Total tanshinones ameliorates cGAS-STING-mediated inflammatory and autoimmune diseases by affecting STING-IRF3 binding

Total tanshinones ameliorates cGAS-STING-mediated inflammatory and autoimmune diseases by affecting STING-IRF3 binding

Abstract Background An important signaling pathway connecting illness and natural immunity is the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, but aberrant activation of this pathway is associated with the development of autoimmune and inflammatory diseases. Hence,...

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Bibliographic Details
Main Authors: Chengwei Li, Jincai Wen, Xiaoyan Zhan, Wei Shi, Xiu Ye, Qing Yao, Simin Chen, Congyang Zheng, Xianlin Wang, Xinru Wen, Xiaohe Xiao, Yinghao Wang, Zhaofang Bai
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Chinese Medicine
Subjects:
Total tanshinones
Salvia miltiorrhiza
CGAS-STING
Autoimmune diseases
Acute liver injury
Inflammatory disease
Online Access:https://doi.org/10.1186/s13020-024-00980-4

Internet

https://doi.org/10.1186/s13020-024-00980-4

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