Trends of anti-seizure medication prescribing pattern in traumatic brain injury patients for the prevention of posttraumatic seizure in Taiwan
Traumatic brain injury (TBI) patients are recommended to receive anti-seizure medication (ASM) as posttraumatic seizure (PTS) prophylaxis. However, the utilization of ASM, including the prescription patterns and associated clinical characteristics, is limited in Taiwan. Thus, this study aimed to inv...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Epilepsy & Behavior Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589986424000194 |
| _version_ | 1797235550080466944 |
|---|---|
| author | Hsin-Tien Lee Fen-Fen Liao Sui-Sum Kung Shang-Jyh Hwang Kun-Pin Hsieh |
| author_facet | Hsin-Tien Lee Fen-Fen Liao Sui-Sum Kung Shang-Jyh Hwang Kun-Pin Hsieh |
| author_sort | Hsin-Tien Lee |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) patients are recommended to receive anti-seizure medication (ASM) as posttraumatic seizure (PTS) prophylaxis. However, the utilization of ASM, including the prescription patterns and associated clinical characteristics, is limited in Taiwan. Thus, this study aimed to investigate the ASM trends and clinical characteristics. This retrospective cohort study enrolled TBI patients who received levetiracetam, phenytoin, and valproic acid during hospitalization using the National Health Insurance Research Database between 2012 and 2019. The primary outcome was the trend of the ASMs based on the index year. The duration of levetiracetam prescription was categorized as short-term (seven days or less) or long-term (more than seven days). Logistic regression identified the factors associated with long-term usage. A total of 64,461 TBI patients were included. Levetiracetam usage increased yearly, while phenytoin declined. Among the levetiracetam users, 5681 (30.38%) were short-term users, and 13,016 (69.62%) were long-term users. Diagnoses of contusions, intracranial hemorrhage, other intracranial injuries, receiving operations, and a history of cerebrovascular disease were significantly associated with longer duration. Conclusions This study revealed the rising trend of levetiracetam usage, indicating its potential as an alternative to phenytoin. TBI patients with more severe conditions were more likely to receive longer prescriptions. |
| first_indexed | 2024-04-24T16:49:44Z |
| format | Article |
| id | doaj.art-9eebd10f09654caeabe7ad60bb4f2762 |
| institution | Directory Open Access Journal |
| issn | 2589-9864 |
| language | English |
| last_indexed | 2024-04-24T16:49:44Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Epilepsy & Behavior Reports |
| spelling | doaj.art-9eebd10f09654caeabe7ad60bb4f27622024-03-29T05:51:05ZengElsevierEpilepsy & Behavior Reports2589-98642024-01-0126100662Trends of anti-seizure medication prescribing pattern in traumatic brain injury patients for the prevention of posttraumatic seizure in TaiwanHsin-Tien Lee0Fen-Fen Liao1Sui-Sum Kung2Shang-Jyh Hwang3Kun-Pin Hsieh4Master Program in Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 100, Shin-Chuan 1st Road, Kaohsiung City 80708, TaiwanDepartment of Pharmacy, Kaohsiung Medical University Hospital, 100, Shin-Chuan 1st Road, Kaohsiung City 80708, TaiwanDivision of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, 100, Shin-Chuan 1st Road, Kaohsiung City 80708, TaiwanSchool of Medicine, College of Medicine, Kaohsiung Medical University, 100, Shin-Chuan 1st Road, Kaohsiung City 80708, Taiwan; Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100, Shin-Chuan 1st Road, Kaohsiung City 80708, Taiwan; Institute of Population Health Sciences, National Health Research Institutes, Zhunan Town, Miaoli County 350, TaiwanDepartment of Pharmacy, Kaohsiung Medical University Hospital, 100, Shin-Chuan 1st Road, Kaohsiung City 80708, Taiwan; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 100, Shin-Chuan 1st Road, Kaohsiung City 80708, Taiwan; Corresponding author at: School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Sanmin Dist., Kaohsiung City 80708, Taiwan.Traumatic brain injury (TBI) patients are recommended to receive anti-seizure medication (ASM) as posttraumatic seizure (PTS) prophylaxis. However, the utilization of ASM, including the prescription patterns and associated clinical characteristics, is limited in Taiwan. Thus, this study aimed to investigate the ASM trends and clinical characteristics. This retrospective cohort study enrolled TBI patients who received levetiracetam, phenytoin, and valproic acid during hospitalization using the National Health Insurance Research Database between 2012 and 2019. The primary outcome was the trend of the ASMs based on the index year. The duration of levetiracetam prescription was categorized as short-term (seven days or less) or long-term (more than seven days). Logistic regression identified the factors associated with long-term usage. A total of 64,461 TBI patients were included. Levetiracetam usage increased yearly, while phenytoin declined. Among the levetiracetam users, 5681 (30.38%) were short-term users, and 13,016 (69.62%) were long-term users. Diagnoses of contusions, intracranial hemorrhage, other intracranial injuries, receiving operations, and a history of cerebrovascular disease were significantly associated with longer duration. Conclusions This study revealed the rising trend of levetiracetam usage, indicating its potential as an alternative to phenytoin. TBI patients with more severe conditions were more likely to receive longer prescriptions.http://www.sciencedirect.com/science/article/pii/S2589986424000194Anti-seizure medicationLevetiracetamPosttraumatic seizureTraumatic brain injury |
| spellingShingle | Hsin-Tien Lee Fen-Fen Liao Sui-Sum Kung Shang-Jyh Hwang Kun-Pin Hsieh Trends of anti-seizure medication prescribing pattern in traumatic brain injury patients for the prevention of posttraumatic seizure in Taiwan Epilepsy & Behavior Reports Anti-seizure medication Levetiracetam Posttraumatic seizure Traumatic brain injury |
| title | Trends of anti-seizure medication prescribing pattern in traumatic brain injury patients for the prevention of posttraumatic seizure in Taiwan |
| title_full | Trends of anti-seizure medication prescribing pattern in traumatic brain injury patients for the prevention of posttraumatic seizure in Taiwan |
| title_fullStr | Trends of anti-seizure medication prescribing pattern in traumatic brain injury patients for the prevention of posttraumatic seizure in Taiwan |
| title_full_unstemmed | Trends of anti-seizure medication prescribing pattern in traumatic brain injury patients for the prevention of posttraumatic seizure in Taiwan |
| title_short | Trends of anti-seizure medication prescribing pattern in traumatic brain injury patients for the prevention of posttraumatic seizure in Taiwan |
| title_sort | trends of anti seizure medication prescribing pattern in traumatic brain injury patients for the prevention of posttraumatic seizure in taiwan |
| topic | Anti-seizure medication Levetiracetam Posttraumatic seizure Traumatic brain injury |
| url | http://www.sciencedirect.com/science/article/pii/S2589986424000194 |
| work_keys_str_mv | AT hsintienlee trendsofantiseizuremedicationprescribingpatternintraumaticbraininjurypatientsforthepreventionofposttraumaticseizureintaiwan AT fenfenliao trendsofantiseizuremedicationprescribingpatternintraumaticbraininjurypatientsforthepreventionofposttraumaticseizureintaiwan AT suisumkung trendsofantiseizuremedicationprescribingpatternintraumaticbraininjurypatientsforthepreventionofposttraumaticseizureintaiwan AT shangjyhhwang trendsofantiseizuremedicationprescribingpatternintraumaticbraininjurypatientsforthepreventionofposttraumaticseizureintaiwan AT kunpinhsieh trendsofantiseizuremedicationprescribingpatternintraumaticbraininjurypatientsforthepreventionofposttraumaticseizureintaiwan |