Effects of Intermittent Fasting on Response to Tyrosine Kinase Inhibitors (TKIs) in Patients With Chronic Myeloid Leukemia: An Outcome of European LeukemiaNet Project
The overall survival of patients with Chronic Myeloid Leukemia (CML) treated by using tyrosine kinase inhibitors (TKIs) is very close to that of the healthy population. However, little is known about the effect of specific measures such as intermittent fasting, especially during Ramadan period. A 3-...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-04-01
|
| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/10732748211009256 |
| _version_ | 1819084995310911488 |
|---|---|
| author | Mohamed A. Yassin MBBS, MSc Rola S. Ghasoub BSC Mahmood B. Aldapt MD Mohammad A. Abdulla MD Prem Chandra PhD Hawraa M. Shwaylia MD Abdulqadir J. Nashwan BSN, MSN Nancy A. Kassem BSC Susanna J. Akiki PhD |
| author_facet | Mohamed A. Yassin MBBS, MSc Rola S. Ghasoub BSC Mahmood B. Aldapt MD Mohammad A. Abdulla MD Prem Chandra PhD Hawraa M. Shwaylia MD Abdulqadir J. Nashwan BSN, MSN Nancy A. Kassem BSC Susanna J. Akiki PhD |
| author_sort | Mohamed A. Yassin MBBS, MSc |
| collection | DOAJ |
| description | The overall survival of patients with Chronic Myeloid Leukemia (CML) treated by using tyrosine kinase inhibitors (TKIs) is very close to that of the healthy population. However, little is known about the effect of specific measures such as intermittent fasting, especially during Ramadan period. A 3-year retrospective study was conducted to evaluate the effect of fasting on patients with CML receiving TKIs by evaluating certain clinical, hematological, and molecular parameters. A total of 49 patients were eligible, with a median age of 46 years (range: 22-86), of these 36 (73.5%) were males and 13 (26.5%) were females. Twenty-seven (55%) patients are Middle Eastern, while 16 (32.7%) from the Indian subcontinent, and 6 (12.3%) Africans. Imatinib was the most common TKI; used in 25 patients (51%). The mean White blood cells (WBCs), neutrophils, and BCR-ABL were found to be reduced after fasting compared to before and during with statistical difference. The use of TKIs while fasting did not result in significant changes in hematological nor BCR-ABL levels in our study. Patients who wish to practice intermittent fasting may be reassured in this regard, yet physicians can adopt the safe trial approach, where they allow the patients to fast, but with instructions such as when to break fasting. |
| first_indexed | 2024-12-21T20:57:19Z |
| format | Article |
| id | doaj.art-9f068dcc557a4e9e89e3fde45667ba06 |
| institution | Directory Open Access Journal |
| issn | 1073-2748 |
| language | English |
| last_indexed | 2024-12-21T20:57:19Z |
| publishDate | 2021-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj.art-9f068dcc557a4e9e89e3fde45667ba062022-12-21T18:50:32ZengSAGE PublishingCancer Control1073-27482021-04-012810.1177/10732748211009256Effects of Intermittent Fasting on Response to Tyrosine Kinase Inhibitors (TKIs) in Patients With Chronic Myeloid Leukemia: An Outcome of European LeukemiaNet ProjectMohamed A. Yassin MBBS, MSc0Rola S. Ghasoub BSC1Mahmood B. Aldapt MD2Mohammad A. Abdulla MD3Prem Chandra PhD4Hawraa M. Shwaylia MD5Abdulqadir J. Nashwan BSN, MSN6Nancy A. Kassem BSC7Susanna J. Akiki PhD8 College of Medicine, Qatar University (QU), Doha, Qatar Department of Pharmacy, National Center for Cancer Care and Research (NCCCR), , Doha, Qatar Hematology Section, Medical Oncology, National Center for Cancer Care and Research (NCCCR), , Doha, Qatar Hematology Section, Medical Oncology, National Center for Cancer Care and Research (NCCCR), , Doha, Qatar Medical Research Center, , Doha, Qatar Hematology Section, Medical Oncology, National Center for Cancer Care and Research (NCCCR), , Doha, Qatar Department of Nursing, Hazm Mebaireek General Hospital (HMGH), , Doha, Qatar College of Medicine, Qatar University (QU), Doha, Qatar Diagnostic Genomic Division, , Doha, QatarThe overall survival of patients with Chronic Myeloid Leukemia (CML) treated by using tyrosine kinase inhibitors (TKIs) is very close to that of the healthy population. However, little is known about the effect of specific measures such as intermittent fasting, especially during Ramadan period. A 3-year retrospective study was conducted to evaluate the effect of fasting on patients with CML receiving TKIs by evaluating certain clinical, hematological, and molecular parameters. A total of 49 patients were eligible, with a median age of 46 years (range: 22-86), of these 36 (73.5%) were males and 13 (26.5%) were females. Twenty-seven (55%) patients are Middle Eastern, while 16 (32.7%) from the Indian subcontinent, and 6 (12.3%) Africans. Imatinib was the most common TKI; used in 25 patients (51%). The mean White blood cells (WBCs), neutrophils, and BCR-ABL were found to be reduced after fasting compared to before and during with statistical difference. The use of TKIs while fasting did not result in significant changes in hematological nor BCR-ABL levels in our study. Patients who wish to practice intermittent fasting may be reassured in this regard, yet physicians can adopt the safe trial approach, where they allow the patients to fast, but with instructions such as when to break fasting.https://doi.org/10.1177/10732748211009256 |
| spellingShingle | Mohamed A. Yassin MBBS, MSc Rola S. Ghasoub BSC Mahmood B. Aldapt MD Mohammad A. Abdulla MD Prem Chandra PhD Hawraa M. Shwaylia MD Abdulqadir J. Nashwan BSN, MSN Nancy A. Kassem BSC Susanna J. Akiki PhD Effects of Intermittent Fasting on Response to Tyrosine Kinase Inhibitors (TKIs) in Patients With Chronic Myeloid Leukemia: An Outcome of European LeukemiaNet Project Cancer Control |
| title | Effects of Intermittent Fasting on Response to Tyrosine Kinase Inhibitors (TKIs) in Patients With Chronic Myeloid Leukemia: An Outcome of European LeukemiaNet Project |
| title_full | Effects of Intermittent Fasting on Response to Tyrosine Kinase Inhibitors (TKIs) in Patients With Chronic Myeloid Leukemia: An Outcome of European LeukemiaNet Project |
| title_fullStr | Effects of Intermittent Fasting on Response to Tyrosine Kinase Inhibitors (TKIs) in Patients With Chronic Myeloid Leukemia: An Outcome of European LeukemiaNet Project |
| title_full_unstemmed | Effects of Intermittent Fasting on Response to Tyrosine Kinase Inhibitors (TKIs) in Patients With Chronic Myeloid Leukemia: An Outcome of European LeukemiaNet Project |
| title_short | Effects of Intermittent Fasting on Response to Tyrosine Kinase Inhibitors (TKIs) in Patients With Chronic Myeloid Leukemia: An Outcome of European LeukemiaNet Project |
| title_sort | effects of intermittent fasting on response to tyrosine kinase inhibitors tkis in patients with chronic myeloid leukemia an outcome of european leukemianet project |
| url | https://doi.org/10.1177/10732748211009256 |
| work_keys_str_mv | AT mohamedayassinmbbsmsc effectsofintermittentfastingonresponsetotyrosinekinaseinhibitorstkisinpatientswithchronicmyeloidleukemiaanoutcomeofeuropeanleukemianetproject AT rolasghasoubbsc effectsofintermittentfastingonresponsetotyrosinekinaseinhibitorstkisinpatientswithchronicmyeloidleukemiaanoutcomeofeuropeanleukemianetproject AT mahmoodbaldaptmd effectsofintermittentfastingonresponsetotyrosinekinaseinhibitorstkisinpatientswithchronicmyeloidleukemiaanoutcomeofeuropeanleukemianetproject AT mohammadaabdullamd effectsofintermittentfastingonresponsetotyrosinekinaseinhibitorstkisinpatientswithchronicmyeloidleukemiaanoutcomeofeuropeanleukemianetproject AT premchandraphd effectsofintermittentfastingonresponsetotyrosinekinaseinhibitorstkisinpatientswithchronicmyeloidleukemiaanoutcomeofeuropeanleukemianetproject AT hawraamshwayliamd effectsofintermittentfastingonresponsetotyrosinekinaseinhibitorstkisinpatientswithchronicmyeloidleukemiaanoutcomeofeuropeanleukemianetproject AT abdulqadirjnashwanbsnmsn effectsofintermittentfastingonresponsetotyrosinekinaseinhibitorstkisinpatientswithchronicmyeloidleukemiaanoutcomeofeuropeanleukemianetproject AT nancyakassembsc effectsofintermittentfastingonresponsetotyrosinekinaseinhibitorstkisinpatientswithchronicmyeloidleukemiaanoutcomeofeuropeanleukemianetproject AT susannajakikiphd effectsofintermittentfastingonresponsetotyrosinekinaseinhibitorstkisinpatientswithchronicmyeloidleukemiaanoutcomeofeuropeanleukemianetproject |