Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways

Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways

Abstract Background TRAIL, tumor necrosis factor-related apoptosis-inducing ligand, can selectively kill cancer cells with little or no cytotoxicity toward normal human cells and is regarded as a potential relatively safe antitumor drug. However, some cancer cells are resistant to TRAIL-induced apop...

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Bibliographic Details
Main Authors: Zhi Lan Guo, Jing Zhe Li, Yan Yan Ma, Dan Qian, Ju Ying Zhong, Meng Meng Jin, Peng Huang, Lu Yang Che, Bing Pan, Yi Wang, Zhen Xiao Sun, Chang Zhen Liu
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Cell Biology
Subjects:
Shikonin
TRAIL
Resistant cancers
Sensitization
Online Access:http://link.springer.com/article/10.1186/s12860-018-0179-7

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