Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage

Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage

Abstract Background Neuroinflammation often develops in sepsis leading to activation of cerebral endothelium, increased permeability of the blood-brain barrier (BBB), and neutrophil infiltration. We have identified protein kinase C-delta (PKCδ) as a critical regulator of the inflammatory response an...

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Bibliographic Details
Main Authors: Yuan Tang, Fariborz Soroush, Shuang Sun, Elisabetta Liverani, Jordan C. Langston, Qingliang Yang, Laurie E. Kilpatrick, Mohammad F. Kiani
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Neuroinflammation
Subjects:
Blood-brain barrier
Protein kinase C-delta
Microvascular endothelial cells
Microfluidic assay
Sepsis
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-018-1342-y

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