Dietary Pseudopurpurin Effects on Bone Mineral Density and Bone Geometry Architecture in Rats
The objective of our study was to evaluate whether feeding pseudopurpurin affects bone mineral density and bone geometry architecture in rats. Pseudopurpurin was extracted, analyzed and purified using an HLPC-ESI-MS. Rats were given 0% and 0.5% pseudopurpurin powder in their diet. Femurs of rats wer...
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MDPI AG
2012-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/13/3/3431/ |
| _version_ | 1811236322639085568 |
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| author | Zhe Wang Guo-Wen Liu Peng Li Chen-Chen Wu Xiao-Bing Li Wei-Zhong Wang Tie-Suo Han |
| author_facet | Zhe Wang Guo-Wen Liu Peng Li Chen-Chen Wu Xiao-Bing Li Wei-Zhong Wang Tie-Suo Han |
| author_sort | Zhe Wang |
| collection | DOAJ |
| description | The objective of our study was to evaluate whether feeding pseudopurpurin affects bone mineral density and bone geometry architecture in rats. Pseudopurpurin was extracted, analyzed and purified using an HLPC-ESI-MS. Rats were given 0% and 0.5% pseudopurpurin powder in their diet. Femurs of rats were examined at 0.5, 1 and 2 months after pseudopurpurin feeding. Compared with rats in the group 0%, the bone mineral density, and the calcium, magnesium, zinc and manganese concentrations in the rats femur in the group 0.5% increased significantly at 1 month and 2 months after pseudopurpurin feeding. Analytical results of micro-computed tomography showed that the group 0.5% displayed an increase in the trabecular volume fraction, trabecular thickness and trabecular number of the distal femur at 1 and 2 months after pseudopurpurin feeding, and the mean thickness, inner perimeter, outer perimeter, and area of the femur diaphysis were significantly increased at 2 months after pseudopurpurin feeding compared with the group 0%. In parallel, the trabecular separation and structure model index of the distal femur were decreased, compared with the group 0% at 1 and 2 months after pseudopurpurin feeding. In the 0.5% and 0% groups, there was no damage to kidney and liver by histopathology analysis. The long-term feeding of pseudopurpurin is safe for rats. The feeding of 0.5% pseudopurpurin which has specific chemical affinities for calcium for bone improvement and level of bone mineral density, enhances the geometry architecture compared with the 0% group. |
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| format | Article |
| id | doaj.art-9eed5bb050fe43aa9e140276df37a7ea |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T12:06:52Z |
| publishDate | 2012-03-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9eed5bb050fe43aa9e140276df37a7ea2022-12-22T03:33:41ZengMDPI AGInternational Journal of Molecular Sciences1422-00672012-03-011333431344310.3390/ijms13033431Dietary Pseudopurpurin Effects on Bone Mineral Density and Bone Geometry Architecture in RatsZhe WangGuo-Wen LiuPeng LiChen-Chen WuXiao-Bing LiWei-Zhong WangTie-Suo HanThe objective of our study was to evaluate whether feeding pseudopurpurin affects bone mineral density and bone geometry architecture in rats. Pseudopurpurin was extracted, analyzed and purified using an HLPC-ESI-MS. Rats were given 0% and 0.5% pseudopurpurin powder in their diet. Femurs of rats were examined at 0.5, 1 and 2 months after pseudopurpurin feeding. Compared with rats in the group 0%, the bone mineral density, and the calcium, magnesium, zinc and manganese concentrations in the rats femur in the group 0.5% increased significantly at 1 month and 2 months after pseudopurpurin feeding. Analytical results of micro-computed tomography showed that the group 0.5% displayed an increase in the trabecular volume fraction, trabecular thickness and trabecular number of the distal femur at 1 and 2 months after pseudopurpurin feeding, and the mean thickness, inner perimeter, outer perimeter, and area of the femur diaphysis were significantly increased at 2 months after pseudopurpurin feeding compared with the group 0%. In parallel, the trabecular separation and structure model index of the distal femur were decreased, compared with the group 0% at 1 and 2 months after pseudopurpurin feeding. In the 0.5% and 0% groups, there was no damage to kidney and liver by histopathology analysis. The long-term feeding of pseudopurpurin is safe for rats. The feeding of 0.5% pseudopurpurin which has specific chemical affinities for calcium for bone improvement and level of bone mineral density, enhances the geometry architecture compared with the 0% group.http://www.mdpi.com/1422-0067/13/3/3431/pseudopurpurinbone mineral densitybone mineral elementsbone geometry architecture |
| spellingShingle | Zhe Wang Guo-Wen Liu Peng Li Chen-Chen Wu Xiao-Bing Li Wei-Zhong Wang Tie-Suo Han Dietary Pseudopurpurin Effects on Bone Mineral Density and Bone Geometry Architecture in Rats International Journal of Molecular Sciences pseudopurpurin bone mineral density bone mineral elements bone geometry architecture |
| title | Dietary Pseudopurpurin Effects on Bone Mineral Density and Bone Geometry Architecture in Rats |
| title_full | Dietary Pseudopurpurin Effects on Bone Mineral Density and Bone Geometry Architecture in Rats |
| title_fullStr | Dietary Pseudopurpurin Effects on Bone Mineral Density and Bone Geometry Architecture in Rats |
| title_full_unstemmed | Dietary Pseudopurpurin Effects on Bone Mineral Density and Bone Geometry Architecture in Rats |
| title_short | Dietary Pseudopurpurin Effects on Bone Mineral Density and Bone Geometry Architecture in Rats |
| title_sort | dietary pseudopurpurin effects on bone mineral density and bone geometry architecture in rats |
| topic | pseudopurpurin bone mineral density bone mineral elements bone geometry architecture |
| url | http://www.mdpi.com/1422-0067/13/3/3431/ |
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