MyoRing Implantation with and without Corneal Collagen Crosslinking for the Management of Keratoconus
Purpose: To evaluate the safety and efficacy of femtosecond laser-assisted MyoRing implantation with concurrent corneal collagen crosslinking (CXL) compared to MyoRing alone for the treatment of progressive keratoconus. Methods: A total of 60 patients were enrolled in this randomized controlle...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Knowledge E
2020-10-01
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| Series: | Journal of Ophthalmic & Vision Research |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/jovr.v15i4.7790 |
| _version_ | 1797989184473923584 |
|---|---|
| author | Mehrdad Mohammadpour Ahmad Masoumi Mahmoud Dehghan Mohammad Nasser Hashemian Shahab Addin Karami Alireza Mahmoudi |
| author_facet | Mehrdad Mohammadpour Ahmad Masoumi Mahmoud Dehghan Mohammad Nasser Hashemian Shahab Addin Karami Alireza Mahmoudi |
| author_sort | Mehrdad Mohammadpour |
| collection | DOAJ |
| description | Purpose: To evaluate the safety and efficacy of femtosecond laser-assisted MyoRing implantation with concurrent corneal collagen crosslinking (CXL) compared to MyoRing alone for the treatment of progressive keratoconus.
Methods: A total of 60 patients were enrolled in this randomized controlled trial. The patients were randomly allocated into two groups. In the first group, MyoRing was implanted, while in the second, it was inserted in the corneal stroma using the same technique, along with simultaneous CXL. Visual, refractive, topographic, and abberometric outcomes were measured preoperatively and at every postoperative visit.
Results: Data of 47 patients were available at the end of the study; 28 in the MyoRing group and 19 in the MyoRing + CXL group. The mean uncorrected distance visual acuity (UDVA) improved from 0.79
±
0.39 logMAR to 0.52
±
0.31 logMAR (P
<
0.05) in the MyoRing + CXL group and from 0.65
±
0.38 logMAR to 0.62
±
0.23 logMAR (P = 0.70) in the MyoRing group. CDVA changed from 0.33
±
0.19 logMAR to 0.25
±
0.16 logMAR (P = 0.10) in the MyoRing + CXL group and 0.32
±
0.22 logMAR to 0.33
±
0.17 logMAR (P
>
0.50) in the MyoRing group. The mean keratometry (Km) decreased from 47.5
±
2.7 D to 43.8
±
3.2 D (P
<
0.001) in the MyoRing group and 49.3
±
3.4 D to 45.1
±
3.0 D (P
<
0.001) in the MyoRing + CXL group. Besides, horizontal coma was significantly lower in the MyoRing + CXL group (P = 0.022).
Conclusion: MyoRing insertion combined with CXL is a safe and effective method for the treatment of keratoconus. The visual and topographic outcomes were comparable to that for MyoRing insertion after 10 months; however, horizontal coma was significantly lower in the MyoRing + CXL group. |
| first_indexed | 2024-04-11T08:16:10Z |
| format | Article |
| id | doaj.art-9effae276497486ea1c3f878fe04a4af |
| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-11T08:16:10Z |
| publishDate | 2020-10-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-9effae276497486ea1c3f878fe04a4af2022-12-22T04:35:09ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2020-10-011548649210.18502/jovr.v15i4.7790MyoRing Implantation with and without Corneal Collagen Crosslinking for the Management of KeratoconusMehrdad Mohammadpour0Ahmad Masoumi1Mahmoud Dehghan2Mohammad Nasser Hashemian3Shahab Addin Karami4Alireza Mahmoudi5 Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IranPurpose: To evaluate the safety and efficacy of femtosecond laser-assisted MyoRing implantation with concurrent corneal collagen crosslinking (CXL) compared to MyoRing alone for the treatment of progressive keratoconus. Methods: A total of 60 patients were enrolled in this randomized controlled trial. The patients were randomly allocated into two groups. In the first group, MyoRing was implanted, while in the second, it was inserted in the corneal stroma using the same technique, along with simultaneous CXL. Visual, refractive, topographic, and abberometric outcomes were measured preoperatively and at every postoperative visit. Results: Data of 47 patients were available at the end of the study; 28 in the MyoRing group and 19 in the MyoRing + CXL group. The mean uncorrected distance visual acuity (UDVA) improved from 0.79 ± 0.39 logMAR to 0.52 ± 0.31 logMAR (P < 0.05) in the MyoRing + CXL group and from 0.65 ± 0.38 logMAR to 0.62 ± 0.23 logMAR (P = 0.70) in the MyoRing group. CDVA changed from 0.33 ± 0.19 logMAR to 0.25 ± 0.16 logMAR (P = 0.10) in the MyoRing + CXL group and 0.32 ± 0.22 logMAR to 0.33 ± 0.17 logMAR (P > 0.50) in the MyoRing group. The mean keratometry (Km) decreased from 47.5 ± 2.7 D to 43.8 ± 3.2 D (P < 0.001) in the MyoRing group and 49.3 ± 3.4 D to 45.1 ± 3.0 D (P < 0.001) in the MyoRing + CXL group. Besides, horizontal coma was significantly lower in the MyoRing + CXL group (P = 0.022). Conclusion: MyoRing insertion combined with CXL is a safe and effective method for the treatment of keratoconus. The visual and topographic outcomes were comparable to that for MyoRing insertion after 10 months; however, horizontal coma was significantly lower in the MyoRing + CXL group.https://doi.org/10.18502/jovr.v15i4.7790corneal collagen crosslinkingkeratoconusmyoring |
| spellingShingle | Mehrdad Mohammadpour Ahmad Masoumi Mahmoud Dehghan Mohammad Nasser Hashemian Shahab Addin Karami Alireza Mahmoudi MyoRing Implantation with and without Corneal Collagen Crosslinking for the Management of Keratoconus Journal of Ophthalmic & Vision Research corneal collagen crosslinking keratoconus myoring |
| title | MyoRing Implantation with and without Corneal Collagen Crosslinking for the Management of Keratoconus |
| title_full | MyoRing Implantation with and without Corneal Collagen Crosslinking for the Management of Keratoconus |
| title_fullStr | MyoRing Implantation with and without Corneal Collagen Crosslinking for the Management of Keratoconus |
| title_full_unstemmed | MyoRing Implantation with and without Corneal Collagen Crosslinking for the Management of Keratoconus |
| title_short | MyoRing Implantation with and without Corneal Collagen Crosslinking for the Management of Keratoconus |
| title_sort | myoring implantation with and without corneal collagen crosslinking for the management of keratoconus |
| topic | corneal collagen crosslinking keratoconus myoring |
| url | https://doi.org/10.18502/jovr.v15i4.7790 |
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