Clinical Characteristics of Elderly Patients with Refractory Gastroesophageal Reflux Disease
Background: Gastroesophageal reflux disease (GERD) is a common upper gastrointestinal disease, and almost 30% of GERD patients do not respond well to proton pump inhibitor (PPI) therapy. The aim of this study is to evaluate the clinical characteristics of elderly GERD patients who either respond to...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taiwan Society of Geriatric Emergency and Critical Medicine (TSGECM)
2016-06-01
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| Series: | International Journal of Gerontology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873959816300400 |
| _version_ | 1818925259354537984 |
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| author | Ying-Nan Li Xiao-Ning Zhao Ting-Ting Li Chang-Zheng Wang Wei-Hua Wang Lei Tian Ben-Yan Wu |
| author_facet | Ying-Nan Li Xiao-Ning Zhao Ting-Ting Li Chang-Zheng Wang Wei-Hua Wang Lei Tian Ben-Yan Wu |
| author_sort | Ying-Nan Li |
| collection | DOAJ |
| description | Background: Gastroesophageal reflux disease (GERD) is a common upper gastrointestinal disease, and almost 30% of GERD patients do not respond well to proton pump inhibitor (PPI) therapy. The aim of this study is to evaluate the clinical characteristics of elderly GERD patients who either respond to or resist PPI therapy.
Methods: A total of 198 patients (75.9 ± 6.4 years, 73.7% males) with GERD receiving PPI treatment were enrolled in this study. Enrolled patients were requested to complete a questionnaire and a personal interview concerning their demographics, comorbidities, symptoms, and endoscopic findings.
Results: Among the 198 enrolled patients, 135 responded to PPI once or twice daily (Group R), while 63 failed to respond to PPI twice daily (Group F). Cross-group differences were detected for body mass index (p = 0.042), family status (p = 0.028), depression (0.7% vs. 7.9%, p = 0.03), compliance (77% vs. 60%, p = 0.015), and hiatal hernia (6.7% vs. 17.5%, p = 0.019).
Conclusion: PPI failure appears to be significantly influenced by body mass index, family status, depression, compliance, and hiatal hernia of GERD patients. |
| first_indexed | 2024-12-20T02:38:23Z |
| format | Article |
| id | doaj.art-9ef80e206ba8428daa8f982a887f1300 |
| institution | Directory Open Access Journal |
| issn | 1873-9598 |
| language | English |
| last_indexed | 2024-12-20T02:38:23Z |
| publishDate | 2016-06-01 |
| publisher | Taiwan Society of Geriatric Emergency and Critical Medicine (TSGECM) |
| record_format | Article |
| series | International Journal of Gerontology |
| spelling | doaj.art-9ef80e206ba8428daa8f982a887f13002022-12-21T19:56:22ZengTaiwan Society of Geriatric Emergency and Critical Medicine (TSGECM)International Journal of Gerontology1873-95982016-06-0110210010410.1016/j.ijge.2015.03.003Clinical Characteristics of Elderly Patients with Refractory Gastroesophageal Reflux DiseaseYing-Nan Li0Xiao-Ning Zhao1Ting-Ting Li2Chang-Zheng Wang3Wei-Hua Wang4Lei Tian5Ben-Yan Wu6Department of Geriatric Gastroenterology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Geriatric Gastroenterology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Geriatric Gastroenterology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Geriatric Gastroenterology, Chinese PLA General Hospital, Beijing, ChinaInstitute of Geriatrics and Gerontology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Geriatric Gastroenterology, Chinese PLA General Hospital, Beijing, ChinaBackground: Gastroesophageal reflux disease (GERD) is a common upper gastrointestinal disease, and almost 30% of GERD patients do not respond well to proton pump inhibitor (PPI) therapy. The aim of this study is to evaluate the clinical characteristics of elderly GERD patients who either respond to or resist PPI therapy. Methods: A total of 198 patients (75.9 ± 6.4 years, 73.7% males) with GERD receiving PPI treatment were enrolled in this study. Enrolled patients were requested to complete a questionnaire and a personal interview concerning their demographics, comorbidities, symptoms, and endoscopic findings. Results: Among the 198 enrolled patients, 135 responded to PPI once or twice daily (Group R), while 63 failed to respond to PPI twice daily (Group F). Cross-group differences were detected for body mass index (p = 0.042), family status (p = 0.028), depression (0.7% vs. 7.9%, p = 0.03), compliance (77% vs. 60%, p = 0.015), and hiatal hernia (6.7% vs. 17.5%, p = 0.019). Conclusion: PPI failure appears to be significantly influenced by body mass index, family status, depression, compliance, and hiatal hernia of GERD patients.http://www.sciencedirect.com/science/article/pii/S1873959816300400gastroesophageal reflux diseasegeriatricshuman characteristicsproton pump inhibitors |
| spellingShingle | Ying-Nan Li Xiao-Ning Zhao Ting-Ting Li Chang-Zheng Wang Wei-Hua Wang Lei Tian Ben-Yan Wu Clinical Characteristics of Elderly Patients with Refractory Gastroesophageal Reflux Disease International Journal of Gerontology gastroesophageal reflux disease geriatrics human characteristics proton pump inhibitors |
| title | Clinical Characteristics of Elderly Patients with Refractory Gastroesophageal Reflux Disease |
| title_full | Clinical Characteristics of Elderly Patients with Refractory Gastroesophageal Reflux Disease |
| title_fullStr | Clinical Characteristics of Elderly Patients with Refractory Gastroesophageal Reflux Disease |
| title_full_unstemmed | Clinical Characteristics of Elderly Patients with Refractory Gastroesophageal Reflux Disease |
| title_short | Clinical Characteristics of Elderly Patients with Refractory Gastroesophageal Reflux Disease |
| title_sort | clinical characteristics of elderly patients with refractory gastroesophageal reflux disease |
| topic | gastroesophageal reflux disease geriatrics human characteristics proton pump inhibitors |
| url | http://www.sciencedirect.com/science/article/pii/S1873959816300400 |
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