Central Circadian Control of Female Reproductive Function
Over the past two decades, it has become clear just how much of our physiology is under the control of the suprachiasmatic nucleus (SCN) and the cell-intrinsic molecular clock that ticks with a periodicity of approximately 24 hours. The SCN prepares our digestive system for meals, our adrenal axis f...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00195/full |
| _version_ | 1818991958544089088 |
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| author | Brooke H Miller Joseph S Takahashi |
| author_facet | Brooke H Miller Joseph S Takahashi |
| author_sort | Brooke H Miller |
| collection | DOAJ |
| description | Over the past two decades, it has become clear just how much of our physiology is under the control of the suprachiasmatic nucleus (SCN) and the cell-intrinsic molecular clock that ticks with a periodicity of approximately 24 hours. The SCN prepares our digestive system for meals, our adrenal axis for the stress of waking up in the morning, and the genes expressed in our muscles when we prepare to exercise, Long before molecular studies of genes such as Clock, Bmal1, and the Per homologs were possible, it was obvious that female reproductive function was under strict circadian control at every level of the hypothalamic-pituitary-gonadal (HPG) axis, and in the establishment and successful maintenance of pregnancy. This review highlights our current understanding of the role that the SCN plays in regulating female reproductive physiology, with a special emphasis on the advances made possible through the use of circadian mutant mice. |
| first_indexed | 2024-12-20T20:18:32Z |
| format | Article |
| id | doaj.art-9eed0a90e0ec45698abf9ab2baa90ed1 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-20T20:18:32Z |
| publishDate | 2014-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9eed0a90e0ec45698abf9ab2baa90ed12022-12-21T19:27:38ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922014-01-01410.3389/fendo.2013.0019569190Central Circadian Control of Female Reproductive FunctionBrooke H Miller0Joseph S Takahashi1University of Florida College of MedicineHoward Hughes Medical Institute, University of Texas Southwestern Medical CenterOver the past two decades, it has become clear just how much of our physiology is under the control of the suprachiasmatic nucleus (SCN) and the cell-intrinsic molecular clock that ticks with a periodicity of approximately 24 hours. The SCN prepares our digestive system for meals, our adrenal axis for the stress of waking up in the morning, and the genes expressed in our muscles when we prepare to exercise, Long before molecular studies of genes such as Clock, Bmal1, and the Per homologs were possible, it was obvious that female reproductive function was under strict circadian control at every level of the hypothalamic-pituitary-gonadal (HPG) axis, and in the establishment and successful maintenance of pregnancy. This review highlights our current understanding of the role that the SCN plays in regulating female reproductive physiology, with a special emphasis on the advances made possible through the use of circadian mutant mice.http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00195/fullCircadian RhythmEstrous CycleParturitionProestrusclock gene |
| spellingShingle | Brooke H Miller Joseph S Takahashi Central Circadian Control of Female Reproductive Function Frontiers in Endocrinology Circadian Rhythm Estrous Cycle Parturition Proestrus clock gene |
| title | Central Circadian Control of Female Reproductive Function |
| title_full | Central Circadian Control of Female Reproductive Function |
| title_fullStr | Central Circadian Control of Female Reproductive Function |
| title_full_unstemmed | Central Circadian Control of Female Reproductive Function |
| title_short | Central Circadian Control of Female Reproductive Function |
| title_sort | central circadian control of female reproductive function |
| topic | Circadian Rhythm Estrous Cycle Parturition Proestrus clock gene |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00195/full |
| work_keys_str_mv | AT brookehmiller centralcircadiancontroloffemalereproductivefunction AT josephstakahashi centralcircadiancontroloffemalereproductivefunction |