Zika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference.
Experimental Zika virus infection in non-human primates results in acute viral load dynamics that can be well-described by mathematical models. The inoculum dose that would be received in a natural infection setting is likely lower than the experimental infections and how this difference affects the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1008564 |
| _version_ | 1819260246273556480 |
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| author | Katharine Best Dan H Barouch Jeremie Guedj Ruy M Ribeiro Alan S Perelson |
| author_facet | Katharine Best Dan H Barouch Jeremie Guedj Ruy M Ribeiro Alan S Perelson |
| author_sort | Katharine Best |
| collection | DOAJ |
| description | Experimental Zika virus infection in non-human primates results in acute viral load dynamics that can be well-described by mathematical models. The inoculum dose that would be received in a natural infection setting is likely lower than the experimental infections and how this difference affects the viral dynamics and immune response is unclear. Here we study a dataset of experimental infection of non-human primates with a range of doses of Zika virus. We develop new models of infection incorporating both an innate immune response and viral interference with that response. We find that such a model explains the data better than models with no interaction between virus and the immune response. We also find that larger inoculum doses lead to faster dynamics of infection, but approximately the same total amount of viral production. |
| first_indexed | 2024-12-23T19:22:51Z |
| format | Article |
| id | doaj.art-9efbc980c76a4fd9be6913b5e8777d2a |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-23T19:22:51Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-9efbc980c76a4fd9be6913b5e8777d2a2022-12-21T17:34:06ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582021-01-01171e100856410.1371/journal.pcbi.1008564Zika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference.Katharine BestDan H BarouchJeremie GuedjRuy M RibeiroAlan S PerelsonExperimental Zika virus infection in non-human primates results in acute viral load dynamics that can be well-described by mathematical models. The inoculum dose that would be received in a natural infection setting is likely lower than the experimental infections and how this difference affects the viral dynamics and immune response is unclear. Here we study a dataset of experimental infection of non-human primates with a range of doses of Zika virus. We develop new models of infection incorporating both an innate immune response and viral interference with that response. We find that such a model explains the data better than models with no interaction between virus and the immune response. We also find that larger inoculum doses lead to faster dynamics of infection, but approximately the same total amount of viral production.https://doi.org/10.1371/journal.pcbi.1008564 |
| spellingShingle | Katharine Best Dan H Barouch Jeremie Guedj Ruy M Ribeiro Alan S Perelson Zika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference. PLoS Computational Biology |
| title | Zika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference. |
| title_full | Zika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference. |
| title_fullStr | Zika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference. |
| title_full_unstemmed | Zika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference. |
| title_short | Zika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference. |
| title_sort | zika virus dynamics effects of inoculum dose the innate immune response and viral interference |
| url | https://doi.org/10.1371/journal.pcbi.1008564 |
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