A third generation regimen VACOP-B with or without adjuvant radiotherapy for aggressive localized non-Hodgkin's lymphoma: report from the Italian Non-Hodgkin's Lymphoma Co-operative Study Group
The objective of this multicenter prospective study was to determine the clinical efficacy and toxicity of a polychemotherapeutic third generation regimen, VACOP-B, with or without radiotherapy as front-line therapy in aggressive localized non-Hodgkin's lymphoma. Ninety-three adult patients (47...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2004-05-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500014 |
| _version_ | 1828855923046612992 |
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| author | G. Santini C. De Souza S. Aversa C. Patti L. Tedeschi M. Candela A. Olivieri T. Chisesi A. Rubagotti R. Centurioni V. Nardi M. Congiu M. Gennaro M. Truini |
| author_facet | G. Santini C. De Souza S. Aversa C. Patti L. Tedeschi M. Candela A. Olivieri T. Chisesi A. Rubagotti R. Centurioni V. Nardi M. Congiu M. Gennaro M. Truini |
| author_sort | G. Santini |
| collection | DOAJ |
| description | The objective of this multicenter prospective study was to determine the clinical efficacy and toxicity of a polychemotherapeutic third generation regimen, VACOP-B, with or without radiotherapy as front-line therapy in aggressive localized non-Hodgkin's lymphoma. Ninety-three adult patients (47 males and 46 females, median age 45 years) with aggressive localized non-Hodgkin's lymphoma, 43 in stage I and 50 in stage II (non-bulky), were included in the study. Stage I patients received VACOP-B for 6 weeks plus involved field radiotherapy and stage II patients received 12 weeks VACOP-B plus involved field radiotherapy on residual masses. Eighty-six (92.5%) achieved complete remission and 4 (4.3%) partial remission. Three patients (3.2%) were primarily resistant. Ten-year probability of survival, progression-free survival and disease-free survival were 87.3, 79.9 and 83.9%, respectively. Eighty-four patients are surviving at a median observation time of 57 months (range: 6-126). Statistical analysis showed no difference between stages I and II in terms of response, ten-year probability of survival, progression-free survival or disease-free survival. Side effects and toxicity were negligible and were similar in the two patient groups. The results of this prospective study suggest that 6 weeks of VACOP-B treatment plus radiotherapy may be the therapy of choice in stage I aggressive non-Hodgkin's lymphoma. Twelve weeks of VACOP-B treatment with or without radiotherapy was shown to be effective and feasible for stage II. These observations need to be confirmed by a phase III study comparing first and third generation protocols in stage I-II aggressive non-Hodgkin's lymphoma. |
| first_indexed | 2024-12-13T01:03:47Z |
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| id | doaj.art-9efaa5000afe4941bb7930d225af2a80 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-13T01:03:47Z |
| publishDate | 2004-05-01 |
| publisher | Associação Brasileira de Divulgação Científica |
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| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-9efaa5000afe4941bb7930d225af2a802022-12-22T00:04:37ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2004-05-0137571972810.1590/S0100-879X2004000500014A third generation regimen VACOP-B with or without adjuvant radiotherapy for aggressive localized non-Hodgkin's lymphoma: report from the Italian Non-Hodgkin's Lymphoma Co-operative Study GroupG. SantiniC. De SouzaS. AversaC. PattiL. TedeschiM. CandelaA. OlivieriT. ChisesiA. RubagottiR. CenturioniV. NardiM. CongiuM. GennaroM. TruiniThe objective of this multicenter prospective study was to determine the clinical efficacy and toxicity of a polychemotherapeutic third generation regimen, VACOP-B, with or without radiotherapy as front-line therapy in aggressive localized non-Hodgkin's lymphoma. Ninety-three adult patients (47 males and 46 females, median age 45 years) with aggressive localized non-Hodgkin's lymphoma, 43 in stage I and 50 in stage II (non-bulky), were included in the study. Stage I patients received VACOP-B for 6 weeks plus involved field radiotherapy and stage II patients received 12 weeks VACOP-B plus involved field radiotherapy on residual masses. Eighty-six (92.5%) achieved complete remission and 4 (4.3%) partial remission. Three patients (3.2%) were primarily resistant. Ten-year probability of survival, progression-free survival and disease-free survival were 87.3, 79.9 and 83.9%, respectively. Eighty-four patients are surviving at a median observation time of 57 months (range: 6-126). Statistical analysis showed no difference between stages I and II in terms of response, ten-year probability of survival, progression-free survival or disease-free survival. Side effects and toxicity were negligible and were similar in the two patient groups. The results of this prospective study suggest that 6 weeks of VACOP-B treatment plus radiotherapy may be the therapy of choice in stage I aggressive non-Hodgkin's lymphoma. Twelve weeks of VACOP-B treatment with or without radiotherapy was shown to be effective and feasible for stage II. These observations need to be confirmed by a phase III study comparing first and third generation protocols in stage I-II aggressive non-Hodgkin's lymphoma.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500014Localized aggressive non-Hodgkin's lymphomaVACOP-BRadiotherapyToxicity |
| spellingShingle | G. Santini C. De Souza S. Aversa C. Patti L. Tedeschi M. Candela A. Olivieri T. Chisesi A. Rubagotti R. Centurioni V. Nardi M. Congiu M. Gennaro M. Truini A third generation regimen VACOP-B with or without adjuvant radiotherapy for aggressive localized non-Hodgkin's lymphoma: report from the Italian Non-Hodgkin's Lymphoma Co-operative Study Group Brazilian Journal of Medical and Biological Research Localized aggressive non-Hodgkin's lymphoma VACOP-B Radiotherapy Toxicity |
| title | A third generation regimen VACOP-B with or without adjuvant radiotherapy for aggressive localized non-Hodgkin's lymphoma: report from the Italian Non-Hodgkin's Lymphoma Co-operative Study Group |
| title_full | A third generation regimen VACOP-B with or without adjuvant radiotherapy for aggressive localized non-Hodgkin's lymphoma: report from the Italian Non-Hodgkin's Lymphoma Co-operative Study Group |
| title_fullStr | A third generation regimen VACOP-B with or without adjuvant radiotherapy for aggressive localized non-Hodgkin's lymphoma: report from the Italian Non-Hodgkin's Lymphoma Co-operative Study Group |
| title_full_unstemmed | A third generation regimen VACOP-B with or without adjuvant radiotherapy for aggressive localized non-Hodgkin's lymphoma: report from the Italian Non-Hodgkin's Lymphoma Co-operative Study Group |
| title_short | A third generation regimen VACOP-B with or without adjuvant radiotherapy for aggressive localized non-Hodgkin's lymphoma: report from the Italian Non-Hodgkin's Lymphoma Co-operative Study Group |
| title_sort | third generation regimen vacop b with or without adjuvant radiotherapy for aggressive localized non hodgkin s lymphoma report from the italian non hodgkin s lymphoma co operative study group |
| topic | Localized aggressive non-Hodgkin's lymphoma VACOP-B Radiotherapy Toxicity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500014 |
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