Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis
For the development of vaccine strategies to generate efficient protection against chronic infections such as parasitic diseases, and more precisely schistosomiasis, controlling pathology could be more relevant than controlling the infection itself. Such strategies, motivated by the need for a cost-...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
1998-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000700012 |
| _version_ | 1827879869498785792 |
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| author | Gilles Riveau Odile Poulain-Godefroy Loïc Dupré Franck Remoué Nathalie Mielcarek Camille Locht André Capron |
| author_facet | Gilles Riveau Odile Poulain-Godefroy Loïc Dupré Franck Remoué Nathalie Mielcarek Camille Locht André Capron |
| author_sort | Gilles Riveau |
| collection | DOAJ |
| description | For the development of vaccine strategies to generate efficient protection against chronic infections such as parasitic diseases, and more precisely schistosomiasis, controlling pathology could be more relevant than controlling the infection itself. Such strategies, motivated by the need for a cost-effective complement to existing control measures, should focus on parasite molecules involved in fecundity, because in metazoan parasite infections pathology is usually linked to the output of viable eggs. In numerous animal models, vaccination with glutathione S-transferases of 28kDa has been shown to generate an immune response strongly limiting the worm fecundity, in addition to the reduction of the parasite burden. Recent data on acquired immunity directed to 28GST in infected human populations, and new development to draw adapted vaccine formulations, are presented. |
| first_indexed | 2024-03-12T18:12:30Z |
| format | Article |
| id | doaj.art-9f03ef59e26a4abb96f11ad5f374021c |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:12:30Z |
| publishDate | 1998-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-9f03ef59e26a4abb96f11ad5f374021c2023-08-02T09:15:11ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601998-01-0193879410.1590/S0074-02761998000700012Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasisGilles RiveauOdile Poulain-GodefroyLoïc DupréFranck RemouéNathalie MielcarekCamille LochtAndré CapronFor the development of vaccine strategies to generate efficient protection against chronic infections such as parasitic diseases, and more precisely schistosomiasis, controlling pathology could be more relevant than controlling the infection itself. Such strategies, motivated by the need for a cost-effective complement to existing control measures, should focus on parasite molecules involved in fecundity, because in metazoan parasite infections pathology is usually linked to the output of viable eggs. In numerous animal models, vaccination with glutathione S-transferases of 28kDa has been shown to generate an immune response strongly limiting the worm fecundity, in addition to the reduction of the parasite burden. Recent data on acquired immunity directed to 28GST in infected human populations, and new development to draw adapted vaccine formulations, are presented.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000700012schistosomiasis28GSTvaccineimmune responselive vectorsnucleic acid vaccine |
| spellingShingle | Gilles Riveau Odile Poulain-Godefroy Loïc Dupré Franck Remoué Nathalie Mielcarek Camille Locht André Capron Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis Memorias do Instituto Oswaldo Cruz schistosomiasis 28GST vaccine immune response live vectors nucleic acid vaccine |
| title | Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis |
| title_full | Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis |
| title_fullStr | Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis |
| title_full_unstemmed | Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis |
| title_short | Glutathione S-transferases of 28kDa as major vaccine candidates against schistosomiasis |
| title_sort | glutathione s transferases of 28kda as major vaccine candidates against schistosomiasis |
| topic | schistosomiasis 28GST vaccine immune response live vectors nucleic acid vaccine |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000700012 |
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