Disordered Peptides Looking for Their Native Environment: Structural Basis of CB1 Endocannabinoid Receptor Binding to Pepcans

Disordered Peptides Looking for Their Native Environment: Structural Basis of CB1 Endocannabinoid Receptor Binding to Pepcans

Endocannabinoid peptides, or “pepcans,” are endogenous ligands of the CB1 cannabinoid receptor. Depending on their length, they display diverse activity: For instance, the nona-peptide Pepcan-9, also known as hemopressin, is a powerful inhibitor of CB1, whereas the longer variant Pepcan-12, which ex...

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Bibliografische gegevens
Hoofdauteurs: Alessandro Emendato, Remo Guerrini, Erika Marzola, Hans Wienk, Rolf Boelens, Serena Leone, Delia Picone
Formaat: Artikel
Taal:English
Gepubliceerd in: Frontiers Media S.A. 2018-11-01
Reeks:Frontiers in Molecular Biosciences
Onderwerpen:
pepcans
CB1 endocannabinoid receptor
endocannabinoid system
hemopressin
structure-activity relationships
intrinsically unfolded peptides
Online toegang:https://www.frontiersin.org/article/10.3389/fmolb.2018.00100/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2018.00100/full

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