Progress of temozolomide in the treatment of recurrent high-grade gliomas
<p>High-grade gliomas are central nervous system malignancies which are difficult to treat. Surgery, temozolomide combined with radiotherapy postoperatively and adjuvant chemotherapy with temozolomide have been established as the standard treatment options for high-grade gliomas. Nevertheless,...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tianjin Huanhu Hospital
2013-12-01
|
| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/866 |
| _version_ | 1811327382272868352 |
|---|---|
| author | Jin-duo LI Rong JIANG Jin-huan WANG Bin WANG Chun-hua MA Li-wei SUN Yuan LÜ Guo-fang HOU |
| author_facet | Jin-duo LI Rong JIANG Jin-huan WANG Bin WANG Chun-hua MA Li-wei SUN Yuan LÜ Guo-fang HOU |
| author_sort | Jin-duo LI |
| collection | DOAJ |
| description | <p>High-grade gliomas are central nervous system malignancies which are difficult to treat. Surgery, temozolomide combined with radiotherapy postoperatively and adjuvant chemotherapy with temozolomide have been established as the standard treatment options for high-grade gliomas. Nevertheless, the prognosis of patients with high-grade gliomas remains poor. At present, there is no standard therapy for recurrent or relapsed high-grade gliomas. Temozolomide is still an effective drug for the treatment of recurrent high-grade gliomas. According to the characteristics of patients, there have been many kinds of temozolomide administration and other treatments in combination. Individual therapy were paid more attention, so that the patients with high-grade gliomas recurrence could get greater survival benefit. This paper aims to introduce the progress of temozolomide in the treatment of recurrent high-grade gliomas in recent years.</p><p> </p><p>doi：10.3969/j.issn.1672-6731.2013.12.012</p> |
| first_indexed | 2024-04-13T15:05:44Z |
| format | Article |
| id | doaj.art-9efd250689c947e7867004c93ce6c468 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-04-13T15:05:44Z |
| publishDate | 2013-12-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-9efd250689c947e7867004c93ce6c4682022-12-22T02:42:10ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312013-12-01131210371043865Progress of temozolomide in the treatment of recurrent high-grade gliomasJin-duo LI0Rong JIANG1Jin-huan WANG2Bin WANG3Chun-hua MA4Li-wei SUN5Yuan LÜ6Guo-fang HOU7Department of Tumor Intervention, Tianjin Huanhu Hospital, Tianjin Cerebral Vascular and Neurodegenerative Diseases Key Laboratory, Tianjin Huanhu Hospital, Tianjin 300060, ChinaDepartment of Tumor Intervention, Tianjin Huanhu Hospital, Tianjin Cerebral Vascular and Neurodegenerative Diseases Key Laboratory, Tianjin Huanhu Hospital, Tianjin 300060, ChinaDepartment of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300060, ChinaDepartment of Tumor Intervention, Tianjin Huanhu Hospital, Tianjin Cerebral Vascular and Neurodegenerative Diseases Key Laboratory, Tianjin Huanhu Hospital, Tianjin 300060, ChinaDepartment of Tumor Intervention, Tianjin Huanhu Hospital, Tianjin Cerebral Vascular and Neurodegenerative Diseases Key Laboratory, Tianjin Huanhu Hospital, Tianjin 300060, ChinaDepartment of Tumor Intervention, Tianjin Huanhu Hospital, Tianjin Cerebral Vascular and Neurodegenerative Diseases Key Laboratory, Tianjin Huanhu Hospital, Tianjin 300060, ChinaDepartment of Tumor Intervention, Tianjin Huanhu Hospital, Tianjin Cerebral Vascular and Neurodegenerative Diseases Key Laboratory, Tianjin Huanhu Hospital, Tianjin 300060, ChinaDepartment of Tumor Intervention, Tianjin Huanhu Hospital, Tianjin Cerebral Vascular and Neurodegenerative Diseases Key Laboratory, Tianjin Huanhu Hospital, Tianjin 300060, China<p>High-grade gliomas are central nervous system malignancies which are difficult to treat. Surgery, temozolomide combined with radiotherapy postoperatively and adjuvant chemotherapy with temozolomide have been established as the standard treatment options for high-grade gliomas. Nevertheless, the prognosis of patients with high-grade gliomas remains poor. At present, there is no standard therapy for recurrent or relapsed high-grade gliomas. Temozolomide is still an effective drug for the treatment of recurrent high-grade gliomas. According to the characteristics of patients, there have been many kinds of temozolomide administration and other treatments in combination. Individual therapy were paid more attention, so that the patients with high-grade gliomas recurrence could get greater survival benefit. This paper aims to introduce the progress of temozolomide in the treatment of recurrent high-grade gliomas in recent years.</p><p> </p><p>doi：10.3969/j.issn.1672-6731.2013.12.012</p>http://www.cjcnn.org/index.php/cjcnn/article/view/866GliomaNeoplasm recurrence, localTemozolomide (not in MeSH)Review |
| spellingShingle | Jin-duo LI Rong JIANG Jin-huan WANG Bin WANG Chun-hua MA Li-wei SUN Yuan LÜ Guo-fang HOU Progress of temozolomide in the treatment of recurrent high-grade gliomas Chinese Journal of Contemporary Neurology and Neurosurgery Glioma Neoplasm recurrence, local Temozolomide (not in MeSH) Review |
| title | Progress of temozolomide in the treatment of recurrent high-grade gliomas |
| title_full | Progress of temozolomide in the treatment of recurrent high-grade gliomas |
| title_fullStr | Progress of temozolomide in the treatment of recurrent high-grade gliomas |
| title_full_unstemmed | Progress of temozolomide in the treatment of recurrent high-grade gliomas |
| title_short | Progress of temozolomide in the treatment of recurrent high-grade gliomas |
| title_sort | progress of temozolomide in the treatment of recurrent high grade gliomas |
| topic | Glioma Neoplasm recurrence, local Temozolomide (not in MeSH) Review |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/866 |
| work_keys_str_mv | AT jinduoli progressoftemozolomideinthetreatmentofrecurrenthighgradegliomas AT rongjiang progressoftemozolomideinthetreatmentofrecurrenthighgradegliomas AT jinhuanwang progressoftemozolomideinthetreatmentofrecurrenthighgradegliomas AT binwang progressoftemozolomideinthetreatmentofrecurrenthighgradegliomas AT chunhuama progressoftemozolomideinthetreatmentofrecurrenthighgradegliomas AT liweisun progressoftemozolomideinthetreatmentofrecurrenthighgradegliomas AT yuanlu progressoftemozolomideinthetreatmentofrecurrenthighgradegliomas AT guofanghou progressoftemozolomideinthetreatmentofrecurrenthighgradegliomas |