The association of physical activity and cardiorespiratory fitness with β-cell dysfunction, insulin resistance, and diabetes among adults in north-western Tanzania: A cross-sectional study
IntroductionResearch on the associations of physical activity and cardiorespiratory fitness with β-cell dysfunction and insulin resistance among adults in Sub-Saharan Africa (SSA) is limited. We assessed the association of physical activity and cardiorespiratory fitness with β-cell function, insulin...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.885988/full |
| _version_ | 1818010935310155776 |
|---|---|
| author | Brenda Kitilya Robert Peck Robert Peck Robert Peck John Changalucha Kidola Jeremiah Bazil B. Kavishe Henrik Friis Suzanne Filteau Rikke Krogh-Madsen Rikke Krogh-Madsen Soren Brage Daniel Faurholt-Jepsen Mette F. Olsen Mette F. Olsen George PrayGod |
| author_facet | Brenda Kitilya Robert Peck Robert Peck Robert Peck John Changalucha Kidola Jeremiah Bazil B. Kavishe Henrik Friis Suzanne Filteau Rikke Krogh-Madsen Rikke Krogh-Madsen Soren Brage Daniel Faurholt-Jepsen Mette F. Olsen Mette F. Olsen George PrayGod |
| author_sort | Brenda Kitilya |
| collection | DOAJ |
| description | IntroductionResearch on the associations of physical activity and cardiorespiratory fitness with β-cell dysfunction and insulin resistance among adults in Sub-Saharan Africa (SSA) is limited. We assessed the association of physical activity and cardiorespiratory fitness with β-cell function, insulin resistance and diabetes among people living with HIV (PLWH) ART-naïve and HIV-uninfected Tanzanian adults.MethodIn a cross-sectional study, we collected data on socio-demography, anthropometry, fat mass and fat free mass and C-reactive protein. Data on glucose and insulin collected during an oral glucose tolerance test were used to assess β-cell dysfunction (defined as insulinogenic index <0.71 (mU/L)/(mmol/L), HOMA-β index <38.3 (mU/L)/(mmol/L), and overall insulin release index <33.3 (mU/L)/(mmol/L)), oral disposition index <0.16 (mU/L)/(mg/dL)(mU/L)-1, insulin resistance (HOMA-IR index >1.9 (mU/L)/(mmol/L) and Matsuda index <7.2 (mU/L)/(mmol/L), prediabetes and diabetes which were the dependent variables. Physical activity energy expenditure (PAEE), sleeping heart rate (SHR), and maximum uptake of oxygen during exercise (VO2 max) were the independent variables and were assessed using a combined heart rate and accelerometer monitor. Logistic regressions were used to assess the associations.ResultsOf 391 participants, 272 were PLWH and 119 HIV-uninfected. The mean age was 39 ( ± 10.5) years and 60% (n=235) were females. Compared to lower tertile, middle tertile of PAEE was associated with lower odds of abnormal insulinogenic index (OR=0.48, 95%CI: 0.27, 0.82). A 5 kj/kg/day increment of PAEE was associated with lower odds of abnormal HOMA-IR (OR=0.91, 95%CI: 0.84, 0.98), and reduced risk of pre-diabetes (RRR=0.98, 95%CI: 0.96, 0.99) and diabetes (RRR=0.92, 95%CI: 0.88, 0.96). An increment of 5 beats per min of SHR was associated with higher risk of diabetes (RRR=1.06, 95%CI: 1.01, 1.11). An increase of 5 mLO2/kg/min of VO2 max was associated with lower risk of pre-diabetes (RRR=0.91, 95%CI: 0.86, 0.97), but not diabetes. HIV status did not modify any of these associations (interaction, p>0.05).ConclusionAmong Tanzanian adults PLWH and HIV-uninfected individuals, low physical activity was associated with β-cell dysfunction, insulin resistance and diabetes. Research is needed to assess if physical activity interventions can improve β-cell function and insulin sensitivity to reduce risk of diabetes and delay progression of diabetes in SSA. |
| first_indexed | 2024-04-14T06:01:52Z |
| format | Article |
| id | doaj.art-9ef7df378243411bae98a509e536f33f |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-14T06:01:52Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9ef7df378243411bae98a509e536f33f2022-12-22T02:08:44ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-08-011310.3389/fendo.2022.885988885988The association of physical activity and cardiorespiratory fitness with β-cell dysfunction, insulin resistance, and diabetes among adults in north-western Tanzania: A cross-sectional studyBrenda Kitilya0Robert Peck1Robert Peck2Robert Peck3John Changalucha4Kidola Jeremiah5Bazil B. Kavishe6Henrik Friis7Suzanne Filteau8Rikke Krogh-Madsen9Rikke Krogh-Madsen10Soren Brage11Daniel Faurholt-Jepsen12Mette F. Olsen13Mette F. Olsen14George PrayGod15Mwanza Research Centre, National Institute for Medical Research, Mwanza, TanzaniaMwanza Research Centre, National Institute for Medical Research, Mwanza, TanzaniaDepartment of Internal Medicine and Pediatrics, Weill Bugando School of Medicine, Mwanza, TanzaniaDepartment of Global Health, Weill Cornell Medicine, New York, NY, United StatesMwanza Research Centre, National Institute for Medical Research, Mwanza, TanzaniaMwanza Research Centre, National Institute for Medical Research, Mwanza, TanzaniaMwanza Research Centre, National Institute for Medical Research, Mwanza, TanzaniaDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, DenmarkDepartment of Population Health, London School of Hygiene and Tropical Medicine, London, United KingdomCentre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, DenmarkDepartment of Infectious Diseases, Copenhagen University Hospital, Copenhagen, DenmarkMedical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United KingdomDepartment of Infectious Diseases, Rigshospitalet, Copenhagen, DenmarkDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, DenmarkDepartment of Infectious Diseases, Rigshospitalet, Copenhagen, DenmarkMwanza Research Centre, National Institute for Medical Research, Mwanza, TanzaniaIntroductionResearch on the associations of physical activity and cardiorespiratory fitness with β-cell dysfunction and insulin resistance among adults in Sub-Saharan Africa (SSA) is limited. We assessed the association of physical activity and cardiorespiratory fitness with β-cell function, insulin resistance and diabetes among people living with HIV (PLWH) ART-naïve and HIV-uninfected Tanzanian adults.MethodIn a cross-sectional study, we collected data on socio-demography, anthropometry, fat mass and fat free mass and C-reactive protein. Data on glucose and insulin collected during an oral glucose tolerance test were used to assess β-cell dysfunction (defined as insulinogenic index <0.71 (mU/L)/(mmol/L), HOMA-β index <38.3 (mU/L)/(mmol/L), and overall insulin release index <33.3 (mU/L)/(mmol/L)), oral disposition index <0.16 (mU/L)/(mg/dL)(mU/L)-1, insulin resistance (HOMA-IR index >1.9 (mU/L)/(mmol/L) and Matsuda index <7.2 (mU/L)/(mmol/L), prediabetes and diabetes which were the dependent variables. Physical activity energy expenditure (PAEE), sleeping heart rate (SHR), and maximum uptake of oxygen during exercise (VO2 max) were the independent variables and were assessed using a combined heart rate and accelerometer monitor. Logistic regressions were used to assess the associations.ResultsOf 391 participants, 272 were PLWH and 119 HIV-uninfected. The mean age was 39 ( ± 10.5) years and 60% (n=235) were females. Compared to lower tertile, middle tertile of PAEE was associated with lower odds of abnormal insulinogenic index (OR=0.48, 95%CI: 0.27, 0.82). A 5 kj/kg/day increment of PAEE was associated with lower odds of abnormal HOMA-IR (OR=0.91, 95%CI: 0.84, 0.98), and reduced risk of pre-diabetes (RRR=0.98, 95%CI: 0.96, 0.99) and diabetes (RRR=0.92, 95%CI: 0.88, 0.96). An increment of 5 beats per min of SHR was associated with higher risk of diabetes (RRR=1.06, 95%CI: 1.01, 1.11). An increase of 5 mLO2/kg/min of VO2 max was associated with lower risk of pre-diabetes (RRR=0.91, 95%CI: 0.86, 0.97), but not diabetes. HIV status did not modify any of these associations (interaction, p>0.05).ConclusionAmong Tanzanian adults PLWH and HIV-uninfected individuals, low physical activity was associated with β-cell dysfunction, insulin resistance and diabetes. Research is needed to assess if physical activity interventions can improve β-cell function and insulin sensitivity to reduce risk of diabetes and delay progression of diabetes in SSA.https://www.frontiersin.org/articles/10.3389/fendo.2022.885988/fullphysical activity energy expendituresleeping heart rateVO2maxinsulinogenic indexHOMA-βoverall insulin release |
| spellingShingle | Brenda Kitilya Robert Peck Robert Peck Robert Peck John Changalucha Kidola Jeremiah Bazil B. Kavishe Henrik Friis Suzanne Filteau Rikke Krogh-Madsen Rikke Krogh-Madsen Soren Brage Daniel Faurholt-Jepsen Mette F. Olsen Mette F. Olsen George PrayGod The association of physical activity and cardiorespiratory fitness with β-cell dysfunction, insulin resistance, and diabetes among adults in north-western Tanzania: A cross-sectional study Frontiers in Endocrinology physical activity energy expenditure sleeping heart rate VO2max insulinogenic index HOMA-β overall insulin release |
| title | The association of physical activity and cardiorespiratory fitness with β-cell dysfunction, insulin resistance, and diabetes among adults in north-western Tanzania: A cross-sectional study |
| title_full | The association of physical activity and cardiorespiratory fitness with β-cell dysfunction, insulin resistance, and diabetes among adults in north-western Tanzania: A cross-sectional study |
| title_fullStr | The association of physical activity and cardiorespiratory fitness with β-cell dysfunction, insulin resistance, and diabetes among adults in north-western Tanzania: A cross-sectional study |
| title_full_unstemmed | The association of physical activity and cardiorespiratory fitness with β-cell dysfunction, insulin resistance, and diabetes among adults in north-western Tanzania: A cross-sectional study |
| title_short | The association of physical activity and cardiorespiratory fitness with β-cell dysfunction, insulin resistance, and diabetes among adults in north-western Tanzania: A cross-sectional study |
| title_sort | association of physical activity and cardiorespiratory fitness with β cell dysfunction insulin resistance and diabetes among adults in north western tanzania a cross sectional study |
| topic | physical activity energy expenditure sleeping heart rate VO2max insulinogenic index HOMA-β overall insulin release |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.885988/full |
| work_keys_str_mv | AT brendakitilya theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT robertpeck theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT robertpeck theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT robertpeck theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT johnchangalucha theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT kidolajeremiah theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT bazilbkavishe theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT henrikfriis theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT suzannefilteau theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT rikkekroghmadsen theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT rikkekroghmadsen theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT sorenbrage theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT danielfaurholtjepsen theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT mettefolsen theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT mettefolsen theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT georgepraygod theassociationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT brendakitilya associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT robertpeck associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT robertpeck associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT robertpeck associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT johnchangalucha associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT kidolajeremiah associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT bazilbkavishe associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT henrikfriis associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT suzannefilteau associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT rikkekroghmadsen associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT rikkekroghmadsen associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT sorenbrage associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT danielfaurholtjepsen associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT mettefolsen associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT mettefolsen associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy AT georgepraygod associationofphysicalactivityandcardiorespiratoryfitnesswithbcelldysfunctioninsulinresistanceanddiabetesamongadultsinnorthwesterntanzaniaacrosssectionalstudy |