Macular cutaneous amyloidosis treated with methyl aminolevulinate and daylight photodynamic therapy: A case report
Primary cutaneous amyloidosis is characterized by polymerization of extracellular amyloid precursors in β-pleated sheet conformation into larger fibrillar aggregates. Observation in models of Alzheimer’s disease have noted that amyloid polymerization in the brain is blocked by reactive oxygen specie...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-02-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X19829617 |
| _version_ | 1818512610059878400 |
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| author | Christina M Huang Lauren Lam Robert Gniadecki |
| author_facet | Christina M Huang Lauren Lam Robert Gniadecki |
| author_sort | Christina M Huang |
| collection | DOAJ |
| description | Primary cutaneous amyloidosis is characterized by polymerization of extracellular amyloid precursors in β-pleated sheet conformation into larger fibrillar aggregates. Observation in models of Alzheimer’s disease have noted that amyloid polymerization in the brain is blocked by reactive oxygen species. Singlet oxygen is formed in the skin during methyl aminolevulinate photodynamic therapy. Therefore, we speculate that type II photochemical reaction is responsible for the observed therapeutic activity of methyl aminolevulinate photodynamic therapy in our patient with primary cutaneous amyloidosis. Our case is the first report demonstrating the efficacy of daylight photodynamic therapy in primary cutaneous amyloidosis. Daylight photodynamic therapy may provide a convenient and cost-effective therapeutic option in primary cutaneous amyloidosis, and its efficacy should be further confirmed in prospective trials. |
| first_indexed | 2024-12-10T23:49:21Z |
| format | Article |
| id | doaj.art-9effd3575479453997c7791b5eb74a8b |
| institution | Directory Open Access Journal |
| issn | 2050-313X |
| language | English |
| last_indexed | 2024-12-10T23:49:21Z |
| publishDate | 2019-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj.art-9effd3575479453997c7791b5eb74a8b2022-12-22T01:28:49ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2019-02-01710.1177/2050313X19829617Macular cutaneous amyloidosis treated with methyl aminolevulinate and daylight photodynamic therapy: A case reportChristina M Huang0Lauren Lam1Robert Gniadecki2Division of Dermatology, University of Alberta, Edmonton, AB, CanadaDivision of Dermatology, University of Alberta, Edmonton, AB, CanadaDivision of Dermatology, University of Alberta, Edmonton, AB, CanadaPrimary cutaneous amyloidosis is characterized by polymerization of extracellular amyloid precursors in β-pleated sheet conformation into larger fibrillar aggregates. Observation in models of Alzheimer’s disease have noted that amyloid polymerization in the brain is blocked by reactive oxygen species. Singlet oxygen is formed in the skin during methyl aminolevulinate photodynamic therapy. Therefore, we speculate that type II photochemical reaction is responsible for the observed therapeutic activity of methyl aminolevulinate photodynamic therapy in our patient with primary cutaneous amyloidosis. Our case is the first report demonstrating the efficacy of daylight photodynamic therapy in primary cutaneous amyloidosis. Daylight photodynamic therapy may provide a convenient and cost-effective therapeutic option in primary cutaneous amyloidosis, and its efficacy should be further confirmed in prospective trials.https://doi.org/10.1177/2050313X19829617 |
| spellingShingle | Christina M Huang Lauren Lam Robert Gniadecki Macular cutaneous amyloidosis treated with methyl aminolevulinate and daylight photodynamic therapy: A case report SAGE Open Medical Case Reports |
| title | Macular cutaneous amyloidosis treated with methyl aminolevulinate and daylight photodynamic therapy: A case report |
| title_full | Macular cutaneous amyloidosis treated with methyl aminolevulinate and daylight photodynamic therapy: A case report |
| title_fullStr | Macular cutaneous amyloidosis treated with methyl aminolevulinate and daylight photodynamic therapy: A case report |
| title_full_unstemmed | Macular cutaneous amyloidosis treated with methyl aminolevulinate and daylight photodynamic therapy: A case report |
| title_short | Macular cutaneous amyloidosis treated with methyl aminolevulinate and daylight photodynamic therapy: A case report |
| title_sort | macular cutaneous amyloidosis treated with methyl aminolevulinate and daylight photodynamic therapy a case report |
| url | https://doi.org/10.1177/2050313X19829617 |
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