Systematic Analysis of the Expression and Prognosis of Fcγ Receptors in Clear Cell Renal Cell Carcinoma
BackgroundClear cell renal cell carcinoma (ccRCC) remains a common malignancy in the urinary system. Although dramatic progress was made in multimodal therapies, the improvement of its prognosis continues to be unsatisfactory. The antibody-binding crystallizable fragment (Fc) γ receptors (FcγRs) are...
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| Format: | Article |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.755936/full |
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| author | Wenyuan Nie Yong Yao Benjun Luo Jiyin Zhu Shaocheng Li Xiaoteng Yang Tao Luo Wei Liu Shibing Yan |
| author_facet | Wenyuan Nie Yong Yao Benjun Luo Jiyin Zhu Shaocheng Li Xiaoteng Yang Tao Luo Wei Liu Shibing Yan |
| author_sort | Wenyuan Nie |
| collection | DOAJ |
| description | BackgroundClear cell renal cell carcinoma (ccRCC) remains a common malignancy in the urinary system. Although dramatic progress was made in multimodal therapies, the improvement of its prognosis continues to be unsatisfactory. The antibody-binding crystallizable fragment (Fc) γ receptors (FcγRs) are expressed on the surface of leukocytes, to mediate antibody-induced cell-mediated anti-tumor responses when tumor-reactive antibodies are present. FcγRs have been studied extensively in immune cells, but rarely in cancer cells.MethodsONCOMINE, UALCAN, GEPIA, TIMER, TISIDB, Kaplan–Meier Plotter, SurvivalMeth, and STRING databases were utilized in this study.ResultsTranscriptional levels of FcγRs were upregulated in patients with ccRCC. There was a noticeable correlation between the over expressions of FCGR1A/B/C, FCGR2A, and clinical cancer stages/tumor grade in ccRCC patients. Besides, higher transcription levels of FcγRs were found to be associated with poor overall survival (OS) in ccRCC patients. Further, high DNA methylation levels of FcγRs were also observed in ccRCC patients, and higher DNA methylation levels of FcγRs were associated with shorter OS. Moreover, we also found that the expression of FcγRs was significantly correlated with immune infiltrates, namely, immune cells (NK, macrophages, Treg, cells) and immunoinhibitor (IL-10, TGFB1, and CTLA-4).ConclusionsOur study demonstrated that high DNA methylation levels of FcγRs lead to their low mRNA, protein levels, and poor prognosis in ccRCC patients, which may provide new insights into the choice of immunotherapy targets and prognostic biomarkers. |
| first_indexed | 2024-03-12T21:55:19Z |
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| id | doaj.art-9efd4e2d53164012b2e57eeb6c88dfaf |
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| language | English |
| last_indexed | 2024-03-12T21:55:19Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9efd4e2d53164012b2e57eeb6c88dfaf2023-07-25T19:16:32ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-03-011210.3389/fonc.2022.755936755936Systematic Analysis of the Expression and Prognosis of Fcγ Receptors in Clear Cell Renal Cell CarcinomaWenyuan NieYong YaoBenjun LuoJiyin ZhuShaocheng LiXiaoteng YangTao LuoWei LiuShibing YanBackgroundClear cell renal cell carcinoma (ccRCC) remains a common malignancy in the urinary system. Although dramatic progress was made in multimodal therapies, the improvement of its prognosis continues to be unsatisfactory. The antibody-binding crystallizable fragment (Fc) γ receptors (FcγRs) are expressed on the surface of leukocytes, to mediate antibody-induced cell-mediated anti-tumor responses when tumor-reactive antibodies are present. FcγRs have been studied extensively in immune cells, but rarely in cancer cells.MethodsONCOMINE, UALCAN, GEPIA, TIMER, TISIDB, Kaplan–Meier Plotter, SurvivalMeth, and STRING databases were utilized in this study.ResultsTranscriptional levels of FcγRs were upregulated in patients with ccRCC. There was a noticeable correlation between the over expressions of FCGR1A/B/C, FCGR2A, and clinical cancer stages/tumor grade in ccRCC patients. Besides, higher transcription levels of FcγRs were found to be associated with poor overall survival (OS) in ccRCC patients. Further, high DNA methylation levels of FcγRs were also observed in ccRCC patients, and higher DNA methylation levels of FcγRs were associated with shorter OS. Moreover, we also found that the expression of FcγRs was significantly correlated with immune infiltrates, namely, immune cells (NK, macrophages, Treg, cells) and immunoinhibitor (IL-10, TGFB1, and CTLA-4).ConclusionsOur study demonstrated that high DNA methylation levels of FcγRs lead to their low mRNA, protein levels, and poor prognosis in ccRCC patients, which may provide new insights into the choice of immunotherapy targets and prognostic biomarkers.https://www.frontiersin.org/articles/10.3389/fonc.2022.755936/fullclear cell renal cell carcinomaFcγ receptorprognostic valuebioinformatics analysistumor microenvironment |
| spellingShingle | Wenyuan Nie Yong Yao Benjun Luo Jiyin Zhu Shaocheng Li Xiaoteng Yang Tao Luo Wei Liu Shibing Yan Systematic Analysis of the Expression and Prognosis of Fcγ Receptors in Clear Cell Renal Cell Carcinoma Frontiers in Oncology clear cell renal cell carcinoma Fcγ receptor prognostic value bioinformatics analysis tumor microenvironment |
| title | Systematic Analysis of the Expression and Prognosis of Fcγ Receptors in Clear Cell Renal Cell Carcinoma |
| title_full | Systematic Analysis of the Expression and Prognosis of Fcγ Receptors in Clear Cell Renal Cell Carcinoma |
| title_fullStr | Systematic Analysis of the Expression and Prognosis of Fcγ Receptors in Clear Cell Renal Cell Carcinoma |
| title_full_unstemmed | Systematic Analysis of the Expression and Prognosis of Fcγ Receptors in Clear Cell Renal Cell Carcinoma |
| title_short | Systematic Analysis of the Expression and Prognosis of Fcγ Receptors in Clear Cell Renal Cell Carcinoma |
| title_sort | systematic analysis of the expression and prognosis of fcγ receptors in clear cell renal cell carcinoma |
| topic | clear cell renal cell carcinoma Fcγ receptor prognostic value bioinformatics analysis tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.755936/full |
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