The effect of undernutrition on sputum culture conversion and treatment outcomes among people with multidrug-resistant tuberculosis: a systematic review and meta-analysis
Objectives: We aimed to evaluate the effect of undernutrition on sputum culture conversion and treatment outcomes among people with multidrug-resistant tuberculosis (MDR-TB). Methods: We searched for publications in the Medline, Embase, Scopus, and Web of Science databases. We conducted a random-eff...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S120197122200635X |
| _version_ | 1797943105430749184 |
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| author | Fasil Wagnew Kefyalew Addis Alene Matthew Kelly Darren Gray |
| author_facet | Fasil Wagnew Kefyalew Addis Alene Matthew Kelly Darren Gray |
| author_sort | Fasil Wagnew |
| collection | DOAJ |
| description | Objectives: We aimed to evaluate the effect of undernutrition on sputum culture conversion and treatment outcomes among people with multidrug-resistant tuberculosis (MDR-TB). Methods: We searched for publications in the Medline, Embase, Scopus, and Web of Science databases. We conducted a random-effect meta-analysis to estimate the effects of undernutrition on sputum culture conversion and treatment outcomes. Hazard ratio (HR) for sputum culture conversion and odds ratio (OR) for end-of-treatment outcomes, with 95% CI, were used to summarize the effect estimates. Potential publication bias was checked using funnel plots and Egger's tests. Results: Of the 2358 records screened, 63 studies comprising a total of 31,583 people with MDR-TB were included. Undernutrition was significantly associated with a longer time to sputum culture conversion (HR 0.7, 95% CI 0.6-0.9, I2 = 67·1%), and a higher rate of mortality (OR 2.8, 95% CI 2.1-3.6, I2 = 21%) and unsuccessful treatment outcomes (OR 1.8, 95% CI 1.5-2.1, I2 = 70%). There was no significant publication bias in the included studies. Conclusion: Undernutrition was significantly associated with unsuccessful treatment outcomes, including mortality and longer time to sputum culture conversion among people with MDR-TB. These findings have implications for supporting targeted nutritional interventions alongside standardized TB drugs. |
| first_indexed | 2024-04-10T20:18:00Z |
| format | Article |
| id | doaj.art-9f0066c8be9f43bebc7fc56b5822eb6b |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-10T20:18:00Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-9f0066c8be9f43bebc7fc56b5822eb6b2023-01-26T04:44:35ZengElsevierInternational Journal of Infectious Diseases1201-97122023-02-0112793105The effect of undernutrition on sputum culture conversion and treatment outcomes among people with multidrug-resistant tuberculosis: a systematic review and meta-analysisFasil Wagnew0Kefyalew Addis Alene1Matthew Kelly2Darren Gray3National Centre for Epidemiology and Population Health (NCEPH), College of Health and Medicine, The Australian National University, Canberra, Australia; College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia; Corresponding author.Geospatial and Tuberculosis Research Team, Telethon Kids Institute, Nedlands, Western Australia, Australia; School of Population Health, Faculty of Health Sciences, Curtin University, Bentley, AustraliaNational Centre for Epidemiology and Population Health (NCEPH), College of Health and Medicine, The Australian National University, Canberra, AustraliaNational Centre for Epidemiology and Population Health (NCEPH), College of Health and Medicine, The Australian National University, Canberra, AustraliaObjectives: We aimed to evaluate the effect of undernutrition on sputum culture conversion and treatment outcomes among people with multidrug-resistant tuberculosis (MDR-TB). Methods: We searched for publications in the Medline, Embase, Scopus, and Web of Science databases. We conducted a random-effect meta-analysis to estimate the effects of undernutrition on sputum culture conversion and treatment outcomes. Hazard ratio (HR) for sputum culture conversion and odds ratio (OR) for end-of-treatment outcomes, with 95% CI, were used to summarize the effect estimates. Potential publication bias was checked using funnel plots and Egger's tests. Results: Of the 2358 records screened, 63 studies comprising a total of 31,583 people with MDR-TB were included. Undernutrition was significantly associated with a longer time to sputum culture conversion (HR 0.7, 95% CI 0.6-0.9, I2 = 67·1%), and a higher rate of mortality (OR 2.8, 95% CI 2.1-3.6, I2 = 21%) and unsuccessful treatment outcomes (OR 1.8, 95% CI 1.5-2.1, I2 = 70%). There was no significant publication bias in the included studies. Conclusion: Undernutrition was significantly associated with unsuccessful treatment outcomes, including mortality and longer time to sputum culture conversion among people with MDR-TB. These findings have implications for supporting targeted nutritional interventions alongside standardized TB drugs.http://www.sciencedirect.com/science/article/pii/S120197122200635XUndernutritionMDR-TBSputum culture conversionTreatment outcomesMeta-analysis |
| spellingShingle | Fasil Wagnew Kefyalew Addis Alene Matthew Kelly Darren Gray The effect of undernutrition on sputum culture conversion and treatment outcomes among people with multidrug-resistant tuberculosis: a systematic review and meta-analysis International Journal of Infectious Diseases Undernutrition MDR-TB Sputum culture conversion Treatment outcomes Meta-analysis |
| title | The effect of undernutrition on sputum culture conversion and treatment outcomes among people with multidrug-resistant tuberculosis: a systematic review and meta-analysis |
| title_full | The effect of undernutrition on sputum culture conversion and treatment outcomes among people with multidrug-resistant tuberculosis: a systematic review and meta-analysis |
| title_fullStr | The effect of undernutrition on sputum culture conversion and treatment outcomes among people with multidrug-resistant tuberculosis: a systematic review and meta-analysis |
| title_full_unstemmed | The effect of undernutrition on sputum culture conversion and treatment outcomes among people with multidrug-resistant tuberculosis: a systematic review and meta-analysis |
| title_short | The effect of undernutrition on sputum culture conversion and treatment outcomes among people with multidrug-resistant tuberculosis: a systematic review and meta-analysis |
| title_sort | effect of undernutrition on sputum culture conversion and treatment outcomes among people with multidrug resistant tuberculosis a systematic review and meta analysis |
| topic | Undernutrition MDR-TB Sputum culture conversion Treatment outcomes Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S120197122200635X |
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