Paeonol Protects Against Methotrexate-Induced Nephrotoxicity via Upregulation of P-gp Expression and Inhibition of TLR4/NF-κB Pathway

Paeonol Protects Against Methotrexate-Induced Nephrotoxicity via Upregulation of P-gp Expression and Inhibition of TLR4/NF-κB Pathway

Methotrexate (MTX) is a well-known anticancer drug that causes nephrotoxicity as a side effect. To investigate the mechanisms by which paeonol, a natural phenolic compound, can protect against MTX-induced nephrotoxicity, paeonol (100 mg/kg/day orally) was given to rats for 10 days, with or without M...

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Bibliographic Details
Main Authors: Mohamed A. Morsy, Azza A. K. El-Sheikh, Sara Mohamed Naguib Abdel-Hafez, Mahmoud Kandeel, Seham A. Abdel-Gaber
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
methotrexate
paeonol
P-glycoprotein
nephrotoxicity
KIM-1
TLR4
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.774387/full

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