From Self-Assembly of Colloidal Crystals toward Ordered Porous Layer Interferometry
Interferometry-based, reflectometric, label-free biosensors have made significant progress in the analysis of molecular interactions after years of development. The design of interference substrates is a key research topic for these biosensors, and many studies have focused on porous films prepared...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/13/7/730 |
| _version_ | 1827733697993900032 |
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| author | Yi-Zhen Wan Weiping Qian |
| author_facet | Yi-Zhen Wan Weiping Qian |
| author_sort | Yi-Zhen Wan |
| collection | DOAJ |
| description | Interferometry-based, reflectometric, label-free biosensors have made significant progress in the analysis of molecular interactions after years of development. The design of interference substrates is a key research topic for these biosensors, and many studies have focused on porous films prepared by top-down methods such as porous silicon and anodic aluminum oxide. Lately, more research has been conducted on ordered porous layer interferometry (OPLI), which uses ordered porous colloidal crystal films as interference substrates. These films are made using self-assembly techniques, which is the bottom-up approach. They also offer several advantages for biosensing applications, such as budget cost, adjustable porosity, and high structural consistency. This review will briefly explain the fundamental components of self-assembled materials and thoroughly discuss various self-assembly techniques in depth. We will also summarize the latest studies that used the OPLI technique for label-free biosensing applications and divide them into several aspects for further discussion. Then, we will comprehensively evaluate the strengths and weaknesses of self-assembly techniques and discuss possible future research directions. Finally, we will outlook the upcoming challenges and opportunities for label-free biosensing using the OPLI technique. |
| first_indexed | 2024-03-11T01:15:49Z |
| format | Article |
| id | doaj.art-9eeb76f781fa436799b8152d001dd731 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-11T01:15:49Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-9eeb76f781fa436799b8152d001dd7312023-11-18T18:33:12ZengMDPI AGBiosensors2079-63742023-07-0113773010.3390/bios13070730From Self-Assembly of Colloidal Crystals toward Ordered Porous Layer InterferometryYi-Zhen Wan0Weiping Qian1State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, ChinaState Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, ChinaInterferometry-based, reflectometric, label-free biosensors have made significant progress in the analysis of molecular interactions after years of development. The design of interference substrates is a key research topic for these biosensors, and many studies have focused on porous films prepared by top-down methods such as porous silicon and anodic aluminum oxide. Lately, more research has been conducted on ordered porous layer interferometry (OPLI), which uses ordered porous colloidal crystal films as interference substrates. These films are made using self-assembly techniques, which is the bottom-up approach. They also offer several advantages for biosensing applications, such as budget cost, adjustable porosity, and high structural consistency. This review will briefly explain the fundamental components of self-assembled materials and thoroughly discuss various self-assembly techniques in depth. We will also summarize the latest studies that used the OPLI technique for label-free biosensing applications and divide them into several aspects for further discussion. Then, we will comprehensively evaluate the strengths and weaknesses of self-assembly techniques and discuss possible future research directions. Finally, we will outlook the upcoming challenges and opportunities for label-free biosensing using the OPLI technique.https://www.mdpi.com/2079-6374/13/7/730self-assemblycolloidal crystalsreflectometryoptical interferometryordered porous layer interferometrybiosensors |
| spellingShingle | Yi-Zhen Wan Weiping Qian From Self-Assembly of Colloidal Crystals toward Ordered Porous Layer Interferometry Biosensors self-assembly colloidal crystals reflectometry optical interferometry ordered porous layer interferometry biosensors |
| title | From Self-Assembly of Colloidal Crystals toward Ordered Porous Layer Interferometry |
| title_full | From Self-Assembly of Colloidal Crystals toward Ordered Porous Layer Interferometry |
| title_fullStr | From Self-Assembly of Colloidal Crystals toward Ordered Porous Layer Interferometry |
| title_full_unstemmed | From Self-Assembly of Colloidal Crystals toward Ordered Porous Layer Interferometry |
| title_short | From Self-Assembly of Colloidal Crystals toward Ordered Porous Layer Interferometry |
| title_sort | from self assembly of colloidal crystals toward ordered porous layer interferometry |
| topic | self-assembly colloidal crystals reflectometry optical interferometry ordered porous layer interferometry biosensors |
| url | https://www.mdpi.com/2079-6374/13/7/730 |
| work_keys_str_mv | AT yizhenwan fromselfassemblyofcolloidalcrystalstowardorderedporouslayerinterferometry AT weipingqian fromselfassemblyofcolloidalcrystalstowardorderedporouslayerinterferometry |