Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia
Background: CD26 is expressed in all chronic myeloid leukemia (CML) patients. This study investigated the role of CD26+ LSCs in diagnosis and follow up of CML patients. Method: Flow cytometry was performed to evaluate CD26+ LSC in peripheral blood (PB) in CML patients. BCR-ABL1 transcript level meas...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Leukemia Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048922000334 |
| _version_ | 1817979308029771776 |
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| author | Huda F Ebian AL-Shabrawy M. Abdelnabi Abdallah S. Abdelazem Tarek Khamis Hebatallah M. Fawzy Samia Hussein |
| author_facet | Huda F Ebian AL-Shabrawy M. Abdelnabi Abdallah S. Abdelazem Tarek Khamis Hebatallah M. Fawzy Samia Hussein |
| author_sort | Huda F Ebian |
| collection | DOAJ |
| description | Background: CD26 is expressed in all chronic myeloid leukemia (CML) patients. This study investigated the role of CD26+ LSCs in diagnosis and follow up of CML patients. Method: Flow cytometry was performed to evaluate CD26+ LSC in peripheral blood (PB) in CML patients. BCR-ABL1 transcript level measurement was performed using standard qRT-PCR technique. Results: CD26+ LSCs were significantly correlated with BCR-ABL1 transcript level at diagnosis and after three months of treatment. CD26+ LSCs also were significantly associated with the risk score after 12 months of treatment. Conclusion: CD26+ LSCs can be a useful marker in diagnosis and follow up of patients with CML. |
| first_indexed | 2024-04-13T22:41:09Z |
| format | Article |
| id | doaj.art-9efbfc9ef7944a15b0c388f9498ab811 |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-04-13T22:41:09Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-9efbfc9ef7944a15b0c388f9498ab8112022-12-22T02:26:37ZengElsevierLeukemia Research Reports2213-04892022-01-0117100321Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemiaHuda F Ebian0AL-Shabrawy M. Abdelnabi1Abdallah S. Abdelazem2Tarek Khamis3Hebatallah M. Fawzy4Samia Hussein5Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, EgyptInternal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, EgyptMedical Biochemistry Department, Faculty of Medicine, Suez University, Suez, EgyptPharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, EgyptPublic Health and Community Medicine Department, Faculty of Medicine, Zagazig University Zagazig, EgyptMedical Biochemistry& Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt; Corresponding author.Background: CD26 is expressed in all chronic myeloid leukemia (CML) patients. This study investigated the role of CD26+ LSCs in diagnosis and follow up of CML patients. Method: Flow cytometry was performed to evaluate CD26+ LSC in peripheral blood (PB) in CML patients. BCR-ABL1 transcript level measurement was performed using standard qRT-PCR technique. Results: CD26+ LSCs were significantly correlated with BCR-ABL1 transcript level at diagnosis and after three months of treatment. CD26+ LSCs also were significantly associated with the risk score after 12 months of treatment. Conclusion: CD26+ LSCs can be a useful marker in diagnosis and follow up of patients with CML.http://www.sciencedirect.com/science/article/pii/S2213048922000334CP-CMLCD26LSCsTKI |
| spellingShingle | Huda F Ebian AL-Shabrawy M. Abdelnabi Abdallah S. Abdelazem Tarek Khamis Hebatallah M. Fawzy Samia Hussein Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia Leukemia Research Reports CP-CML CD26 LSCs TKI |
| title | Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia |
| title_full | Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia |
| title_fullStr | Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia |
| title_full_unstemmed | Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia |
| title_short | Peripheral blood CD26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia |
| title_sort | peripheral blood cd26 positive leukemic stem cells as a possible diagnostic and prognostic marker in chronic myeloid leukemia |
| topic | CP-CML CD26 LSCs TKI |
| url | http://www.sciencedirect.com/science/article/pii/S2213048922000334 |
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