Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults
Abstract Corin, a transmembrane serine protease that can cleave pro‐atrial natriuretic peptide (Pro‐ANP) into smaller bioactive molecule atrial natriuretic peptide, has been shown to be involved in the pathophysiology of hypertension, cardiac hypertrophy. We sought to examine the associations of cor...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-12-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14401 |
| _version_ | 1797645247116738560 |
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| author | Ting Zou Shi Yao Ming‐Fei Du Jian‐Jun Mu Chao Chu Gui‐Lin Hu Yue‐Yuan Liao Chen Chen Dan Wang Qiong Ma Yu Yan Hao Jia Ke‐Ke Wang Yue Sun Ze‐Jiaxin Niu Xi Zhang Rui‐Chen Yan Zi‐Yue Man Dan‐Feng Ren Lan Wang Wei‐Hua Gao Hao Li Yong‐Xing Wu Chun‐Hua Li Ke Gao Jie Zhang Tie‐Lin Yang Yang Wang |
| author_facet | Ting Zou Shi Yao Ming‐Fei Du Jian‐Jun Mu Chao Chu Gui‐Lin Hu Yue‐Yuan Liao Chen Chen Dan Wang Qiong Ma Yu Yan Hao Jia Ke‐Ke Wang Yue Sun Ze‐Jiaxin Niu Xi Zhang Rui‐Chen Yan Zi‐Yue Man Dan‐Feng Ren Lan Wang Wei‐Hua Gao Hao Li Yong‐Xing Wu Chun‐Hua Li Ke Gao Jie Zhang Tie‐Lin Yang Yang Wang |
| author_sort | Ting Zou |
| collection | DOAJ |
| description | Abstract Corin, a transmembrane serine protease that can cleave pro‐atrial natriuretic peptide (Pro‐ANP) into smaller bioactive molecule atrial natriuretic peptide, has been shown to be involved in the pathophysiology of hypertension, cardiac hypertrophy. We sought to examine the associations of corin genetic variations with salt sensitivity, blood pressure (BP) changes and hypertension incidence. We studied participants of the original Baoji Salt‐Sensitive cohort, recruited from 124 families from seven Chinese villages in 2004 who sequentially received a usual baseline salt diet, a 7‐day low salt diet (3 g/day) and a 7‐day high salt diet (18 g/day), respectively. They were followed up for 8 years (in 2009, 2012) to evaluate the development of hypertension. Corin SNP rs3749584 was significantly associated with diastolic BP (DBP) and mean arterial pressure (MAP) response to low‐salt diet, while rs4695253, rs17654278 were associated with pulse pressure (PP) response to low‐salt diet. SNPs rs4695253, rs12509275, rs2351783, rs2271036, rs2271037 were significantly associated with systolic BP (SBP), DBP, and MAP responses to high‐salt diet. In addition, SNPs rs12641823, rs6834933, rs2271036, and rs22710367 were significantly associated with the longitudinal changes in SBP, DBP, MAP, or PP over 8 years of follow‐up. SNP rs73814824 was significantly associated with the incidence of hypertension over 8 years. Gene‐based analysis showed that corin gene was significantly associated with longitudinal BP changes and hypertension incidence after 8‐year follow‐up. This study suggests that corin may play a role in salt sensitivity, BP progression, and development of hypertension. |
| first_indexed | 2024-03-11T14:43:35Z |
| format | Article |
| id | doaj.art-9ee8e9ac38344930b66e2ffb36ffad7d |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:43:35Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-9ee8e9ac38344930b66e2ffb36ffad7d2023-10-30T13:26:28ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762021-12-0123122115212310.1111/jch.14401Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adultsTing Zou0Shi Yao1Ming‐Fei Du2Jian‐Jun Mu3Chao Chu4Gui‐Lin Hu5Yue‐Yuan Liao6Chen Chen7Dan Wang8Qiong Ma9Yu Yan10Hao Jia11Ke‐Ke Wang12Yue Sun13Ze‐Jiaxin Niu14Xi Zhang15Rui‐Chen Yan16Zi‐Yue Man17Dan‐Feng Ren18Lan Wang19Wei‐Hua Gao20Hao Li21Yong‐Xing Wu22Chun‐Hua Li23Ke Gao24Jie Zhang25Tie‐Lin Yang26Yang Wang27Department of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaNational and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy Second Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Infectious Diseases the First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiology Xi'an International Medical Center Hospital Xi'an ChinaDepartment of Cardiology Xi'an No.1 Hospital Xi'an ChinaDepartment of Critical Care Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Critical Care Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Ophthalmology Xi'an People's Hospital Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Cardiology Xi'an People's Hospital Xi'an ChinaBiomedical Informatics & Genomics Center School of Life Science and Technology Xi'an Jiaotong University Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaAbstract Corin, a transmembrane serine protease that can cleave pro‐atrial natriuretic peptide (Pro‐ANP) into smaller bioactive molecule atrial natriuretic peptide, has been shown to be involved in the pathophysiology of hypertension, cardiac hypertrophy. We sought to examine the associations of corin genetic variations with salt sensitivity, blood pressure (BP) changes and hypertension incidence. We studied participants of the original Baoji Salt‐Sensitive cohort, recruited from 124 families from seven Chinese villages in 2004 who sequentially received a usual baseline salt diet, a 7‐day low salt diet (3 g/day) and a 7‐day high salt diet (18 g/day), respectively. They were followed up for 8 years (in 2009, 2012) to evaluate the development of hypertension. Corin SNP rs3749584 was significantly associated with diastolic BP (DBP) and mean arterial pressure (MAP) response to low‐salt diet, while rs4695253, rs17654278 were associated with pulse pressure (PP) response to low‐salt diet. SNPs rs4695253, rs12509275, rs2351783, rs2271036, rs2271037 were significantly associated with systolic BP (SBP), DBP, and MAP responses to high‐salt diet. In addition, SNPs rs12641823, rs6834933, rs2271036, and rs22710367 were significantly associated with the longitudinal changes in SBP, DBP, MAP, or PP over 8 years of follow‐up. SNP rs73814824 was significantly associated with the incidence of hypertension over 8 years. Gene‐based analysis showed that corin gene was significantly associated with longitudinal BP changes and hypertension incidence after 8‐year follow‐up. This study suggests that corin may play a role in salt sensitivity, BP progression, and development of hypertension.https://doi.org/10.1111/jch.14401blood pressurecoringene polymorphismsalt sensitivitysalt |
| spellingShingle | Ting Zou Shi Yao Ming‐Fei Du Jian‐Jun Mu Chao Chu Gui‐Lin Hu Yue‐Yuan Liao Chen Chen Dan Wang Qiong Ma Yu Yan Hao Jia Ke‐Ke Wang Yue Sun Ze‐Jiaxin Niu Xi Zhang Rui‐Chen Yan Zi‐Yue Man Dan‐Feng Ren Lan Wang Wei‐Hua Gao Hao Li Yong‐Xing Wu Chun‐Hua Li Ke Gao Jie Zhang Tie‐Lin Yang Yang Wang Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults The Journal of Clinical Hypertension blood pressure corin gene polymorphism salt sensitivity salt |
| title | Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults |
| title_full | Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults |
| title_fullStr | Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults |
| title_full_unstemmed | Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults |
| title_short | Associations of corin genetic polymorphisms with salt sensitivity, blood pressure changes, and hypertension incidence in Chinese adults |
| title_sort | associations of corin genetic polymorphisms with salt sensitivity blood pressure changes and hypertension incidence in chinese adults |
| topic | blood pressure corin gene polymorphism salt sensitivity salt |
| url | https://doi.org/10.1111/jch.14401 |
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