Impact of milk secretor status on the fecal metabolome and microbiota of breastfed infants
ABSTRACTMaternal secretor status has been shown to be associated with the presence of specific fucosylated human milk oligosaccharides (HMOs), and the impact of maternal secretor status on infant gut microbiota measured through 16s sequencing has previously been reported. None of those studies have...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2257273 |
| _version_ | 1797320571000717312 |
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| author | Aidong Wang Aly Diana Sofa Rahmannia Rosalind S Gibson Lisa A Houghton Carolyn M Slupsky |
| author_facet | Aidong Wang Aly Diana Sofa Rahmannia Rosalind S Gibson Lisa A Houghton Carolyn M Slupsky |
| author_sort | Aidong Wang |
| collection | DOAJ |
| description | ABSTRACTMaternal secretor status has been shown to be associated with the presence of specific fucosylated human milk oligosaccharides (HMOs), and the impact of maternal secretor status on infant gut microbiota measured through 16s sequencing has previously been reported. None of those studies have confirmed exclusive breastfeeding nor investigated the impact of maternal secretor status on gut microbial fermentation products. The present study focused on exclusively breastfed (EBF) Indonesian infants, with exclusive breastfeeding validated through the stable isotope deuterium oxide dose-to-mother (DTM) technique, and the impact of maternal secretor status on the infant fecal microbiome and metabolome. Maternal secretor status did not alter the within-community (alpha) diversity, between-community (beta) diversity, or the relative abundance of bacterial taxa at the genus level. However, infants fed milk from secretor (Se+) mothers exhibited a lower level of fecal succinate, amino acids and their derivatives, and a higher level of 1,2-propanediol when compared to infants fed milk from non-secretor (Se-) mothers. Interestingly, for infants consuming milk from Se+ mothers, there was a correlation between the relative abundance of Bifidobacterium and Streptococcus, and between each of these genera and fecal metabolites that was not observed in infants receiving milk from Se- mothers. Our findings indicate that the secretor status of the mother impacts the gut microbiome of the exclusively breastfed infant. |
| first_indexed | 2024-03-08T04:41:06Z |
| format | Article |
| id | doaj.art-9ef9cd7ec3084d57b5a047195eed8e09 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-03-08T04:41:06Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-9ef9cd7ec3084d57b5a047195eed8e092024-02-08T12:02:07ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115210.1080/19490976.2023.2257273Impact of milk secretor status on the fecal metabolome and microbiota of breastfed infantsAidong Wang0Aly Diana1Sofa Rahmannia2Rosalind S Gibson3Lisa A Houghton4Carolyn M Slupsky5Department of Food Science and Technology, University of California, Davis, CA, USADepartment of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, IndonesiaFaculty of Medicine, Universitas Pasundan, Bandung, IndonesiaDepartment of Human Nutrition, University of Otago, Dunedin, New ZealandDepartment of Human Nutrition, University of Otago, Dunedin, New ZealandDepartment of Food Science and Technology, University of California, Davis, CA, USAABSTRACTMaternal secretor status has been shown to be associated with the presence of specific fucosylated human milk oligosaccharides (HMOs), and the impact of maternal secretor status on infant gut microbiota measured through 16s sequencing has previously been reported. None of those studies have confirmed exclusive breastfeeding nor investigated the impact of maternal secretor status on gut microbial fermentation products. The present study focused on exclusively breastfed (EBF) Indonesian infants, with exclusive breastfeeding validated through the stable isotope deuterium oxide dose-to-mother (DTM) technique, and the impact of maternal secretor status on the infant fecal microbiome and metabolome. Maternal secretor status did not alter the within-community (alpha) diversity, between-community (beta) diversity, or the relative abundance of bacterial taxa at the genus level. However, infants fed milk from secretor (Se+) mothers exhibited a lower level of fecal succinate, amino acids and their derivatives, and a higher level of 1,2-propanediol when compared to infants fed milk from non-secretor (Se-) mothers. Interestingly, for infants consuming milk from Se+ mothers, there was a correlation between the relative abundance of Bifidobacterium and Streptococcus, and between each of these genera and fecal metabolites that was not observed in infants receiving milk from Se- mothers. Our findings indicate that the secretor status of the mother impacts the gut microbiome of the exclusively breastfed infant.https://www.tandfonline.com/doi/10.1080/19490976.2023.2257273Breast milksecretor statusoligosaccharidesexclusive breastfeedinginfantmicrobial metabolism |
| spellingShingle | Aidong Wang Aly Diana Sofa Rahmannia Rosalind S Gibson Lisa A Houghton Carolyn M Slupsky Impact of milk secretor status on the fecal metabolome and microbiota of breastfed infants Gut Microbes Breast milk secretor status oligosaccharides exclusive breastfeeding infant microbial metabolism |
| title | Impact of milk secretor status on the fecal metabolome and microbiota of breastfed infants |
| title_full | Impact of milk secretor status on the fecal metabolome and microbiota of breastfed infants |
| title_fullStr | Impact of milk secretor status on the fecal metabolome and microbiota of breastfed infants |
| title_full_unstemmed | Impact of milk secretor status on the fecal metabolome and microbiota of breastfed infants |
| title_short | Impact of milk secretor status on the fecal metabolome and microbiota of breastfed infants |
| title_sort | impact of milk secretor status on the fecal metabolome and microbiota of breastfed infants |
| topic | Breast milk secretor status oligosaccharides exclusive breastfeeding infant microbial metabolism |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2257273 |
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