Spectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancers
Abstract Patients at risk of skin cancers can develop varying types of cutaneous malignancies. However, some subjects may develop only one type of lesion. In this cross-sectional study, the spectrum of premalignant (PM) and malignant skin lesions and their risk factors were studied. Therefore, 505 a...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-024-12035-w |
| _version_ | 1797259231990120448 |
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| author | Reetta Nevakivi Hanna Siiskonen Salla Haimakainen Ilkka T. Harvima |
| author_facet | Reetta Nevakivi Hanna Siiskonen Salla Haimakainen Ilkka T. Harvima |
| author_sort | Reetta Nevakivi |
| collection | DOAJ |
| description | Abstract Patients at risk of skin cancers can develop varying types of cutaneous malignancies. However, some subjects may develop only one type of lesion. In this cross-sectional study, the spectrum of premalignant (PM) and malignant skin lesions and their risk factors were studied. Therefore, 505 adult subjects (aged 21–79 years, 256 males and 249 females, 96 with immunosuppression) at risk of any type of skin cancer were examined for cutaneous malignancies, nevi, actinic keratoses, photodamage, and possible risk factors. First, 12 different groups were identified with a varying set of PM and/or malignant skin lesions. Next, 5 larger groups were formed from them: basal cell carcinoma (BCC) only, malignant melanoma (MM) only, squamous cell carcinoma (SCC) and/or PM, BCC + SCC and/or PM, and MM + keratinocyte carcinoma (KC) and/or PM. The groups with BCC or MM only were younger and showed less photodamage than the mixed groups, while SCC/PM showed similarity with them. In logistic regression analyses, the platelet-to-lymphocyte ratio was associated with an increased risk of concomitant KC (OR 1.028, p = 0.023) or SCC/PM (OR 1.009, p = 0.047) in subjects with MM or BCC, respectively. Actinic keratoses produced ORs 0.246–0.252 (p = 0.008–0.020) for BCC in subjects with SCC/PM. Interestingly, atypical mole syndrome decreased the risk of SCC/PM in subjects with BCC (OR 0.092, p = 0.001). Advanced age was a significant risk factor for an additional type of lesion in all 3 comparisons (ORs 1.088–1.388, p = 0.001). In conclusion, even though there are numerous patients with only one lesion type, advancing age may determine the final lesion multiplicity. |
| first_indexed | 2024-04-24T23:06:09Z |
| format | Article |
| id | doaj.art-9ef5656ddcc34747afe82974b5ab2f55 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-24T23:06:09Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-9ef5656ddcc34747afe82974b5ab2f552024-03-17T12:28:56ZengBMCBMC Cancer1471-24072024-03-0124111310.1186/s12885-024-12035-wSpectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancersReetta Nevakivi0Hanna Siiskonen1Salla Haimakainen2Ilkka T. Harvima3Department of Dermatology, University of Eastern Finland and Kuopio University HospitalDepartment of Dermatology, University of Eastern Finland and Kuopio University HospitalDepartment of Dermatology, University of Eastern Finland and Kuopio University HospitalDepartment of Dermatology, University of Eastern Finland and Kuopio University HospitalAbstract Patients at risk of skin cancers can develop varying types of cutaneous malignancies. However, some subjects may develop only one type of lesion. In this cross-sectional study, the spectrum of premalignant (PM) and malignant skin lesions and their risk factors were studied. Therefore, 505 adult subjects (aged 21–79 years, 256 males and 249 females, 96 with immunosuppression) at risk of any type of skin cancer were examined for cutaneous malignancies, nevi, actinic keratoses, photodamage, and possible risk factors. First, 12 different groups were identified with a varying set of PM and/or malignant skin lesions. Next, 5 larger groups were formed from them: basal cell carcinoma (BCC) only, malignant melanoma (MM) only, squamous cell carcinoma (SCC) and/or PM, BCC + SCC and/or PM, and MM + keratinocyte carcinoma (KC) and/or PM. The groups with BCC or MM only were younger and showed less photodamage than the mixed groups, while SCC/PM showed similarity with them. In logistic regression analyses, the platelet-to-lymphocyte ratio was associated with an increased risk of concomitant KC (OR 1.028, p = 0.023) or SCC/PM (OR 1.009, p = 0.047) in subjects with MM or BCC, respectively. Actinic keratoses produced ORs 0.246–0.252 (p = 0.008–0.020) for BCC in subjects with SCC/PM. Interestingly, atypical mole syndrome decreased the risk of SCC/PM in subjects with BCC (OR 0.092, p = 0.001). Advanced age was a significant risk factor for an additional type of lesion in all 3 comparisons (ORs 1.088–1.388, p = 0.001). In conclusion, even though there are numerous patients with only one lesion type, advancing age may determine the final lesion multiplicity.https://doi.org/10.1186/s12885-024-12035-wMalignant melanomaSquamous cell carcinomaBasal cell carcinomaActinic keratosisPlatelet-to-lymphocyte ratioPhotodamage |
| spellingShingle | Reetta Nevakivi Hanna Siiskonen Salla Haimakainen Ilkka T. Harvima Spectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancers BMC Cancer Malignant melanoma Squamous cell carcinoma Basal cell carcinoma Actinic keratosis Platelet-to-lymphocyte ratio Photodamage |
| title | Spectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancers |
| title_full | Spectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancers |
| title_fullStr | Spectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancers |
| title_full_unstemmed | Spectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancers |
| title_short | Spectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancers |
| title_sort | spectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancers |
| topic | Malignant melanoma Squamous cell carcinoma Basal cell carcinoma Actinic keratosis Platelet-to-lymphocyte ratio Photodamage |
| url | https://doi.org/10.1186/s12885-024-12035-w |
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