Thymic epithelial cell fate and potency in early organogenesis assessed by single cell transcriptional and functional analysis

Thymic epithelial cell fate and potency in early organogenesis assessed by single cell transcriptional and functional analysis

During development, cortical (c) and medullary (m) thymic epithelial cells (TEC) arise from the third pharyngeal pouch endoderm. Current models suggest that within the thymic primordium most TEC exist in a bipotent/common thymic epithelial progenitor cell (TEPC) state able to generate both cTEC and...

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Bibliographic Details
Main Authors: Alison Mary Farley, An Chengrui, Sam Palmer, Dong Liu, Anastasia I. Kousa, Paul Rouse, Viktoria Major, Joanna Sweetman, Jan Morys, Andrea Corsinotti, Jennifer Nichols, Janice Ure, Renee McLay, Luke Boulter, S. Jon Chapman, Simon R. Tomlinson, C. Clare Blackburn
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
thymus
epithelial cells
cell fate
single cell
transcriptome
potency
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1202163/full

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