Efficacy of Glucagon-Like Peptide-1 Analogs in Nonalcoholic Fatty Liver Disease: A Systematic Review
Getnet Teshome,1 Sintayehu Ambachew,2 Alebachew Fasil,2 Molla Abebe2 1University of Gondar Comprehensive Specialized Hospital, University of Gondar, Gondar, Amhara, Ethiopia; 2Department of Clinical Chemistry, University of Gondar, Gondar, Amhara, EthiopiaCorrespondence: Getnet TeshomeUniversity of...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-09-01
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| Series: | Hepatic Medicine: Evidence and Research |
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| Online Access: | https://www.dovepress.com/efficacy-of-glucagon-like-peptide-1-analogs-in-nonalcoholic-fatty-live-peer-reviewed-article-HMER |
| _version_ | 1818681270383673344 |
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| author | Teshome G Ambachew S Fasil A Abebe M |
| author_facet | Teshome G Ambachew S Fasil A Abebe M |
| author_sort | Teshome G |
| collection | DOAJ |
| description | Getnet Teshome,1 Sintayehu Ambachew,2 Alebachew Fasil,2 Molla Abebe2 1University of Gondar Comprehensive Specialized Hospital, University of Gondar, Gondar, Amhara, Ethiopia; 2Department of Clinical Chemistry, University of Gondar, Gondar, Amhara, EthiopiaCorrespondence: Getnet TeshomeUniversity of Gondar Comprehensive Specialized Hospital, University of Gondar, Gondar, Amhara, EthiopiaEmail getnetfetene44@gmail.comBackground: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. It is believed to be the hepatic manifestation of the metabolic syndrome. Many treatment approaches have been suggested so far, and several types of studies have been done to find treatment for NAFLD, the most promising of which are those with lifestyle interventions.Objective: The aim of this systematic review was to evaluate the efficacy and safety of glucagon-like peptide-1 (GLP-1) analogs on the management of NAFLD.Methods: The PubMed, MEDLINE, and Cochrane Central Library were searched to identify randomized controlled trials, single arm trials, and cohorts that compared GLP-1 analogs with a control treatment or baseline values with respect to efficacy and safety in patients living with NAFLD. The key outcomes were a change in serum transaminase, resolution of disease status measured by imaging or histological techniques, improvement in insulin resistance, and reduction in body weight.Results: Initial searching retrieved 201 peer-reviewed articles and abstracts. Ten studies met all inclusion criteria. The review included a total of 590 participants with NAFLD. Following administration of GLP-1 analogs, a decrease in serum transaminases, improvement in liver histology and insulin resistance, and a reduction in body weight were observed. Compared with baseline, body weight, alanine aminotransferase, aspartate aminotransferase, and gamma glutamyltransferase were decreased by 5.5%, 59.5%, 52.8%, and 44.8%, respectively, due to GLP-1. Likewise, a reduction of proinflammatory cytokines and fibrosis markers and an enhancement of protective adipokines were observed in some of the studies.Conclusion: The decrease in a key biochemical marker of liver injury following treatment with GLP-1 analogs, as well as improvements in imaging and histology, suggests that these agents may be effective alternatives for managing NAFLD.Registration: CRD42018087262.Keywords: GLP-1RA, GLP-1 analogs, GLP-1 and NAFLD |
| first_indexed | 2024-12-17T10:00:17Z |
| format | Article |
| id | doaj.art-9ee83a335def4fcb878696f4dcd4d95e |
| institution | Directory Open Access Journal |
| issn | 1179-1535 |
| language | English |
| last_indexed | 2024-12-17T10:00:17Z |
| publishDate | 2020-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Hepatic Medicine: Evidence and Research |
| spelling | doaj.art-9ee83a335def4fcb878696f4dcd4d95e2022-12-21T21:53:18ZengDove Medical PressHepatic Medicine: Evidence and Research1179-15352020-09-01Volume 1213915157326Efficacy of Glucagon-Like Peptide-1 Analogs in Nonalcoholic Fatty Liver Disease: A Systematic ReviewTeshome GAmbachew SFasil AAbebe MGetnet Teshome,1 Sintayehu Ambachew,2 Alebachew Fasil,2 Molla Abebe2 1University of Gondar Comprehensive Specialized Hospital, University of Gondar, Gondar, Amhara, Ethiopia; 2Department of Clinical Chemistry, University of Gondar, Gondar, Amhara, EthiopiaCorrespondence: Getnet TeshomeUniversity of Gondar Comprehensive Specialized Hospital, University of Gondar, Gondar, Amhara, EthiopiaEmail getnetfetene44@gmail.comBackground: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. It is believed to be the hepatic manifestation of the metabolic syndrome. Many treatment approaches have been suggested so far, and several types of studies have been done to find treatment for NAFLD, the most promising of which are those with lifestyle interventions.Objective: The aim of this systematic review was to evaluate the efficacy and safety of glucagon-like peptide-1 (GLP-1) analogs on the management of NAFLD.Methods: The PubMed, MEDLINE, and Cochrane Central Library were searched to identify randomized controlled trials, single arm trials, and cohorts that compared GLP-1 analogs with a control treatment or baseline values with respect to efficacy and safety in patients living with NAFLD. The key outcomes were a change in serum transaminase, resolution of disease status measured by imaging or histological techniques, improvement in insulin resistance, and reduction in body weight.Results: Initial searching retrieved 201 peer-reviewed articles and abstracts. Ten studies met all inclusion criteria. The review included a total of 590 participants with NAFLD. Following administration of GLP-1 analogs, a decrease in serum transaminases, improvement in liver histology and insulin resistance, and a reduction in body weight were observed. Compared with baseline, body weight, alanine aminotransferase, aspartate aminotransferase, and gamma glutamyltransferase were decreased by 5.5%, 59.5%, 52.8%, and 44.8%, respectively, due to GLP-1. Likewise, a reduction of proinflammatory cytokines and fibrosis markers and an enhancement of protective adipokines were observed in some of the studies.Conclusion: The decrease in a key biochemical marker of liver injury following treatment with GLP-1 analogs, as well as improvements in imaging and histology, suggests that these agents may be effective alternatives for managing NAFLD.Registration: CRD42018087262.Keywords: GLP-1RA, GLP-1 analogs, GLP-1 and NAFLDhttps://www.dovepress.com/efficacy-of-glucagon-like-peptide-1-analogs-in-nonalcoholic-fatty-live-peer-reviewed-article-HMERglp-1raglp-1 analoguesglp-1 and nafld |
| spellingShingle | Teshome G Ambachew S Fasil A Abebe M Efficacy of Glucagon-Like Peptide-1 Analogs in Nonalcoholic Fatty Liver Disease: A Systematic Review Hepatic Medicine: Evidence and Research glp-1ra glp-1 analogues glp-1 and nafld |
| title | Efficacy of Glucagon-Like Peptide-1 Analogs in Nonalcoholic Fatty Liver Disease: A Systematic Review |
| title_full | Efficacy of Glucagon-Like Peptide-1 Analogs in Nonalcoholic Fatty Liver Disease: A Systematic Review |
| title_fullStr | Efficacy of Glucagon-Like Peptide-1 Analogs in Nonalcoholic Fatty Liver Disease: A Systematic Review |
| title_full_unstemmed | Efficacy of Glucagon-Like Peptide-1 Analogs in Nonalcoholic Fatty Liver Disease: A Systematic Review |
| title_short | Efficacy of Glucagon-Like Peptide-1 Analogs in Nonalcoholic Fatty Liver Disease: A Systematic Review |
| title_sort | efficacy of glucagon like peptide 1 analogs in nonalcoholic fatty liver disease a systematic review |
| topic | glp-1ra glp-1 analogues glp-1 and nafld |
| url | https://www.dovepress.com/efficacy-of-glucagon-like-peptide-1-analogs-in-nonalcoholic-fatty-live-peer-reviewed-article-HMER |
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