Thyroid hormone function in the rat testis
Thyroid hormones are emerging regulators of testicular function since Sertoli, germ and Leydig cells are found to express thyroid hormone receptors. These testicular cells also express deiodinases which are capable of converting the pro-hormone T4 to the active thyroid hormone T3, or inactivating T3...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-11-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00188/full |
| _version_ | 1828473490134532096 |
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| author | Ying eGao Will M. eLee C Yan eCheng |
| author_facet | Ying eGao Will M. eLee C Yan eCheng |
| author_sort | Ying eGao |
| collection | DOAJ |
| description | Thyroid hormones are emerging regulators of testicular function since Sertoli, germ and Leydig cells are found to express thyroid hormone receptors. These testicular cells also express deiodinases which are capable of converting the pro-hormone T4 to the active thyroid hormone T3, or inactivating T3 or T4 to a non-biologically active form. Furthermore, thyroid hormone transporters are also found in the testis. Thus, the testis is equipped with the transporters and the enzymes necessary to maintain the optimal level of thyroid hormone in the seminiferous epithelium, as well as the specific thyroid hormone receptors to execute thyroid hormone action in response to different stages of the epithelial cycle of spermatogenesis. Studies using genetic models and/or goitrogens (e.g., PTU (propylthiouracil)) have illustrated a tight physiological relationship between thyroid hormone and testicular function, in particular Sertoli cell differentiation status, mitotic activity, gap junction function and blood-testis barrier (BTB) assembly. These findings are briefly summarized and discussed herein. |
| first_indexed | 2024-12-11T05:45:11Z |
| format | Article |
| id | doaj.art-9f0758f93ca247db86b471f8a705f3d8 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-11T05:45:11Z |
| publishDate | 2014-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9f0758f93ca247db86b471f8a705f3d82022-12-22T01:19:00ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922014-11-01510.3389/fendo.2014.00188118995Thyroid hormone function in the rat testisYing eGao0Will M. eLee1C Yan eCheng2Population CouncilUniversity of Hong KongPopulation CouncilThyroid hormones are emerging regulators of testicular function since Sertoli, germ and Leydig cells are found to express thyroid hormone receptors. These testicular cells also express deiodinases which are capable of converting the pro-hormone T4 to the active thyroid hormone T3, or inactivating T3 or T4 to a non-biologically active form. Furthermore, thyroid hormone transporters are also found in the testis. Thus, the testis is equipped with the transporters and the enzymes necessary to maintain the optimal level of thyroid hormone in the seminiferous epithelium, as well as the specific thyroid hormone receptors to execute thyroid hormone action in response to different stages of the epithelial cycle of spermatogenesis. Studies using genetic models and/or goitrogens (e.g., PTU (propylthiouracil)) have illustrated a tight physiological relationship between thyroid hormone and testicular function, in particular Sertoli cell differentiation status, mitotic activity, gap junction function and blood-testis barrier (BTB) assembly. These findings are briefly summarized and discussed herein.http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00188/fullBlood-Testis BarrierSpermatogenesisTestisThyroid Hormonesgap junctionseminiferous epithelial cycle. |
| spellingShingle | Ying eGao Will M. eLee C Yan eCheng Thyroid hormone function in the rat testis Frontiers in Endocrinology Blood-Testis Barrier Spermatogenesis Testis Thyroid Hormones gap junction seminiferous epithelial cycle. |
| title | Thyroid hormone function in the rat testis |
| title_full | Thyroid hormone function in the rat testis |
| title_fullStr | Thyroid hormone function in the rat testis |
| title_full_unstemmed | Thyroid hormone function in the rat testis |
| title_short | Thyroid hormone function in the rat testis |
| title_sort | thyroid hormone function in the rat testis |
| topic | Blood-Testis Barrier Spermatogenesis Testis Thyroid Hormones gap junction seminiferous epithelial cycle. |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00188/full |
| work_keys_str_mv | AT yingegao thyroidhormonefunctionintherattestis AT willmelee thyroidhormonefunctionintherattestis AT cyanecheng thyroidhormonefunctionintherattestis |