Intracellular acidity impedes KCa3.1 activation by Riluzole and SKA-31

Intracellular acidity impedes KCa3.1 activation by Riluzole and SKA-31

Background:The unique microenvironment in tumors inhibits the normal functioning of tumor-infiltrating lymphocytes, leading to immune evasion and cancer progression. Over-activation of KCa3.1 using positive modulators has been proposed to rescue the anti-tumor response. One of the key characteristic...

Full description

Bibliographic Details
Main Authors: Marco Cozzolino, Gyorgy Panyi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Pharmacology
Subjects:
ion channels
KCa3.1
Riluzole
SKA-31
acidity
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1380655/full

Similar Items

Similar Items