Newly Developed Self-Assembling Antioxidants as Potential Therapeutics for the Cancers
Elevated reactive oxygen species (ROS) have been implicated as significant for cancer survival by functioning as oncogene activators and secondary messengers. Hence, the attenuation of ROS-signaling pathways in cancer by antioxidants seems a suitable therapeutic regime for targeting cancers. Low mol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/2/92 |
| _version_ | 1797416532345618432 |
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| author | Babita Shashni Yukio Nagasaki |
| author_facet | Babita Shashni Yukio Nagasaki |
| author_sort | Babita Shashni |
| collection | DOAJ |
| description | Elevated reactive oxygen species (ROS) have been implicated as significant for cancer survival by functioning as oncogene activators and secondary messengers. Hence, the attenuation of ROS-signaling pathways in cancer by antioxidants seems a suitable therapeutic regime for targeting cancers. Low molecular weight (LMW) antioxidants such as 2,2,6,6-tetramethylpyperidine-1-oxyl (TEMPO), although they are catalytically effective in vitro, exerts off-target effects in vivo due to their size, thus, limiting their clinical use. Here, we discuss the superior impacts of our TEMPO radical-conjugated self-assembling antioxidant nanoparticle (RNP) compared to the LMW counterpart in terms of pharmacokinetics, therapeutic effect, and adverse effects in various cancer models. |
| first_indexed | 2024-03-09T06:05:35Z |
| format | Article |
| id | doaj.art-9efa1c5e5acb4a27aa6972a0a486d4dc |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T06:05:35Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-9efa1c5e5acb4a27aa6972a0a486d4dc2023-12-03T12:05:03ZengMDPI AGJournal of Personalized Medicine2075-44262021-02-011129210.3390/jpm11020092Newly Developed Self-Assembling Antioxidants as Potential Therapeutics for the CancersBabita Shashni0Yukio Nagasaki1Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki 305-8573, JapanDepartment of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki 305-8573, JapanElevated reactive oxygen species (ROS) have been implicated as significant for cancer survival by functioning as oncogene activators and secondary messengers. Hence, the attenuation of ROS-signaling pathways in cancer by antioxidants seems a suitable therapeutic regime for targeting cancers. Low molecular weight (LMW) antioxidants such as 2,2,6,6-tetramethylpyperidine-1-oxyl (TEMPO), although they are catalytically effective in vitro, exerts off-target effects in vivo due to their size, thus, limiting their clinical use. Here, we discuss the superior impacts of our TEMPO radical-conjugated self-assembling antioxidant nanoparticle (RNP) compared to the LMW counterpart in terms of pharmacokinetics, therapeutic effect, and adverse effects in various cancer models.https://www.mdpi.com/2075-4426/11/2/92cancerreactive oxygen speciesantioxidantself-assembling drug |
| spellingShingle | Babita Shashni Yukio Nagasaki Newly Developed Self-Assembling Antioxidants as Potential Therapeutics for the Cancers Journal of Personalized Medicine cancer reactive oxygen species antioxidant self-assembling drug |
| title | Newly Developed Self-Assembling Antioxidants as Potential Therapeutics for the Cancers |
| title_full | Newly Developed Self-Assembling Antioxidants as Potential Therapeutics for the Cancers |
| title_fullStr | Newly Developed Self-Assembling Antioxidants as Potential Therapeutics for the Cancers |
| title_full_unstemmed | Newly Developed Self-Assembling Antioxidants as Potential Therapeutics for the Cancers |
| title_short | Newly Developed Self-Assembling Antioxidants as Potential Therapeutics for the Cancers |
| title_sort | newly developed self assembling antioxidants as potential therapeutics for the cancers |
| topic | cancer reactive oxygen species antioxidant self-assembling drug |
| url | https://www.mdpi.com/2075-4426/11/2/92 |
| work_keys_str_mv | AT babitashashni newlydevelopedselfassemblingantioxidantsaspotentialtherapeuticsforthecancers AT yukionagasaki newlydevelopedselfassemblingantioxidantsaspotentialtherapeuticsforthecancers |