Ethanolamine Is a New Anti-Prion Compound

Ethanolamine Is a New Anti-Prion Compound

Prion diseases are a group of fatal neurodegenerative disorders caused by accumulation of proteinaceous infectious particles, or prions, which mainly consist of the abnormally folded, amyloidogenic prion protein, designated PrP<sup>Sc</sup>. PrP<sup>Sc</sup> is produced throu...

Full description

Bibliographic Details
Main Authors:	Keiji Uchiyama, Hideyuki Hara, Junji Chida, Agriani Dini Pasiana, Morikazu Imamura, Tsuyoshi Mori, Hanae Takatsuki, Ryuichiro Atarashi, Suehiro Sakaguchi
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Series:	International Journal of Molecular Sciences
Subjects:	prions prion protein protein misfolding neurodegeneration ethanolamine therapy
Online Access:	https://www.mdpi.com/1422-0067/22/21/11742

Similar Items

Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91–106
by: Keiji Uchiyama, et al.
Published: (2020-10-01)

N-Terminal Regions of Prion Protein: Functions and Roles in Prion Diseases
by: Hideyuki Hara, et al.
Published: (2020-08-01)

Vaporized Hydrogen Peroxide and Ozone Gas Synergistically Reduce Prion Infectivity on Stainless Steel Wire
by: Hideyuki Hara, et al.
Published: (2021-03-01)

Recombinant Mammalian Prions: The “Correctly” Misfolded Prion Protein Conformers
by: Jiyan Ma, et al.
Published: (2022-08-01)

Virus Infection, Genetic Mutations, and Prion Infection in Prion Protein Conversion
by: Hideyuki Hara, et al.
Published: (2021-11-01)

The first non-prion pathogen identified: neurotropic influenza virus
by: Suehiro Sakaguchi, et al.
Published: (2022-12-01)

Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing
by: Courtney L Klaips, et al.
Published: (2014-12-01)

Proteostasis unbalance in prion diseases: Mechanisms of neurodegeneration and therapeutic targets
by: Stefano Thellung, et al.
Published: (2022-09-01)

Disease Transmission by Misfolded Prion-Protein Isoforms, Prion-Like Amyloids, Functional Amyloids and the Central Dogma
by: Martin L. Daus
Published: (2016-01-01)

A single amino acid (Asp159) from the dog prion protein suppresses the toxicity of the mouse prion protein in Drosophila
by: J. Sanchez-Garcia, et al.
Published: (2016-11-01)

Prion Diseases: A Unique Transmissible Agent or a Model for Neurodegenerative Diseases?
by: Diane L. Ritchie, et al.
Published: (2021-02-01)

Prions : the new biology of proteins /
by: Soto, Claudio
Published: (2006)

Understanding and exploiting interactions between cellular proteostasis pathways and infectious prion proteins for therapeutic benefit
by: Unekwu M. Yakubu, et al.
Published: (2020-11-01)

From Seeds to Fibrils and Back: Fragmentation as an Overlooked Step in the Propagation of Prions and Prion-Like Proteins
by: Cristóbal Marrero-Winkens, et al.
Published: (2020-09-01)

Ex vivo mammalian prions are formed of paired double helical prion protein fibrils
by: Cassandra Terry, et al.
Published: (2016-01-01)

Cyclophillin A deficiency accelerates RML-induced prion disease
by: Ihssane Bouybayoune, et al.
Published: (2019-10-01)

The Effect of Octapeptide Repeats on Prion Folding and Misfolding
by: Kun-Hua Yu, et al.
Published: (2021-02-01)

Copper coordination modulates prion conversion and infectivity in mammalian prion proteins
by: Giuseppe Legname
Published: (2023-12-01)

Prion in Saliva of Bovine Spongiform Encephalopathy–Infected Cattle
by: Hiroyuki Okada, et al.
Published: (2012-12-01)

Prion-Like Proteins in Phase Separation and Their Link to Disease
by: Macy L. Sprunger, et al.
Published: (2021-07-01)

Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in Neurodegeneration
by: Carlo Scialò, et al.
Published: (2019-03-01)

Real-Time Quaking-Induced Conversion Detection of Bovine Spongiform Encephalopathy Prions in a Subclinical Steer
by: Soyoun Hwang, et al.
Published: (2018-01-01)

Polymorphism of amyloid-like fibrils can be defined by the concentration of seeds
by: Tomas Sneideris, et al.
Published: (2015-08-01)

Prion protein protocols /
by: Hill, Andrew F.
Published: (2008)

Therapeutic implications of prion diseases
by: Cao Chen, et al.
Published: (2021-04-01)

Development of a methodology for large-scale production of prions for biological and structural studies
by: Luis Concha-Marambio, et al.
Published: (2023-08-01)

Susceptibility of Human Prion Protein to Conversion by Chronic Wasting Disease Prions
by: Marcelo A. Barria, et al.
Published: (2018-08-01)

In vitro prion-like behaviour of TDP-43 in ALS
by: Phillip Smethurst, et al.
Published: (2016-12-01)

Microglia in Prion Diseases: Angels or Demons?
by: Caterina Peggion, et al.
Published: (2020-10-01)

The First Report of the Prion Protein Gene (<i>PRNP</i>) Sequence in Pekin Ducks (<i>Anas platyrhynchos domestica</i>): The Potential Prion Disease Susceptibility in Ducks
by: Min-Ju Jeong, et al.
Published: (2021-01-01)

Prions and prion diseases : new developments /
by: Verdier, Jean-Michel
Published: (2012)

The architecture of prions: how understanding would provide new therapeutic insights
by: Hasier Eraña, et al.
Published: (2016-09-01)

Searching for Factors that Distinguish Disease-Prone and Disease-Resistant Prions via Sequence Analysis
by: Lukasz Kurgan, et al.
Published: (2008-01-01)

Reversible symptoms and clearance of mutant prion protein in an inducible model of a genetic prion disease in Drosophila melanogaster
by: A. Murali, et al.
Published: (2014-07-01)

The cellular prion protein beyond prion diseases
by: Giorgia Manni, et al.
Published: (2020-04-01)

The prion-like transmission of tau oligomers via exosomes
by: Noel A. Jackson, et al.
Published: (2022-08-01)

Doxycycline rescues recognition memory and circadian motor rhythmicity but does not prevent terminal disease in fatal familial insomnia mice
by: Giada Lavigna, et al.
Published: (2021-10-01)

Extensive accumulation of misfolded protein aggregates during natural aging and senescence
by: Karina Cuanalo-Contreras, et al.
Published: (2023-01-01)

POSCAbilities: The Application of the Prion Organotypic Slice Culture Assay to Neurodegenerative Disease Research
by: Hailey Pineau, et al.
Published: (2020-07-01)

Creutzfeldt-Jakob disease after COVID-19: infection-induced prion protein misfolding? A case report
by: Andrea Bernardini, et al.
Published: (2022-12-01)