In vitro cell models merging circadian rhythms and brain waves for personalized neuromedicine
Summary: New evidence is emerging about the dynamics of interaction between circadian rhythms and brain waves, whose coordination occurs through the entrainment process. The so-called “oscillopathies” or dysfunctions in synchronization of neuronal oscillation in key brain networks lead to the onset...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222017497 |
| _version_ | 1817971540435664896 |
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| author | Barbara Pavan Anna Bianchi Giada Botti |
| author_facet | Barbara Pavan Anna Bianchi Giada Botti |
| author_sort | Barbara Pavan |
| collection | DOAJ |
| description | Summary: New evidence is emerging about the dynamics of interaction between circadian rhythms and brain waves, whose coordination occurs through the entrainment process. The so-called “oscillopathies” or dysfunctions in synchronization of neuronal oscillation in key brain networks lead to the onset of neurodegenerative diseases. A typical example of alteration is insomnia, a risk factor for the oscillopathies, increasingly widespread worldwide. Recently, synchronization of circadian rhythms in cell cultures has allowed an improvement in the physiological relevance of responses to stimuli. Furthermore, brain organoids and neurons cultured in microfluidic systems are the latest frontiers for in vitro reproduction of rhythmic electrical signals. In this review, the combination of these in vitro experimental approaches is proposed as suitable for a more direct investigation on the common mechanisms and neurophysiological substrates underlying brain waves and circadian oscillations, and useful to evaluate the effects of “oscillotherapeutic” drugs for personalized neuromedicine. |
| first_indexed | 2024-04-13T20:48:16Z |
| format | Article |
| id | doaj.art-9f054af586d14f25b550305a0eab3e92 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-13T20:48:16Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-9f054af586d14f25b550305a0eab3e922022-12-22T02:30:36ZengElsevieriScience2589-00422022-12-012512105477In vitro cell models merging circadian rhythms and brain waves for personalized neuromedicineBarbara Pavan0Anna Bianchi1Giada Botti2Department of Neuroscience and Rehabilitation, Section of Physiology, via L. Borsari, 46, University of Ferrara, 44121 Ferrara, Italy; Center for Translational Neurophysiology of Speech and Communication (CTNSC), Italian Institute of Technology (IIT), via Fossato di Mortara 17-19, 44121 Ferrara, Italy; Corresponding authorDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, via Fossato di Mortara, 17, 44121 Ferrara, ItalyDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, via Fossato di Mortara, 17, 44121 Ferrara, ItalySummary: New evidence is emerging about the dynamics of interaction between circadian rhythms and brain waves, whose coordination occurs through the entrainment process. The so-called “oscillopathies” or dysfunctions in synchronization of neuronal oscillation in key brain networks lead to the onset of neurodegenerative diseases. A typical example of alteration is insomnia, a risk factor for the oscillopathies, increasingly widespread worldwide. Recently, synchronization of circadian rhythms in cell cultures has allowed an improvement in the physiological relevance of responses to stimuli. Furthermore, brain organoids and neurons cultured in microfluidic systems are the latest frontiers for in vitro reproduction of rhythmic electrical signals. In this review, the combination of these in vitro experimental approaches is proposed as suitable for a more direct investigation on the common mechanisms and neurophysiological substrates underlying brain waves and circadian oscillations, and useful to evaluate the effects of “oscillotherapeutic” drugs for personalized neuromedicine.http://www.sciencedirect.com/science/article/pii/S2589004222017497Cellular physiologyNeuroscienceCellular neuroscience |
| spellingShingle | Barbara Pavan Anna Bianchi Giada Botti In vitro cell models merging circadian rhythms and brain waves for personalized neuromedicine iScience Cellular physiology Neuroscience Cellular neuroscience |
| title | In vitro cell models merging circadian rhythms and brain waves for personalized neuromedicine |
| title_full | In vitro cell models merging circadian rhythms and brain waves for personalized neuromedicine |
| title_fullStr | In vitro cell models merging circadian rhythms and brain waves for personalized neuromedicine |
| title_full_unstemmed | In vitro cell models merging circadian rhythms and brain waves for personalized neuromedicine |
| title_short | In vitro cell models merging circadian rhythms and brain waves for personalized neuromedicine |
| title_sort | in vitro cell models merging circadian rhythms and brain waves for personalized neuromedicine |
| topic | Cellular physiology Neuroscience Cellular neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222017497 |
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