgenic K18-hACE2 Mice

A mRNA Vaccine Encoding for a RBD 60-mer Nanoparticle Elicits Neutralizing Antibodies and Protective Immunity Against the SARS-CoV-2 Delta Variant in Transgenic K18-hACE2 Mice

Two years into the COVID-19 pandemic there is still a need for vaccines to effectively control the spread of novel SARS-CoV-2 variants and associated cases of severe disease. Here we report a messenger RNA vaccine directly encoding for a nanoparticle displaying 60 receptor binding domains (RBDs) of...

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Bibliographic Details
Main Authors: Pascal Brandys, Xavier Montagutelli, Irena Merenkova, Güliz T. Barut, Volker Thiel, Nicholas J. Schork, Bettina Trüeb, Laurine Conquet, Aihua Deng, Aleksandar Antanasijevic, Hyun-Ku Lee, Martine Valière, Anoop Sindhu, Gita Singh, Jens Herold
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
delta variant
mRNA vaccine
nanoparticle
receptor-binding domain
neutralizing antibody
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.912898/full

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