Taraxacum Officinale (Dandelion) Roots Extract Mitigates Doxorubicin-Induced HematoCardiotoxicity in Male Albino Rats
The present study was designed to evaluate the probable ameliorative effect of dandelion extract against doxorubicin hemato-cardiotoxicity. To accomplish this study, four groups of male albino rats (n=7) were used as follow, Group I: served as a control group, Group II: received dandelion extrac...
| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Veterinary Medicine, Beni-Suef University
2019-12-01
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| Series: | Journal of Veterinary Medical Research |
| Subjects: | |
| Online Access: | http://www.bsu.edu.eg/bsujournals/Content.aspx?paperId=3391&cat_id=1 |
| _version_ | 1818918673887264768 |
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| author | Dina R. S. Gad El-Karim |
| author_facet | Dina R. S. Gad El-Karim |
| author_sort | Dina R. S. Gad El-Karim |
| collection | DOAJ |
| description | The present study was designed to evaluate the probable ameliorative
effect of dandelion extract against doxorubicin hemato-cardiotoxicity. To
accomplish this study, four groups of male albino rats (n=7) were used as
follow, Group I: served as a control group, Group II: received dandelion
extract (200 mg/ kg), Group III: received doxorubicin (2.5 mg/kg) and Group
IV: received dandelion extract and doxorubicin identically to groups II and III.
Doxorubicin was administrated 3times/week for two consecutive weeks, while
dandelion extract was administrated daily for two consecutive weeks before
doxorubicin administration and continued during doxorubicin treatment. The
results illuminated that, administration of doxorubicin has a deleterious effect
on both of blood cellular components and cardiac tissues, which was indicated
by significant pancytopenia (decrease in all blood cell types), elevated serum
cardiac enzymes activity (CK-MB and LDH), increased serum level of cardiacrelated proteins (troponin I, atrial natriuretic peptide (ANP) and B-type
natriuretic peptide (BNP) with a depletion of cardiac tissues antioxidant (GSH,
and SOD enzyme) and elevated lipid peroxide (MDA) level in this tissues. Coadministration of dandelion extract with doxorubicin significantly alleviated its
hemato-cardiotoxic effect which was reflected positively on hematobiochemical changes and cardiac histopathological alterations. |
| first_indexed | 2024-12-20T00:53:42Z |
| format | Article |
| id | doaj.art-9eef7c0da40548289d0bf377dbb3ab75 |
| institution | Directory Open Access Journal |
| issn | 2357-0512 2357-0520 |
| language | English |
| last_indexed | 2024-12-20T00:53:42Z |
| publishDate | 2019-12-01 |
| publisher | Faculty of Veterinary Medicine, Beni-Suef University |
| record_format | Article |
| series | Journal of Veterinary Medical Research |
| spelling | doaj.art-9eef7c0da40548289d0bf377dbb3ab752022-12-21T19:59:10ZengFaculty of Veterinary Medicine, Beni-Suef UniversityJournal of Veterinary Medical Research2357-05122357-05202019-12-01262235246Taraxacum Officinale (Dandelion) Roots Extract Mitigates Doxorubicin-Induced HematoCardiotoxicity in Male Albino RatsDina R. S. Gad El-Karim0Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Alexandria University, Egypt.The present study was designed to evaluate the probable ameliorative effect of dandelion extract against doxorubicin hemato-cardiotoxicity. To accomplish this study, four groups of male albino rats (n=7) were used as follow, Group I: served as a control group, Group II: received dandelion extract (200 mg/ kg), Group III: received doxorubicin (2.5 mg/kg) and Group IV: received dandelion extract and doxorubicin identically to groups II and III. Doxorubicin was administrated 3times/week for two consecutive weeks, while dandelion extract was administrated daily for two consecutive weeks before doxorubicin administration and continued during doxorubicin treatment. The results illuminated that, administration of doxorubicin has a deleterious effect on both of blood cellular components and cardiac tissues, which was indicated by significant pancytopenia (decrease in all blood cell types), elevated serum cardiac enzymes activity (CK-MB and LDH), increased serum level of cardiacrelated proteins (troponin I, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) with a depletion of cardiac tissues antioxidant (GSH, and SOD enzyme) and elevated lipid peroxide (MDA) level in this tissues. Coadministration of dandelion extract with doxorubicin significantly alleviated its hemato-cardiotoxic effect which was reflected positively on hematobiochemical changes and cardiac histopathological alterations.http://www.bsu.edu.eg/bsujournals/Content.aspx?paperId=3391&cat_id=1anpbnpdandeliondoxorubicinhemato-cardiotoxicity |
| spellingShingle | Dina R. S. Gad El-Karim Taraxacum Officinale (Dandelion) Roots Extract Mitigates Doxorubicin-Induced HematoCardiotoxicity in Male Albino Rats Journal of Veterinary Medical Research anp bnp dandelion doxorubicin hemato-cardiotoxicity |
| title | Taraxacum Officinale (Dandelion) Roots Extract Mitigates Doxorubicin-Induced HematoCardiotoxicity in Male Albino Rats |
| title_full | Taraxacum Officinale (Dandelion) Roots Extract Mitigates Doxorubicin-Induced HematoCardiotoxicity in Male Albino Rats |
| title_fullStr | Taraxacum Officinale (Dandelion) Roots Extract Mitigates Doxorubicin-Induced HematoCardiotoxicity in Male Albino Rats |
| title_full_unstemmed | Taraxacum Officinale (Dandelion) Roots Extract Mitigates Doxorubicin-Induced HematoCardiotoxicity in Male Albino Rats |
| title_short | Taraxacum Officinale (Dandelion) Roots Extract Mitigates Doxorubicin-Induced HematoCardiotoxicity in Male Albino Rats |
| title_sort | taraxacum officinale dandelion roots extract mitigates doxorubicin induced hematocardiotoxicity in male albino rats |
| topic | anp bnp dandelion doxorubicin hemato-cardiotoxicity |
| url | http://www.bsu.edu.eg/bsujournals/Content.aspx?paperId=3391&cat_id=1 |
| work_keys_str_mv | AT dinarsgadelkarim taraxacumofficinaledandelionrootsextractmitigatesdoxorubicininducedhematocardiotoxicityinmalealbinorats |