Molecular Basis of Neuronal Autophagy in Ageing: Insights from <i>Caenorhabditis elegans</i>
Autophagy is an evolutionarily conserved degradation process maintaining cell homeostasis. Induction of autophagy is triggered as a response to a broad range of cellular stress conditions, such as nutrient deprivation, protein aggregation, organelle damage and pathogen invasion. Macroautophagy invol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/3/694 |
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| author | Georgios Konstantinidis Nektarios Tavernarakis |
| author_facet | Georgios Konstantinidis Nektarios Tavernarakis |
| author_sort | Georgios Konstantinidis |
| collection | DOAJ |
| description | Autophagy is an evolutionarily conserved degradation process maintaining cell homeostasis. Induction of autophagy is triggered as a response to a broad range of cellular stress conditions, such as nutrient deprivation, protein aggregation, organelle damage and pathogen invasion. Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane organelle referred to as the autophagosome with subsequent degradation of its contents upon delivery to lysosomes. Autophagy plays critical roles in development, maintenance and survival of distinct cell populations including neurons. Consequently, age-dependent decline in autophagy predisposes animals for age-related diseases including neurodegeneration and compromises healthspan and longevity. In this review, we summarize recent advances in our understanding of the role of neuronal autophagy in ageing, focusing on studies in the nematode <i>Caenorhabditis elegans</i>. |
| first_indexed | 2024-03-10T13:03:07Z |
| format | Article |
| id | doaj.art-9efc352a898247f7ba60d64c5519f344 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T13:03:07Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9efc352a898247f7ba60d64c5519f3442023-11-21T11:21:56ZengMDPI AGCells2073-44092021-03-0110369410.3390/cells10030694Molecular Basis of Neuronal Autophagy in Ageing: Insights from <i>Caenorhabditis elegans</i>Georgios Konstantinidis0Nektarios Tavernarakis1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 70013 Heraklion, GreeceInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 70013 Heraklion, GreeceAutophagy is an evolutionarily conserved degradation process maintaining cell homeostasis. Induction of autophagy is triggered as a response to a broad range of cellular stress conditions, such as nutrient deprivation, protein aggregation, organelle damage and pathogen invasion. Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane organelle referred to as the autophagosome with subsequent degradation of its contents upon delivery to lysosomes. Autophagy plays critical roles in development, maintenance and survival of distinct cell populations including neurons. Consequently, age-dependent decline in autophagy predisposes animals for age-related diseases including neurodegeneration and compromises healthspan and longevity. In this review, we summarize recent advances in our understanding of the role of neuronal autophagy in ageing, focusing on studies in the nematode <i>Caenorhabditis elegans</i>.https://www.mdpi.com/2073-4409/10/3/694ageingautophagy<i>Caenorhabditis elegans</i>neurodegenerationmacroautophagyneuronal autophagy |
| spellingShingle | Georgios Konstantinidis Nektarios Tavernarakis Molecular Basis of Neuronal Autophagy in Ageing: Insights from <i>Caenorhabditis elegans</i> Cells ageing autophagy <i>Caenorhabditis elegans</i> neurodegeneration macroautophagy neuronal autophagy |
| title | Molecular Basis of Neuronal Autophagy in Ageing: Insights from <i>Caenorhabditis elegans</i> |
| title_full | Molecular Basis of Neuronal Autophagy in Ageing: Insights from <i>Caenorhabditis elegans</i> |
| title_fullStr | Molecular Basis of Neuronal Autophagy in Ageing: Insights from <i>Caenorhabditis elegans</i> |
| title_full_unstemmed | Molecular Basis of Neuronal Autophagy in Ageing: Insights from <i>Caenorhabditis elegans</i> |
| title_short | Molecular Basis of Neuronal Autophagy in Ageing: Insights from <i>Caenorhabditis elegans</i> |
| title_sort | molecular basis of neuronal autophagy in ageing insights from i caenorhabditis elegans i |
| topic | ageing autophagy <i>Caenorhabditis elegans</i> neurodegeneration macroautophagy neuronal autophagy |
| url | https://www.mdpi.com/2073-4409/10/3/694 |
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