Importance of Autophagy in Mediating Cellular Responses to Iron Overload in Cardiomyocytes
Both iron overload and deficiency can promote development of cardiomyopathy. Advances in our knowledge from recent research have indicated numerous potential cellular mechanisms. Regulation of myocardial autophagy by iron is of particular interest and will be reviewed here. Autophagy is already well...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2022-05-01
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| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/RCM/23/5/10.31083/j.rcm2305167 |
| _version_ | 1818470043818655744 |
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| author | Eddie Tam Chloe Reno Khang Nguyen Sungji Cho Gary Sweeney |
| author_facet | Eddie Tam Chloe Reno Khang Nguyen Sungji Cho Gary Sweeney |
| author_sort | Eddie Tam |
| collection | DOAJ |
| description | Both iron overload and deficiency can promote development of cardiomyopathy. Advances in our knowledge from recent research have indicated numerous potential cellular mechanisms. Regulation of myocardial autophagy by iron is of particular interest and will be reviewed here. Autophagy is already well established to play a significant role in regulating the development of heart failure. This review will focus on regulation of autophagy by iron, crosstalk between autophagy and other cellular process which have also already been implicated in heart failure (oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, ferroptosis) and the therapeutic potential of targeting these interactions. |
| first_indexed | 2024-04-13T21:32:34Z |
| format | Article |
| id | doaj.art-9efb8bd894d44dda8477b87797af876b |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-04-13T21:32:34Z |
| publishDate | 2022-05-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-9efb8bd894d44dda8477b87797af876b2022-12-22T02:29:07ZengIMR PressReviews in Cardiovascular Medicine1530-65502022-05-0123516710.31083/j.rcm2305167S1530-6550(22)00500-2Importance of Autophagy in Mediating Cellular Responses to Iron Overload in CardiomyocytesEddie Tam0Chloe Reno1Khang Nguyen2Sungji Cho3Gary Sweeney4Department of Biology, York University, Toronto, ON M3J 1P3, CanadaDepartment of Biology, York University, Toronto, ON M3J 1P3, CanadaDepartment of Biology, York University, Toronto, ON M3J 1P3, CanadaDepartment of Biology, York University, Toronto, ON M3J 1P3, CanadaDepartment of Biology, York University, Toronto, ON M3J 1P3, CanadaBoth iron overload and deficiency can promote development of cardiomyopathy. Advances in our knowledge from recent research have indicated numerous potential cellular mechanisms. Regulation of myocardial autophagy by iron is of particular interest and will be reviewed here. Autophagy is already well established to play a significant role in regulating the development of heart failure. This review will focus on regulation of autophagy by iron, crosstalk between autophagy and other cellular process which have also already been implicated in heart failure (oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, ferroptosis) and the therapeutic potential of targeting these interactions.https://www.imrpress.com/journal/RCM/23/5/10.31083/j.rcm2305167iron overloadautophagyadiponectinoxidative stressendoplasmic reticulum stressmitochondriaferroptosis |
| spellingShingle | Eddie Tam Chloe Reno Khang Nguyen Sungji Cho Gary Sweeney Importance of Autophagy in Mediating Cellular Responses to Iron Overload in Cardiomyocytes Reviews in Cardiovascular Medicine iron overload autophagy adiponectin oxidative stress endoplasmic reticulum stress mitochondria ferroptosis |
| title | Importance of Autophagy in Mediating Cellular Responses to Iron Overload in Cardiomyocytes |
| title_full | Importance of Autophagy in Mediating Cellular Responses to Iron Overload in Cardiomyocytes |
| title_fullStr | Importance of Autophagy in Mediating Cellular Responses to Iron Overload in Cardiomyocytes |
| title_full_unstemmed | Importance of Autophagy in Mediating Cellular Responses to Iron Overload in Cardiomyocytes |
| title_short | Importance of Autophagy in Mediating Cellular Responses to Iron Overload in Cardiomyocytes |
| title_sort | importance of autophagy in mediating cellular responses to iron overload in cardiomyocytes |
| topic | iron overload autophagy adiponectin oxidative stress endoplasmic reticulum stress mitochondria ferroptosis |
| url | https://www.imrpress.com/journal/RCM/23/5/10.31083/j.rcm2305167 |
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