Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes

Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes

IBMPFD/ALS is a genetic disorder caused by a single amino acid mutation on the p97 ATPase, promoting ATPase activity and cofactor dysregulation. The disease mechanism underlying p97 ATPase malfunction remains unclear. To understand how the mutation alters the ATPase regulation, we assembled a full-l...

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Bibliographic Details
Main Authors: Purbasha Nandi, Shan Li, Rod Carlo A. Columbres, Feng Wang, Dewight R. Williams, Yu-Ping Poh, Tsui-Fen Chou, Po-Lin Chiu
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
p97 ATPase
p97<sup>R155H</sup> mutation
p47 cofactor
arginine finger
IBMPFD
single-particle cryo-EM
Online Access:https://www.mdpi.com/1422-0067/22/15/8079

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